Dose-response relationship between fat distribution and liver cancer incidence: A prospective cohort study in Chinese men

2022 ◽  
Vol 76 ◽  
pp. 102091
Author(s):  
Zhuo-Ying Li ◽  
Yu-Ting Tan ◽  
Jing Wang ◽  
Jie Fang ◽  
Da-Ke Liu ◽  
...  
2021 ◽  
Vol 148 (12) ◽  
pp. 2982-2996
Author(s):  
Xiao‐Wei Ji ◽  
Jing Wang ◽  
Qiu‐Ming Shen ◽  
Zhuo‐Ying Li ◽  
Yu‐Fei Jiang ◽  
...  

2020 ◽  
Author(s):  
Yu Lv ◽  
Qian Xiang ◽  
Jia Lin ◽  
Ying Zong Jin ◽  
Ying Fang ◽  
...  

Abstract BackgroundThe association between allogeneic blood transfusion (ABT) and healthcare-associated infection (HAI) is considered dose-dependent. However, this association may be confounded by transfusion duration, as prolonged hospitalization stay increases the risk of HAI. Also, it is not clear whether specific blood products have different dose-response risks.MethodsIn this retrospective cohort study, a logistic regression was used to identify confounding factors, and the association between specific blood products and HAI were analyzed. Then Cox regression and restricted cubic spline regression was used to visualize the hazard of HAI per transfusion product.ResultsOf 215338 inpatients observed, 4.16% were transfused with a single component blood product. With regard to these transfused patients, 480 patients (5.36 %) developed a HAI during their hospitalization stay. Logistic regression showed that red blood cells (RBCs) transfusion, platelets transfusion and fresh-frozen plasmas (FFPs) transfusion were risk factors for HAI [odds ratio (OR) 1.893, 95% confidence interval (CI) 1.656–2.163; OR 8.903, 95% CI 6.646–11.926 and OR 1.494, 95% CI 1.146–1.949, respectively]. However, restricted cubic spline regression analysis showed that there was no statistically dose-response relationship between different transfusion products and the onset of HAI.ConclusionsRBCs transfusion, platelets transfusion and FFPs transfusion were associated with HAI, but there was no dose-response relationship between them.


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