scholarly journals Maternal exposure to air pollution and congenital heart diseases in Henan, China: A register-based case-control study

2022 ◽  
Vol 229 ◽  
pp. 113070
Author(s):  
Huanhuan Zhang ◽  
Xiaoan Zhang ◽  
Xin Zhao ◽  
Guomei Cheng ◽  
Hui Chang ◽  
...  
Keyword(s):  
Air Pollution ◽  
Congenital Heart ◽  
Case Control Study ◽  
Heart Diseases ◽  
Case Control ◽  
Maternal Exposure ◽  
Congenital Heart Diseases ◽  
Control Study

scholarly journals Association Between Maternal Exposure to Indoor Air Pollution and Offspring Congenital Heart Disease: A Multi-Hospital Case-Control Study in East China

2020 ◽  
Author(s):  
Jing Sun ◽  
Jian Wang ◽  
Jing Yang ◽  
Xin Shi ◽  
Shujing Li ◽  
...  
Keyword(s):  
Air Pollution ◽  
Indoor Air ◽  
Air Pollutants ◽  
Congenital Heart ◽  
Case Control Study ◽  
Case Control ◽  
Maternal Exposure ◽  
East China ◽  
Indoor Air Pollutants ◽  
Control Study

Abstract Background: Previous research has suggested an association between maternal exposure to ambient air pollutants and the risk of congenital heart defects (CHDs). However, the effect of individual prenatal exposure to indoor air pollutants on CHD occurrence has not been reported.Methods: We carried out a hospital-based case-control study to investigate the association between personal air pollution exposure during pregnancy and the risk of CHDs in offspring. A total of 32 cases and 74 controls were included in this study from two hospitals in East China. We investigated maternal and residential environmental characteristics using a questionnaire and obtained personal indoor air samples to assess particulate matter (PM) and volatile organic compounds (VOCs) from 22–30 gestational weeks; formaldehyde, benzene, toluene, xylene, total VOCs (TVOCs), PM10, and PM2.5 were assessed. Logistic regression was performed to assess associations and interactions among individual indoor air pollutants and CHDs after adjusting for confounders. The potential residential environmental factors affecting the risks of indoor air pollutants on CHDs were also assessed.Results: Median TVOC (0.430 vs. 0.005 mg/m3, P < 0.001), PM2.5 (12.00 vs. 8.00 µg/m3, P=0.037) and PM10 (13.50 vs. 8.00 µg/m3, P=0.028) exposure levels in cases were significantly higher than those in controls. In a regression model adjusted for confounders, exposure to high levels of indoor TVOCs, PM2.5 and PM10 during pregnancy was associated with risks for CHDs and the occurrence of some major CHD subtypes in offspring. These risk effects were enhanced among pregnant woman living in a newly renovated house or near heavy-traffic roads but were mitigated by household usage of smoke ventilators when cooking. We observed a positive interaction of maternal exposure to TVOCs and PM2.5 in regard to the risk for CHDs.Conclusions: Maternal exposure to indoor VOCs and PMs may increase the risk of giving birth to foetuses with CHDs.

scholarly journals Association Between Maternal Exposure to Indoor Air Pollution and Offspring Congenital Heart Disease: A Multi-Hospital Case-Control Study in East China

2021 ◽  
Author(s):  
Jing Sun ◽  
Jian Wang ◽  
Jing Yang ◽  
Xin Shi ◽  
Shujing Li ◽  
...  
Keyword(s):  
Air Pollution ◽  
Indoor Air ◽  
Air Pollutants ◽  
Congenital Heart ◽  
Case Control Study ◽  
Case Control ◽  
Maternal Exposure ◽  
East China ◽  
Indoor Air Pollutants ◽  
Control Study

Abstract Background Previous research has suggested an association between maternal exposure to ambient air pollutants and the risk of congenital heart defects (CHDs). However, the effect of individual prenatal exposure to indoor air pollutants on CHD occurrence has not been reported. Methods We carried out a hospital-based case-control study to investigate the association between personal air pollution exposure during pregnancy and the risk of CHDs in offspring. A total of 34 cases and 72 controls were included in this study from two hospitals in East China. We investigated maternal and residential environmental characteristics using a questionnaire and obtained personal indoor air samples to assess particulate matter (PM) and volatile organic compounds (VOCs) from 22–30 gestational weeks; formaldehyde, benzene, toluene, xylene, total VOCs (TVOCs), PM10, and PM2.5 were assessed. Logistic regression was performed to assess associations and interactions among individual indoor air pollutants and CHDs after adjusting for confounders. The potential residential environmental factors affecting the risks of indoor air pollutants on CHDs were also assessed. Results Median TVOC (0.430 vs. 0.005 mg/m3, P < 0.001), PM2.5 (12.00 vs. 8.00 µg/m3, P = 0.037) and PM10 (13.50 vs. 8.00 µg/m3, P = 0.028) exposure levels in cases were significantly higher than those in controls. In a regression model adjusted for confounders, exposure to high levels of indoor TVOCs, PM2.5 and PM10 during pregnancy was associated with risks for CHDs and the occurrence of some major CHD subtypes in offspring. These risk effects were enhanced among pregnant woman living in a newly renovated house or near heavy-traffic roads but were mitigated by household usage of smoke ventilators when cooking. We observed a positive interaction of maternal exposure to TVOCs and PM2.5 in regard to the risk for CHDs. Conclusions Maternal exposure to indoor VOCs and PMs may increase the risk of giving birth to foetuses with CHDs.

Congenital heart diseases and parental occupational exposure in a Hungarian case‐control study in 1997 to 2002

2020 ◽  
Author(s):  
Vince Fazekas‐Pongor ◽  
Melinda Csáky‐Szunyogh ◽  
Mónika Fekete ◽  
Ágota Mészáros ◽  
Károly Cseh ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Congenital Heart ◽  
Case Control Study ◽  
Heart Diseases ◽  
Case Control ◽  
Congenital Heart Diseases ◽  
Hungarian Case ◽  
Parental Occupational Exposure ◽  
Control Study

scholarly journals Maternal exposure to life events during pregnancy and congenital heart disease in offspring: a case-control study in a Chinese population

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jing Li ◽  
Yujiao Du ◽  
Yini Liu ◽  
Jiaoyang Du ◽  
Ruo Zhang ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Pregnant Women ◽  
Life Events ◽  
Congenital Heart ◽  
Case Control Study ◽  
Case Control ◽  
Maternal Exposure ◽  
Negative Events ◽  
Positive Events ◽  
Control Study

Abstract Background Previous studies have suggested that maternal stress could increase the risk of some adverse pregnancy outcomes, but evidence on congenital heart disease (CHD) is limited. We aimed to explore the association between maternal exposure to life events during pregnancy and CHD in offspring. Methods The data was based on an unmatched case-control study about CHD conducted in Shaanxi province of China from 2014 to 2016. We included 2280 subjects, 699 in the case group and 1581 in the control group. The cases were infants or fetuses diagnosed with CHD, and the controls were infants without any birth defects. The life events were assessed by the Life Events Scale for Pregnant Women, and were divided into positive and negative events for synchronous analysis. A directed acyclic graph was drawn to screen the confounders. Logistic regression was employed to estimate the odds ratio and 95% confidence interval for the effects of life events on CHD. Results After controlling for the potential confounders, the pregnant women experiencing the positive events during pregnancy had lower risk of CHD in offspring than those without positive events (OR = 0.38, 95%CI: 0.30 ~ 0.48). The risk of CHD in offspring could increase by 62% among the pregnant women experiencing the negative events compared to those without (OR = 1.62, 95%CI: 1.29 ~ 2.03). Both effects showed a certain dose-response association. Besides, the positive events could weaken the risk impact of negative events on CHD. Conclusion It may suggest that maternal exposure to negative life events could increase the risk of CHD in offspring, while experiencing positive events could play a potential protective role.

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