Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance

2007 ◽  
Vol 7 (4) ◽  
pp. 367-374 ◽  
Author(s):  
Hui-Wen Lo ◽  
Francis Ali-Osman
Keyword(s):  
Drug Resistance ◽  
Genetic Polymorphism ◽  
Tumor Drug Resistance ◽  
Glutathione S Transferases ◽  
And Function

scholarly journals Mechanistic Modeling Identifies Drug-Uptake History as Predictor of Tumor Drug Resistance and Nano-Carrier-Mediated Response

ACS Nano ◽  
2013 ◽  
Vol 7 (12) ◽  
pp. 11174-11182 ◽  
Author(s):  
Jennifer Pascal ◽  
Carlee E. Ashley ◽  
Zhihui Wang ◽  
Terisse A. Brocato ◽  
Joseph D. Butner ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Mechanistic Modeling ◽  
Drug Uptake ◽  
Tumor Drug Resistance

scholarly journals HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

2018 ◽  
Vol 47 (3) ◽  
pp. 893-913 ◽  
Author(s):  
Qing Tang ◽  
Swei Sunny Hann
Keyword(s):  
Drug Resistance ◽  
Human Cancer ◽  
Critical Role ◽  
Stem Cell Differentiation ◽  
Human Diseases ◽  
Biological Functions ◽  
Protein Coding ◽  
Non Coding Rna ◽  
And Function ◽  
Long Non Coding Rna

Long non-coding RNAs (LncRNAs) represent a novel class of noncoding RNAs that are longer than 200 nucleotides without protein-coding potential and function as novel master regulators in various human diseases, including cancer. Accumulating evidence shows that lncRNAs are dysregulated and implicated in various aspects of cellular homeostasis, such as proliferation, apoptosis, mobility, invasion, metastasis, chromatin remodeling, gene transcription, and post-transcriptional processing. However, the mechanisms by which lncRNAs regulate various biological functions in human diseases have yet to be determined. HOX antisense intergenic RNA (HOTAIR) is a recently discovered lncRNA and plays a critical role in various areas of cancer, such as proliferation, survival, migration, drug resistance, and genomic stability. In this review, we briefly introduce the concept, identification, and biological functions of HOTAIR. We then describe the involvement of HOTAIR that has been associated with tumorigenesis, growth, invasion, cancer stem cell differentiation, metastasis, and drug resistance in cancer. We also discuss emerging insights into the role of HOTAIR as potential biomarkers and therapeutic targets for novel treatment paradigms in cancer.

scholarly journals Artificial microenvironment of in vitro glioblastoma cell cultures changes profile of miRNAs related to tumor drug resistance

2019 ◽  
Vol Volume 12 ◽  
pp. 3905-3918
Author(s):  
Monika Witusik-Perkowska ◽  
Magdalena Zakrzewska ◽  
Dariusz Jaskolski ◽  
Paweł P Liberski ◽  
Janusz Szemraj
Keyword(s):  
Drug Resistance ◽  
Cell Cultures ◽  
Glioblastoma Cell ◽  
Tumor Drug Resistance

Biotinylated carboxymethyl chitosan/CaCO3 hybrid nanoparticles for targeted drug delivery to overcome tumor drug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (73) ◽  
pp. 69083-69093 ◽  
Author(s):  
Jin-Long Wu ◽  
Xiao-Yan He ◽  
Pei-Yuan Jiang ◽  
Meng-Qing Gong ◽  
Ren-Xi Zhuo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Tumor Cells ◽  
Targeted Drug Delivery ◽  
Carboxymethyl Chitosan ◽  
Hybrid Nanoparticles ◽  
Cancer Drug ◽  
Tumor Drug Resistance ◽  
Anti Cancer ◽  
Targeted Drug

A tumor targeted nano-sized self-assembled drug delivery system could efficiently co-deliver an anti-cancer drug and a drug resistance inhibitor to tumor cells and achieve an improved therapeutic efficiency through inhibition of P-gp function.

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