Impact of high-intensity interval training combined with intermittent fasting on short-chain fatty acids in obese women

2021 ◽  
Vol 46 ◽  
pp. S581-S582
Author(s):  
G. Batitucci ◽  
O.G.G. Almeida ◽  
I. Solar ◽  
E.C.P. De Martinis ◽  
D.E. Cintra ◽  
...  
2017 ◽  
Vol 124 (2) ◽  
pp. 149-155 ◽  
Author(s):  
Selma Arzu Vardar ◽  
Aziz Karaca ◽  
Sibel Güldiken ◽  
Orkide Palabıyık ◽  
Necdet Süt ◽  
...  

2021 ◽  
Vol 9 (A) ◽  
pp. 871-875
Author(s):  
Susiana Candrawati ◽  
Emy Huriyati ◽  
Zaenal Muttaqien Sofro ◽  
Lantip Rujito ◽  
Aulia Nury Faza ◽  
...  

Background: Increased inflammatory mediators in obesity are associated with metabolic syndrome. Exercise is an effective effort to reduce the incidence of obesity. The High-Intensity Interval Training (HIIT) program is an exercise which include combination of high-intensity exercise and rest periods. The decrease in body fat levels due to physical training will further affect inflammatory mediators such as IL6 and TNFα. Besides training factor, genetic also play a role on obesity. One of the genes that influence obesity is the UCP2 Ala55Val gene. Objectives: This research aims to see the effect of HIIT on the levels of inflammatory mediators in obese patients based on the study of the Ala55Val UCP2 gene. Methods: This study was a Quasi-Experimental Pre and Post Design Without Control Group. Thirty obese women (BMI≥25 kg/m2) were given High-Intensity Interval Training (HIIT) as an intervention by comparing the data before and after the intervention. The training intervention was conducted for 12 weeks, consisting of two weeks of adaptation and ten weeks of HIIT intervention. The body weight, BMI and inflammatory mediators (TNFα and IL 6) before and after the intervention were analyzed using the Dependent T-Test and Wilcoxon Test as a nonparametric test. Independent T-Test and Mann Whitney test used to determine the effect of the UCP2 Ala55Val gene on changes in body weight, BMI and the inflammatory mediator. The test results were considered significantly different if p<0.05. Results: Bivariate analysis using Dependent T-Test showed that HIIT significantly improved Body Weight, BMI and IL6 with p=0.0001. Wilcoxon Test showed that HIIT significantly improved TNFα with p=0.0001. Independent T-Test showed no difference in body weight (p=0.719), BMI (p=0.663) and TNFα (p=0.264) improvement in the two genotypes of the UCP2 Ala55Val gene. Mann Whitney Test showed no difference in IL6 (p=0.288) improvement in the two genotypes of the UCP2 Ala55Val gene. Conclusion: The research concluded that the 12-week HIIT interventions improved inflammatory mediators by reducing IL6 and TNFα in obese women. There was no effect of genetic variation on the response to training intervention.


Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1764 ◽  
Author(s):  
Robin A. Wilson ◽  
Christos G. Stathis ◽  
Alan Hayes ◽  
Matthew B. Cooke

The molecular adaptations that underpin body composition changes and health benefits of intermittent fasting (IF) and high-intensity interval training (HIIT) are unclear. The present study investigated these adaptations within the hypothalamus, white adipose and skeletal muscle tissue following 12 weeks of IF and/or HIIT in diet-induced obese mice. Mice (C57BL/6, 8-week-old, males/females) were fed high-fat (59%) and sugar (30%) water (HF/S) for 12 weeks followed by an additional 12 weeks of HF/S plus either IF, HIIT, combination (IF+HIIT) or HF/S only control (CON). Tissues were harvested at 12 and 24 weeks and analysed for various molecular markers. Hypothalamic NPY expression was significantly lower following IF+HIIT compared to CON in females. In adipose tissue, leptin expression was significantly lower following IF and IF+HIIT compared to CON in males and females. Males demonstrated increased markers of fat oxidation (HADH, FABP4) following IF+HIIT, whereas females demonstrated reduced markers of adipocyte differentiation/storage (CIDEC and FOXO1) following IF and/or IF+HIIT. In muscle, SIRT1, UCP3, PGC1α, and AS160 expression was significantly lower following IF compared to CON in males and/or females. This investigation suggests that males and females undertaking IF and HIIT may prevent weight gain via different mechanisms within the same tissue.


2018 ◽  
Vol 19 (4) ◽  
pp. 356-366 ◽  
Author(s):  
Alba Camacho-Cardenosa ◽  
Marta Camacho-Cardenosa ◽  
Javier Brazo-Sayavera ◽  
Martin Burtscher ◽  
Rafael Timón ◽  
...  

2019 ◽  
Vol 51 (Supplement) ◽  
pp. 448-449
Author(s):  
Ozgur Alan ◽  
Emily W. Flanagan ◽  
Lafayette T. Watson ◽  
Andrew N.L. Buskard ◽  
Demet Tekin ◽  
...  

2015 ◽  
Vol 34 (3) ◽  
pp. 501-507 ◽  
Author(s):  
Nuria Salazar ◽  
Evelyne M. Dewulf ◽  
Audrey M. Neyrinck ◽  
Laure B. Bindels ◽  
Patrice D. Cani ◽  
...  

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