scholarly journals The diagnostic value of cytokines for the discrimination of vertebral osteomyelitis and degenerative diseases of the spine

Cytokine ◽  
2022 ◽  
Vol 150 ◽  
pp. 155782
Author(s):  
Julia Brinkmann ◽  
Eva-Carina Zeißler ◽  
Jan Simon Scharrenberg ◽  
Julia Schenk ◽  
Mohamed Majjouti ◽  
...  
2017 ◽  
Vol 45 (5) ◽  
pp. 798-805 ◽  
Author(s):  
Ilse J. E. Kouijzer ◽  
Henk Scheper ◽  
Jacky W. J. de Rooy ◽  
Johan L. Bloem ◽  
Marcel J. R. Janssen ◽  
...  

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Jan Simon Scharrenberg ◽  
Ayla Yagdiran ◽  
Julia Brinkmann ◽  
Maik Brune ◽  
Jan Siewe ◽  
...  

Abstract Background There is still a challenge in discriminating between vertebral osteomyelitis and degenerative diseases of the spine. To this end, we determined the suitability of soluble urokinase-type plasminogen activator receptor (suPAR) and compared the diagnostic potential of suPAR to CRP. Methods Patients underwent surgical stabilization of the lumbar and/or thoracic spine with removal of one or more affected intervertebral discs, as therapy for vertebral osteomyelitis (n = 16) or for erosive osteochondrosis (control group, n = 20). In this prospective study, we evaluated the suPAR and CRP levels before (pre-OP) and after surgery (post-OP) on days 3–5, 6–11, 40–56, and 63–142. Results The suPAR levels in vertebral osteomyelitis patients were significantly higher than those from controls pre-OP, 3–5 days post-OP, and 6–11 days post-OP. Significantly higher CRP levels were observed in the vertebral osteomyelitis group than in the controls pre-OP and 6–11 days post-OP. Levels of suPAR and CRP correlated positively in all patients in the pre-OP period: r = 0.63 (95% CI: 0.37–0.79), p < 0.0001. The values for the area under the receiver operating characteristics curve (AUC) for pre-OP and the overall model post-OP were 0.88 (95% CI: 0.76–1.00) and 0.84 (95% CI: 0.71–0.97) for suPAR, 0.93 (95% CI: 0.85–1.00) and 0.77 (95% CI: 0.62–0.93) for CRP, and 0.98 (95% CI: 0.96–1.00) and 0.91 (95% CI: 0.82–1.00) for the combination of suPAR and CRP. The AUC for suPAR pre-OP revealed an optimum cut-off value, sensitivity, specificity, NPV, and PPV of 2.96 ng/mL, 0.69, 1.00, 0.80, and 1.00, respectively. For CRP, these values were 11.58 mg/L, 0.88, 0.90, 0.90, and 0.88, respectively. Conclusion The present results show that CRP is more sensitive than suPAR whereas suPAR is more specific than CRP. Moreso, our study demonstrated that improvement in the diagnostic power for discrimination of vertebral osteomyelitis and degenerative diseases of the spine can be achieved by a combination of both suPAR and CRP. Trial registration ClinicalTrials.gov, NCT02554227, posted Sept. 18, 2015, and updated Aug. 13, 2019


Author(s):  
Gerald Fine ◽  
Azorides R. Morales

For years the separation of carcinoma and sarcoma and the subclassification of sarcomas has been based on the appearance of the tumor cells and their microscopic growth pattern and information derived from certain histochemical and special stains. Although this method of study has produced good agreement among pathologists in the separation of carcinoma from sarcoma, it has given less uniform results in the subclassification of sarcomas. There remain examples of neoplasms of different histogenesis, the classification of which is questionable because of similar cytologic and growth patterns at the light microscopic level; i.e. amelanotic melanoma versus carcinoma and occasionally sarcoma, sarcomas with an epithelial pattern of growth simulating carcinoma, histologically similar mesenchymal tumors of different histogenesis (histiocytoma versus rhabdomyosarcoma, lytic osteogenic sarcoma versus rhabdomyosarcoma), and myxomatous mesenchymal tumors of diverse histogenesis (myxoid rhabdo and liposarcomas, cardiac myxoma, myxoid neurofibroma, etc.)


1957 ◽  
Vol 33 (2) ◽  
pp. 163-171 ◽  
Author(s):  
Perry J. Culver ◽  
William V. McDermott ◽  
Chester M. Jones

1965 ◽  
Vol 48 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Howard E. Ticktin ◽  
Nelson P. Trujillo ◽  
Phyllis F. Evans ◽  
Joseph H. Roe

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