A series of simple detection systems for genetic variants of flavin-containing monooxygenase 3 (FMO3) with impaired function in Japanese subjects

2021 ◽  
Vol 41 ◽  
pp. 100420
Author(s):  
Makiko Shimizu ◽  
Ami Mizugaki ◽  
Natsumi Koibuchi ◽  
Haruna Sango ◽  
Yumi Uenuma ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Detection Systems ◽  
Impaired Function ◽  
Simple Detection ◽  
Japanese Subjects

Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources

2021 ◽  
Vol 38 ◽  
pp. 100387
Author(s):  
Makiko Shimizu ◽  
Natsumi Koibuchi ◽  
Ami Mizugaki ◽  
Eiji Hishinuma ◽  
Sakae Saito ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Japanese Subjects

Minor genetic variants of the dopamine D4 receptor (DRD4) polymorphism are associated with novelty seeking in healthy Japanese subjects

2009 ◽  
Vol 33 (7) ◽  
pp. 1232-1235 ◽  
Author(s):  
Shoko Tsuchimine ◽  
Norio Yasui-Furukori ◽  
Ayako Kaneda ◽  
Manabu Saito ◽  
Norio Sugawara ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Novelty Seeking ◽  
Dopamine D4 Receptor ◽  
D4 Receptor ◽  
Japanese Subjects

scholarly journals Identification of three genetic variants as novel susceptibility loci for body mass index in a Japanese population

2018 ◽  
Vol 50 (3) ◽  
pp. 179-189 ◽  
Author(s):  
Yoshiki Yasukochi ◽  
Jun Sakuma ◽  
Ichiro Takeuchi ◽  
Kimihiko Kato ◽  
Mitsutoshi Oguri ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Genetic Variants ◽  
Japanese Population ◽  
Association Studies ◽  
Genome Wide Association Studies ◽  
Nucleotide Polymorphisms ◽  
Susceptibility Loci ◽  
Cross Sectional ◽  
Japanese Subjects

Recent genome-wide association studies have identified various obesity or metabolic syndrome (MetS) susceptibility loci. However, most studies were conducted in a cross-sectional manner. To address this gap, we performed a longitudinal exome-wide association study to identify susceptibility loci for obesity and MetS in a Japanese population. We traced clinical data of 6,022 Japanese subjects who had annual health check-ups for several years (mean follow-up period, 5 yr) and genotyped ~244,000 genetic variants. The association of single nucleotide polymorphisms (SNPs) with body mass index (BMI) or the prevalence of obesity and MetS was examined in a generalized estimating equation model. Our longitudinal exome-wide association studies detected 21 BMI- and five MetS-associated SNPs (false discovery rate, FDR <0.01). Among these SNPs, 16 have not been previously implicated as determinants of BMI or MetS. Cross-sectional data for obesity- and MetS-related phenotypes in 7,285 Japanese subjects were examined in a replication study. Among the 16 SNPs, three ( rs9491140 , rs145848316 , and rs7863248 ) were related to BMI in the replication cohort ( P < 0.05). In conclusion, three SNPs [ rs9491140 of NKAIN2 (FDR = 0.003, P = 1.9 × 10−5), rs145848316 of KMT2C (FDR = 0.007, P = 4.5 × 10−5), and rs7863248 of AGTPBP1 (FDR = 0.006, P = 4.2 × 10−5)] were newly identified as susceptibility loci for BMI.

Keeping Track with Things

2018 ◽  
Author(s):  
Richard Menary
Keyword(s):  
Contextual Learning ◽  
Learning Tools ◽  
Tracking Systems ◽  
Symbol Systems ◽  
Evolutionary Account ◽  
Detection Systems ◽  
Important Mediator ◽  
Simple Detection ◽  
Conventional Symbol

The chapter begins with an evolutionary account of tracking systems, from simple detection systems to complex decoupled and highly flexible tracking systems. The important mediator is the role of the environment in providing the complexity, translucency, and hostility that produces the evolutionary pressures that result in more complex tracking systems. An evolutionary platform is provided for how modern humans could have come to innovate epistemic tracking tools (ETTs) for keeping track of salient features of the environment. Three examples of ETTs in action are given, ranging from highly iconic and contextual learning tools—such as the Mattang—to highly abstract and decoupled conventional symbol systems. Finally, it is argued that ETTs are compatible with a responsibilist-reliabilism since their correct deployment requires epistemic diligence and the reliable functioning of the tool itself. As such, a framework for understanding and exploring how we keep track with things has been given.

scholarly journals Detection Papers with Metal Complexes with Triphenylmethane Dyes for the Detection of G-Series Nerve Agents (Sarin, Soman, Cyclosarin) in the Liquid Phase

Chemosensors ◽  
2019 ◽  
Vol 7 (4) ◽  
pp. 59 ◽  
Author(s):  
Martin Lobotka ◽  
Vladimír Pitschmann ◽  
Lukáš Matějovský
Keyword(s):  
Liquid Phase ◽  
Metal Complexes ◽  
Chemical Warfare Agents ◽  
Nerve Agents ◽  
Industrial Chemicals ◽  
Triphenylmethane Dyes ◽  
Detection Systems ◽  
Wide Range ◽  
Simple Detection ◽  
Warfare Agents

The paper presents the results of the study of the possibilities of using color metal complexes to detect the presence of chemical warfare agents (CWA) in liquid or aerosol form. Aluminon/Fe3+ and Eriochrome Cyanine R/Cu2+ coordination complexes and their ability to detect CWA in liquid phase are discussed. Detection systems have been demonstrated on instances of simple detection papers exposed to drops of real CWAs. Detection papers showed a positive response to G-series nerve agents and vesicant lewisite. Other liquid CWA do not interfere and the systems are also resistant to common organic solvents and a wide range of industrial chemicals.

The Potentials of Scanning Microscopy

1968 ◽  
Vol 26 ◽  
pp. 352-353
Author(s):  
A. V. Crewe
Keyword(s):  
Salient Feature ◽  
Secondary Emission ◽  
Resolving Power ◽  
X Rays ◽  
Scanning Microscope ◽  
Forming Process ◽  
Additional Tool ◽  
Detection Systems ◽  
Conventional Microscope ◽  
Present Information

If the resolving power of a scanning electron microscope can be improved until it is comparable to that of a conventional microscope, it would serve as a valuable additional tool in many investigations.The salient feature of scanning microscopes is that the image-forming process takes place before the electrons strike the specimen. This means that several different detection systems can be employed in order to present information about the specimen. In our own particular work we have concentrated on the use of energy loss information in the beam which is transmitted through the specimen, but there are also numerous other possibilities (such as secondary emission, generation of X-rays, and cathode luminescence).Another difference between the pictures one would obtain from the scanning microscope and those obtained from a conventional microscope is that the diffraction phenomena are totally different. The only diffraction phenomena which would be seen in the scanning microscope are those which exist in the beam itself, and not those produced by the specimen.

Universal ESEM

1993 ◽  
Vol 51 ◽  
pp. 786-787
Author(s):  
G.D. Danilatos
Keyword(s):  
Electron Microscope ◽  
Scanning Electron Microscope ◽  
High Vacuum ◽  
Natural Extension ◽  
Necessary Condition ◽  
Environmental Scanning ◽  
Detection Systems ◽  
Small Gain ◽  
Detection Medium ◽  
Scanning Electron

The environmental scanning electron microscope (ESEM) has evolved as the natural extension of the scanning electron microscope (SEM), both historically and technologically. ESEM allows the introduction of a gaseous environment in the specimen chamber, whereas SEM operates in vacuum. One of the detection systems in ESEM, namely, the gaseous detection device (GDD) is based on the presence of gas as a detection medium. This might be interpreted as a necessary condition for the ESEM to remain operational and, hence, one might have to change instruments for operation at low or high vacuum. Initially, we may maintain the presence of a conventional secondary electron (E-T) detector in a "stand-by" position to switch on when the vacuum becomes satisfactory for its operation. However, the "rough" or "low vacuum" range of pressure may still be considered as inaccessible by both the GDD and the E-T detector, because the former has presumably very small gain and the latter still breaks down.

Response and Reinforcement in Operant Audiometry

1987 ◽  
Vol 52 (3) ◽  
pp. 294-299 ◽  
Author(s):  
Michael A. Primus
Keyword(s):  
Operant Conditioning ◽  
Space Versus ◽  
Visual Space ◽  
Central Processing ◽  
Operant Discrimination ◽  
Conditioning Rate ◽  
Significant Difference ◽  
Simple Detection ◽  
Variable Success ◽  
Response Task

Variable success in audiometric assessment of young children with operant conditioning indicates the need for systematic examination of commonly employed techniques. The current study investigated response and reinforcement features of two operant discrimination paradigms with normal I7-month-old children. Findings indicated more responses prior to the onset of habituation when the response task was based on complex central processing skills (localization and coordination of auditory/visual space) versus simple detection. Use of animation in toy reinforcers resulted in more than a twofold increase in the number of subject responses. Results showed no significant difference in response conditioning rate or consistency for the response tasks and forms of reinforcement examined.

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