Increased brain penetration of diphenhydramine and memantine in rats with adjuvant-induced arthritis

2021 ◽  
pp. 147581
Author(s):  
Atsushi Kawase ◽  
Akira Kazaoka ◽  
Hiroaki Shimada ◽  
Masahiro Iwaki
Keyword(s):  
Brain Penetration ◽  
Adjuvant Induced Arthritis

Effect of methanolic extract of Barleria lupulina Lindl. in adjuvant induced arthritis in rats

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
P MitraMazumder ◽  
A Mondal ◽  
S Arulmozhi ◽  
D Sasmal
Keyword(s):  
Methanolic Extract ◽  
Adjuvant Induced Arthritis

Development of Solid Lipid Nanoparticles of Lamivudine for Brain Targeting

2009 ◽  
Vol 1 (1) ◽  
Author(s):  
Pravin Patil ◽  
Anil Sharma ◽  
Subhash Dadarwal ◽  
Vijay Sharma
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Solid Lipid Nanoparticles ◽  
Rotation Speed ◽  
Lipid Nanoparticles ◽  
Brain Targeting ◽  
Brain Penetration ◽  
Solid Lipid ◽  
Diffusion Technique

The objective of present investigation was to enhance brain penetration of Lamivudine, one of the most widely used drugs for the treatment of AIDS. This was achieved through incorporating the drug into solid lipid nanoparticles (SLN) prepared by using emulsion solvent diffusion technique. The formulations were characterized for surface morphology, size and size distribution, percent drug entrapment and drug release. The optimum rotation speed, resulting into better drug entrapment and percent yield, was in the range of 1000-1250 r/min. In vitro cumulative % drug release from optimized SLN formulation was found 40-50 % in PBS (pH-7.4) and SGF (pH-1.2) respectively for 10 h. After 24 h more than 65 % of the drug was released from all formulations in both mediums meeting the requirement for drug delivery for prolong period of time.

Brain penetration and neurological effects of gadobenate dimeglumine in the rat

1997 ◽  
Vol 38 (2) ◽  
pp. 268-272 ◽  
Author(s):  
F. Luzzani ◽  
P. Cipolla ◽  
M. L. Pelaprat ◽  
F. Robert ◽  
C. Gotti ◽  
...  
Keyword(s):  
Gadobenate Dimeglumine ◽  
Brain Penetration ◽  
Neurological Effects
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