Expanded polyvinyl alcohol is regarded as excellent buffering and leak-proof packaging material of liquid products due to its characteristics such as good liquid absorption and liquid retention properties, good mechanical properties under dry condition, and good rebound resilience under wet condition. Through static compression experiment, this study analyzed the mechanical properties and energy absorption properties of expanded polyvinyl alcohol with different densities under different temperatures and relative humidity. The experimental results showed that the effect of ambient temperature and humidity on expanded polyvinyl alcohol performance was mainly to change its internal moisture. The initial elastic modulus, plateau stress, and energy absorption value per unit volume of expanded polyvinyl alcohol increased as the density increased, the relative humidity decreased, or temperature increased. The above research can provide reference for applications of expanded polyvinyl alcohol on buffering packaging in actual logistic environment.