scholarly journals Comparison of different microCT-based morphology assessment tools using human trabecular bone

Bone Reports ◽  
2020 ◽  
Vol 12 ◽  
pp. 100261
Author(s):  
Lukas Steiner ◽  
Alexander Synek ◽  
Dieter H. Pahr
Keyword(s):  
Trabecular Bone ◽  
Assessment Tools ◽  
Human Trabecular Bone

Age-related changes in resorption cavity characteristics in human trabecular bone

1991 ◽  
Vol 1 (4) ◽  
pp. 257-261 ◽  
Author(s):  
P. I. Croucher ◽  
N. J. Garrahan ◽  
R. W. E. Mellish ◽  
Juliette E. Compston
Keyword(s):  
Trabecular Bone ◽  
Human Trabecular Bone ◽  
Age Related ◽  
Cavity Characteristics ◽  
Age Related Changes

scholarly journals Biaxial Normal Strength Behavior in the Axial-Transverse Plane for Human Trabecular Bone—Effects of Bone Volume Fraction, Microarchitecture, and Anisotropy

2013 ◽  
Vol 135 (12) ◽  
Author(s):  
Arnav Sanyal ◽  
Tony M. Keaveny
Keyword(s):  
Trabecular Bone ◽  
Volume Fraction ◽  
Elastic Anisotropy ◽  
Bone Volume ◽  
Transverse Plane ◽  
Mechanical Anisotropy ◽  
Bone Volume Fraction ◽  
Human Trabecular Bone ◽  
Strength Behavior ◽  
Normal Strength

The biaxial failure behavior of the human trabecular bone, which has potential relevance both for fall and gait loading conditions, is not well understood, particularly for low-density bone, which can display considerable mechanical anisotropy. Addressing this issue, we investigated the biaxial normal strength behavior and the underlying failure mechanisms for human trabecular bone displaying a wide range of bone volume fraction (0.06–0.34) and elastic anisotropy. Micro-computed tomography (CT)-based nonlinear finite element analysis was used to simulate biaxial failure in 15 specimens (5 mm cubes), spanning the complete biaxial normal stress failure space in the axial-transverse plane. The specimens, treated as approximately transversely isotropic, were loaded in the principal material orientation. We found that the biaxial stress yield surface was well characterized by the superposition of two ellipses—one each for yield failure in the longitudinal and transverse loading directions—and the size, shape, and orientation of which depended on bone volume fraction and elastic anisotropy. However, when normalized by the uniaxial tensile and compressive strengths in the longitudinal and transverse directions, all of which depended on bone volume fraction, microarchitecture, and mechanical anisotropy, the resulting normalized biaxial strength behavior was well described by a single pair of (longitudinal and transverse) ellipses, with little interspecimen variation. Taken together, these results indicate that the role of bone volume fraction, microarchitecture, and mechanical anisotropy is mostly accounted for in determining the uniaxial strength behavior and the effect of these parameters on the axial-transverse biaxial normal strength behavior per se is minor.

scholarly journals Development of a Crushable Foam Model for Human Trabecular Bone

2021 ◽  
Author(s):  
Navid Soltanihafshejani ◽  
Thom Bitter ◽  
Dennis Janssen ◽  
Nico Verdonschot
Keyword(s):  
Trabecular Bone ◽  
Human Trabecular Bone ◽  
Foam Model

TEM analysis of the nanostructure of normal and osteoporotic human trabecular bone

Bone ◽  
2003 ◽  
Vol 33 (3) ◽  
pp. 270-282 ◽  
Author(s):  
Matthew A Rubin ◽  
Iwona Jasiuk ◽  
Jeannette Taylor ◽  
Janet Rubin ◽  
Timothy Ganey ◽  
...  
Keyword(s):  
Trabecular Bone ◽  
Tem Analysis ◽  
Human Trabecular Bone

Micromechanical properties of human trabecular bone: A hierarchical investigation using nanoindentation

2008 ◽  
Vol 87A (1) ◽  
pp. 196-202 ◽  
Author(s):  
Jonathan Norman ◽  
Joe G. Shapter ◽  
Ken Short ◽  
Lachlan J. Smith ◽  
Nicola L. Fazzalari
Keyword(s):  
Trabecular Bone ◽  
Human Trabecular Bone ◽  
Micromechanical Properties

Ex Vivo Human Trabecular Bone Model for Biocompatibility Evaluation of Calcium Phosphate Composites Modified with Spray Dried Biodegradable Microspheres

2013 ◽  
Vol 2 (10) ◽  
pp. 1361-1369 ◽  
Author(s):  
Julia Schnieders ◽  
Uwe Gbureck ◽  
Oliver Germershaus ◽  
Marita Kratz ◽  
David B. Jones ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Trabecular Bone ◽  
Ex Vivo ◽  
Biodegradable Microspheres ◽  
Bone Model ◽  
Human Trabecular Bone ◽  
Spray Dried

Inverse Finite Element Modeling for Characterization of Local Elastic Properties in Image-Guided Failure Assessment of Human Trabecular Bone

2015 ◽  
Vol 137 (1) ◽  
Author(s):  
Alexander Zwahlen ◽  
David Christen ◽  
Davide Ruffoni ◽  
Philipp Schneider ◽  
Werner Schmölz ◽  
...  
Keyword(s):  
Trabecular Bone ◽  
Bone Structure ◽  
Experimental Studies ◽  
Tissue Level ◽  
Heterogeneous Distribution ◽  
Human Trabecular Bone ◽  
Young’S Moduli ◽  
Failure Assessment ◽  
Experimental Strain

The local interpretation of microfinite element (μFE) simulations plays a pivotal role for studying bone structure–function relationships such as failure processes and bone remodeling. In the past μFE simulations have been successfully validated on the apparent level, however, at the tissue level validations are sparse and less promising. Furthermore, intratrabecular heterogeneity of the material properties has been shown by experimental studies. We proposed an inverse μFE algorithm that iteratively changes the tissue level Young’s moduli such that the μFE simulation matches the experimental strain measurements. The algorithm is setup as a feedback loop where the modulus is iteratively adapted until the simulated strain matches the experimental strain. The experimental strain of human trabecular bone specimens was calculated from time-lapsed images that were gained by combining mechanical testing and synchrotron radiation microcomputed tomography (SRμCT). The inverse μFE algorithm was able to iterate the heterogeneous distribution of moduli such that the resulting μFE simulations matched artificially generated and experimentally measured strains.

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