scholarly journals Pregnancy exposure to phthalates and DNA methylation in male placenta — An epigenome-wide association study

2022 ◽  
Vol 160 ◽  
pp. 107054
Author(s):  
Paulina Jedynak ◽  
Jörg Tost ◽  
Antonia M. Calafat ◽  
Ekaterina Bourova-Flin ◽  
Lucile Broséus ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Association Study

scholarly journals Epigenome-wide association study of whole blood gene expression in Framingham Heart Study participants provides molecular insight into the potential role of CHRNA5 in cigarette smoking-related lung diseases

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Chen Yao ◽  
Roby Joehanes ◽  
Rory Wilson ◽  
Toshiko Tanaka ◽  
Luigi Ferrucci ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Dna Methylation ◽  
Cigarette Smoking ◽  
Association Study ◽  
Whole Blood ◽  
Lung Diseases ◽  
Epigenetic Modification ◽  
Blood Gene Expression ◽  
Increased Risk

Abstract Background DNA methylation is a key epigenetic modification that can directly affect gene regulation. DNA methylation is highly influenced by environmental factors such as cigarette smoking, which is causally related to chronic obstructive pulmonary disease (COPD) and lung cancer. To date, there have been few large-scale, combined analyses of DNA methylation and gene expression and their interrelations with lung diseases. Results We performed an epigenome-wide association study of whole blood gene expression in ~ 6000 individuals from four cohorts. We discovered and replicated numerous CpGs associated with the expression of cis genes within 500 kb of each CpG, with 148 to 1,741 cis CpG-transcript pairs identified across cohorts. We found that the closer a CpG resided to a transcription start site, the larger its effect size, and that 36% of cis CpG-transcript pairs share the same causal genetic variant. Mendelian randomization analyses revealed that hypomethylation and lower expression of CHRNA5, which encodes a smoking-related nicotinic receptor, are causally linked to increased risk of COPD and lung cancer. This putatively causal relationship was further validated in lung tissue data. Conclusions Our results provide a large and comprehensive association study of whole blood DNA methylation with gene expression. Expression platform differences rather than population differences are critical to the replication of cis CpG-transcript pairs. The low reproducibility of trans CpG-transcript pairs suggests that DNA methylation regulates nearby rather than remote gene expression. The putatively causal roles of methylation and expression of CHRNA5 in relation to COPD and lung cancer provide evidence for a mechanistic link between patterns of smoking-related epigenetic variation and lung diseases, and highlight potential therapeutic targets for lung diseases and smoking cessation.

scholarly journals Residential surrounding greenness and DNA methylation: An epigenome-wide association study

2021 ◽  
Vol 154 ◽  
pp. 106556
Author(s):  
Rongbin Xu ◽  
Shuai Li ◽  
Shanshan Li ◽  
Ee Ming Wong ◽  
Melissa C. Southey ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Association Study

scholarly journals A Genome-Wide Integrative Association Study of DNA Methylation and Gene Expression Data and Later Life Cognitive Functioning in Monozygotic Twins

2020 ◽  
Vol 14 ◽  
Author(s):  
Mette Soerensen ◽  
Dominika Marzena Hozakowska-Roszkowska ◽  
Marianne Nygaard ◽  
Martin J. Larsen ◽  
Veit Schwämmle ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Cognitive Functioning ◽  
Association Study ◽  
Gene Expression Data ◽  
Monozygotic Twins ◽  
Later Life ◽  
Expression Data ◽  
Genome Wide ◽  
A Genome

THU0454 Changes in DNA Methylation Related to Smoking Are Associated with Ra. an Epigenome Wide Association Study in Monozygotic RA Discordant Twin Pairs

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 340.2-340
Author(s):  
A.J. Svendsen ◽  
K. Gervin ◽  
R. Lyle ◽  
C. Nielsen ◽  
G. Houen ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Association Study ◽  
Discordant Twin

scholarly journals Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

2015 ◽  
Vol 47 (11) ◽  
pp. 1282-1293 ◽  
Author(s):  
Norihiro Kato ◽  
◽  
Marie Loh ◽  
Fumihiko Takeuchi ◽  
Niek Verweij ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Dna Methylation ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genetic Loci ◽  
Genome Wide

scholarly journals Pregnancy exposure to synthetic phenols and placental DNA methylation - An epigenome-wide association study in male infants from the EDEN cohort

2021 ◽  
pp. 118024
Author(s):  
Paulina Jedynak ◽  
Jörg Tost ◽  
Antonia M. Calafat ◽  
Ekaterina Bourova-Flin ◽  
Florence Busato ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Association Study

scholarly journals Grandmaternal stress during pregnancy and DNA methylation of the third generation: an epigenome-wide association study

2017 ◽  
Vol 7 (8) ◽  
pp. e1202-e1202 ◽  
Author(s):  
F Serpeloni ◽  
K Radtke ◽  
S G de Assis ◽  
F Henning ◽  
D Nätt ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Association Study ◽  
Third Generation ◽  
The Third

scholarly journals Differential DNA methylation and PM2.5 species in a 450K epigenome-wide association study

Epigenetics ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. 139-148 ◽  
Author(s):  
Lingzhen Dai ◽  
Amar Mehta ◽  
Irina Mordukhovich ◽  
Allan C. Just ◽  
Jincheng Shen ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Association Study

scholarly journals An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Mark W. Logue ◽  
◽  
Mark W. Miller ◽  
Erika J. Wolf ◽  
Bertrand Russ Huber ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Posttraumatic Stress Disorder ◽  
Association Study ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Us Veterans
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