scholarly journals The wound healing potential of collagen peptides derived from the jellyfish Rhopilema esculentum

2019 ◽  
Vol 22 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Fatuma Felix Felician ◽  
Rui-He Yu ◽  
Meng-Zhen Li ◽  
Chun-Jie Li ◽  
Hui-Qin Chen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Rhopilema Esculentum ◽  
Collagen Peptides

scholarly journals Marine fish peptides (collagen peptides) compound intake promotes wound healing in rats after cesarean section

2020 ◽  
Vol 64 (0) ◽  
Author(s):  
Xue Peng ◽  
Jinfeng Xu ◽  
Yuan Tian ◽  
Wenjun Liu ◽  
Bing Peng
Keyword(s):  
Wound Healing ◽  
Cesarean Section ◽  
Marine Fish ◽  
Collagen Peptides

scholarly journals Sponges of Carboxymethyl Chitosan Grafted with Collagen Peptides for Wound Healing

2019 ◽  
Vol 20 (16) ◽  
pp. 3890 ◽  
Author(s):  
Yu Cheng ◽  
Zhang Hu ◽  
Yuntao Zhao ◽  
Zuhao Zou ◽  
Sitong Lu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Ftir Spectroscopy ◽  
Complete Healing ◽  
Carboxymethyl Chitosan ◽  
Pathological Examination ◽  
In Vitro Tests ◽  
Burn Care ◽  
Collagen Peptides ◽  
Fiber Deposition

Burns are physically debilitating and potentially fatal injuries. Two marine biomaterials, carboxymethyl chitosan (CMC) and collagen peptides (COP), have emerged as promising burn dressings. In this paper, sponges of carboxymethyl chitosan grafted with collagen peptide (CMC–COP) were prepared by covalent coupling and freeze drying. Scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy were then used to characterize the prepared sponges. To evaluate the wound healing activity of the CMC–COP sponges, in vitro tests including cell viability scratch wound healing and scald wound healing experiments were performed in rabbits. Appearance studies revealed the porous nature of sponges and FTIR spectroscopy demonstrated the successful incorporation of COP into CMC. The in vitro scratch assay showed that treatment with CMC–COP sponges (at 100 μg/mL) had significant effects on scratch closure. For burn wounds treated with CMC–COP, regeneration of the epidermis and collagen fiber deposition was observed on day 7, with complete healing of the epidermis and wound on days 14 and 21, respectively. Based on the pathological examination by hematoxylin and eosinstaining, the CMC–COP group demonstrated pronounced wound healing efficiencies. These results confirmed that the CMC–COP treatment enhanced cell migration and promoted skin regeneration, thereby highlighting the potential application of these sponges in burn care.

scholarly journals Potentiating cutaneous wound healing in young and aged skin with nutraceutical collagen peptides

2020 ◽  
Vol 46 (1) ◽  
pp. 109-117
Author(s):  
K. Mistry ◽  
B. Steen ◽  
T. Clifford ◽  
F. Holthoon ◽  
A. Kleinnijenhuis ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Collagen Peptides ◽  
Aged Skin

scholarly journals Collagen Peptides Derived from Sipunculus nudus Accelerate Wound Healing

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1385
Author(s):  
Haisheng Lin ◽  
Zhihong Zheng ◽  
Jianjun Yuan ◽  
Chaohua Zhang ◽  
Wenhong Cao ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Repair ◽  
Transforming Growth Factor ◽  
Umbilical Vein ◽  
Smooth Muscle Actin ◽  
Mrna Level ◽  
Skin Wound ◽  
Control Group ◽  
Collagen Peptides ◽  
Sipunculus Nudus

Marine collagen peptides have high potential in promoting skin wound healing. This study aimed to investigate wound healing activity of collagen peptides derived from Sipunculus nudus (SNCP). The effects of SNCP on promoting healing were studied through a whole cortex wound model in mice. Results showed that SNCP consisted of peptides with a molecular weight less than 5 kDa accounted for 81.95%, rich in Gly and Arg. SNCP possessed outstanding capacity to induce human umbilical vein endothelial cells (HUVEC), human immortalized keratinocytes (HaCaT) and human skin fibroblasts (HSF) cells proliferation and migration in vitro. In vivo, SNCP could markedly improve the healing rate and shorten the scab removal time, possessing a scar-free healing effect. Compared with the negative control group, the expression level of tumor necrosis factor-α, interleukin-1β and transforming growth factor-β1 (TGF-β1) in the SNCP group was significantly down-regulated at 7 days post-wounding (p < 0.01). Moreover, the mRNA level of mothers against decapentaplegic homolog 7 (Smad7) in SNCP group was up-regulated (p < 0.01); in contrast, type II TGF-β receptors, collagen I and α-smooth muscle actin were significantly down-regulated at 28 days (p < 0.01). These results indicate that SNCP possessed excellent activity of accelerating wound healing and inhibiting scar formation, and its mechanism was closely related to reducing inflammation, improving collagen deposition and recombination and blockade of the TGF-β/Smads signal pathway. Therefore, SNCP may have promising clinical applications in skin wound repair and scar inhibition.

scholarly journals 791 Promoting cutaneous wound healing with nutraceutical porcine type I collagen peptides

2020 ◽  
Vol 140 (7) ◽  
pp. S104
Author(s):  
K. Mistry ◽  
B. Van Der Steen ◽  
B. Vanhoecke ◽  
F. van Holthoon ◽  
A. Kleinnijenhuis ◽  
...  
Keyword(s):  
Wound Healing ◽  
Type I Collagen ◽  
Type I ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Collagen Peptides
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