Current applications of high-intensity ultrasound with microbial inactivation or stimulation purposes in dairy products

Author(s):  
Jonas T Guimarães ◽  
Hugo Scudino ◽  
Gustavo LPA Ramos ◽  
Gabriella AR Oliveira ◽  
Larissa P Margalho ◽  
...  
2018 ◽  
Vol 44 ◽  
pp. 251-260 ◽  
Author(s):  
Jonas T. Guimarães ◽  
Eric Keven Silva ◽  
Verônica O. Alvarenga ◽  
Ana Letícia R. Costa ◽  
Rosiane L. Cunha ◽  
...  

2019 ◽  
Vol 57 ◽  
pp. 12-21 ◽  
Author(s):  
Jonas T. Guimarães ◽  
Celso F. Balthazar ◽  
Hugo Scudino ◽  
Tatiana C. Pimentel ◽  
Erick A. Esmerino ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jeong Yu Lee ◽  
Dae-Jin Min ◽  
Wanil Kim ◽  
Bum-Ho Bin ◽  
Kyuhan Kim ◽  
...  

AbstractInspired by the effectiveness of low-intensity ultrasound on tissue regeneration, we investigated the potential effect of short-term high-intensity ultrasound treatment for acceleration of wound healing in an in vitro wound model and dermal equivalent, both comprising human dermal fibroblasts. Short-term ultrasound of various amplitudes significantly increased the proliferation and migration of fibroblasts and subsequently increased the production of the extracellular matrix components fibronectin and collagen type I, both of which are important for wound healing and are secreted by fibroblasts. In addition, ultrasound treatment increased the contraction of a fibroblast-embedded three-dimensional collagen matrix, and the effect was synergistically increased in the presence of TGF-β. RNA-sequencing and bioinformatics analyses revealed changes in gene expression and p38 and ERK1/2 MAPK pathway activation in the ultrasound-stimulated fibroblasts. Our findings suggest that ultrasound as a mechanical stimulus can activate human dermal fibroblasts. Therefore, the activation of fibroblasts using ultrasound may improve the healing of various types of wounds and increase skin regeneration.


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