The role of a whole blood interferon-γ assay for the detection of latent tuberculosis infection in Bacille Calmette–Guérin vaccinated children

2008 ◽  
Vol 62 (4) ◽  
pp. 389-394 ◽  
Author(s):  
Jin-Kyong Chun ◽  
Chang Ki Kim ◽  
Hyon-Suk Kim ◽  
Ghee Young Jung ◽  
Taek Jin Lee ◽  
...  
Keyword(s):  
Whole Blood ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Interferon Γ ◽  
Tuberculosis Infection ◽  
Bacille Calmette Guerin

Latent tuberculosis infection in a military setting diagnosed by whole-blood interferon-γ assay

Respirology ◽  
2007 ◽  
Vol 12 (6) ◽  
pp. 898-901 ◽  
Author(s):  
Chang-Min CHOI ◽  
Seung Sik HWANG ◽  
Chang-Hoon LEE ◽  
Hye Won LEE ◽  
Cheol-In KANG ◽  
...  
Keyword(s):  
Whole Blood ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Interferon Γ ◽  
Tuberculosis Infection

scholarly journals Comparison of a whole blood Interferon-γ assay and A tuberculin skin test for detecting latent tuberculosis infection in children

2008 ◽  
Vol 51 (9) ◽  
pp. 971 ◽  
Author(s):  
Jin-Kyong Chun ◽  
Chang Ki Kim ◽  
Hyun Sook Kim ◽  
Ghee Young Jung ◽  
John A. Linton ◽  
...  
Keyword(s):  
Tuberculin Skin Test ◽  
Skin Test ◽  
Whole Blood ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Interferon Γ ◽  
Tuberculosis Infection

Role Of The QFT-IT Assay For The Diagnosis Of Latent Tuberculosis Infection Among Adult Immigrants

2011 ◽  
Author(s):  
Monica Losi ◽  
Paola Dal Monte ◽  
Roberto Cagarelli ◽  
Marisa Meacci ◽  
Cinzia Del Giovane ◽  
...  
Keyword(s):  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Adult Immigrants

scholarly journals Elevated Rates of Indeterminate Results on QuantiFERON®-TB Gold Plus in COVID-19 Patients

2021 ◽  
Author(s):  
Kileen L. Shier
Keyword(s):  
Critically Ill ◽  
Interferon Gamma ◽  
Clinical Microbiology ◽  
Latent Tuberculosis Infection ◽  
Immunosuppressive Agents ◽  
Latent Tuberculosis ◽  
Interferon Γ ◽  
Cytokine Expression ◽  
Tuberculosis Infection ◽  
Interferon Gamma Release Assays

Interferon-gamma release assays are used to screen various patient populations for latent tuberculosis infection. In this issue of the Journal of Clinical Microbiology, Ward et al. (J Clin Microbiol 59:e00811-21, 2021, https://doi.org/10.1128/JCM.00811-21 ) investigated an increased indeterminate rate in the QuantiFERON-TB Gold Plus assay among COVID-19 patients that was independent of immunosuppressive agents and lymphopenia. In their study, COVID-19 patients with indeterminate QuantiFERON-TB Gold Plus results trended toward decreased survival as well as increased serum IL-6 and IL-10 levels, though the differences were not statistically significant. They suggest that this pattern of cytokine expression supports an impairment of Th1, and specifically interferon-γ production, in critically ill COVID-19 patients, as indicated by indeterminate QuantiFERON-TB Gold Plus results. Clinicians should be aware of the increased rate of indeterminate QuantiFERON-TB Gold Plus results in critically ill COVID-19 patients.

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