scholarly journals INFREQUENT EXTRA-NODAL MANIFESTATION OF A NON-HODGKIN'S LYMPHOMA

CHEST Journal ◽  
2021 ◽  
Vol 160 (4) ◽  
pp. A767
Author(s):  
Valeria Trelles Garcia ◽  
Agata Parfieniuk ◽  
Daniela Trelles Garcia ◽  
Hung-I Liao
1993 ◽  
Vol 70 (04) ◽  
pp. 568-572 ◽  
Author(s):  
Roberto Stasi ◽  
Elisa Stipa ◽  
Mario Masi ◽  
Felicia Oliva ◽  
Alessandro Sciarra ◽  
...  

SummaryThis study was designed to explore the prevalence and clinical significance of elevated antiphospholipid antibodies (APA) titres in patients affected by acute myeloid leukemia (AML) and highgrade non-Hodgkin’s lymphoma (NHL). We also analyzed possible correlations with circulating levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and the soluble form of the receptor for interleukin-2 (sIL-2r). Nineteen patients with de novo AML and 14 patients with newly-diagnosed NHL were investigated. Tests for APA included the measurement of anticardiolipin antibodies (ACA) with a solid-phase immunoassay, and the detection of the lupus-like anticoagulant (LA) activity. Five patients with AML (26.3%) and 5 patients with NHL (35.7%) presented elevated APA at diagnosis, as compared to 3 of 174 persons of the control group (p <0.0001). APA titres became normal in all patients responding to treatment, whereas nonresponders retained elevated levels. In addition, 6 patients (4 with AML and 2 with NHL), who had normal APA at diagnosis and were either refractory to treatment or in relapse, subsequently developed LA and/or ACA positivity. At presentation, the mean levels of IgG- and IgM-ACA in patients were not significantly different from Controls, and concordance between ACA and LA results reached just 30%. With regard to the clinical course, we were not able to detect any statistically significant difference between patients with normal and elevated APA. Pretreatment concentrations of IL-6 and TNF-alpha in AML, and sIL-2r in NHL were found significantly elevated compared to Controls (p = 0.003, p = 0.009 and p = 0.024 respectively). In addition, the levels of these cytokines correlated with IgG-ACA at the different times of laboratory investigations. These results demonstrate that APA may have a role as markers of disease activity and progression in some haematological malignancies.


2014 ◽  
Vol 1 (2) ◽  
pp. 18-20
Author(s):  
Mohammad Chisti ◽  
◽  
Alaa Muslimani ◽  
Hamed Daw ◽  
Ishmael Jaiyesimi ◽  
...  

1997 ◽  
Vol 38 (2) ◽  
pp. 259-267 ◽  
Author(s):  
H. Lanfermann ◽  
W. Heindel ◽  
J. Schaper ◽  
R. Schroder ◽  
M. -L. Hansmann ◽  
...  

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