Exosomes laden self-healing injectable hydrogel enhances diabetic wound healing via regulating macrophage polarization to accelerate angiogenesis

2022 ◽  
Vol 430 ◽  
pp. 132664
Author(s):  
Kai Wang ◽  
Ruonan Dong ◽  
Jiezhang Tang ◽  
Huichen Li ◽  
Juanli Dang ◽  
...  
Theranostics ◽  
2021 ◽  
Vol 11 (20) ◽  
pp. 10174-10175
Author(s):  
Chenggui Wang ◽  
Min Wang ◽  
Tianzhen Xu ◽  
Xingxing Zhang ◽  
Cai Lin ◽  
...  

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Fanxing Xu ◽  
Chenying Zhang ◽  
Dana T. Graves

Impaired diabetic wound healing constitutes a major health problem. The impaired healing is caused by complex factors such as abnormal keratinocyte and fibroblast migration, proliferation, differentiation, and apoptosis, abnormal macrophage polarization, impaired recruitment of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), and decreased vascularization. Diabetes-enhanced and prolonged expression of TNF-αalso contributes to impaired healing. In this paper, we discuss the abnormal cell responses in diabetic wound healing and the contribution of TNF-α.


2020 ◽  
Vol 140 (8) ◽  
pp. 1629-1638 ◽  
Author(s):  
Junyi Hu ◽  
Liping Zhang ◽  
Cole Liechty ◽  
Carlos Zgheib ◽  
Maggie M. Hodges ◽  
...  

2020 ◽  
Vol 133 (19) ◽  
pp. jcs235838
Author(s):  
Peilang Yang ◽  
Xiqiao Wang ◽  
Di Wang ◽  
Yan Shi ◽  
Meng Zhang ◽  
...  

ABSTRACTBesides regulating glucose levels, insulin has been reported to participate actively in many other functions, including modulating inflammatory reactions. In this study we investigated how topical insulin application would affect the diabetic wound healing process. We found that the excessive expression of insulin-degrading enzyme led to insufficient insulin levels in diabetic skin during wound healing, which ultimately reduced the recovery rate of diabetic wounds. We confirmed that topical insulin application could reverse the impaired inflammation reaction in the diabetic wound environment and promote healing of diabetic wounds. Our study revealed that insulin promoted apoptosis of neutrophils and subsequently triggered polarization of macrophages. Both in vivo and in vitro studies verified that insulin re-established phagocytosis function and promoted the process of phagocytosis-induced apoptosis in neutrophils. Furthermore, we found that insulin treatment also promoted efferocytosis of the apoptosed neutrophils by macrophages, and thus induced macrophages to change their polarization state from M1 to M2. In conclusion, our studies proved that the exogenous application of insulin could improve diabetic wound healing via the restoration of the inflammatory response.


2020 ◽  
Vol 12 (50) ◽  
pp. 55659-55674
Author(s):  
Zhiyong Qian ◽  
Haiping Wang ◽  
Yating Bai ◽  
Yuqing Wang ◽  
Lei Tao ◽  
...  

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