Metabolomics-based molecular signatures reveal the toxic effect of co-exposure to nitrosamines in drinking water

2022 ◽  
Vol 204 ◽  
pp. 111997
Author(s):  
Chao Zhao ◽  
Hu Zhang ◽  
Jingjing Zhou ◽  
Qiang Lu ◽  
Ying Zhang ◽  
...  
Keyword(s):  
Drinking Water ◽  
Toxic Effect ◽  
Molecular Signatures

Histopathological alterations of selenium toxicity induced in broiler (Birds)

2017 ◽  
Author(s):  
Avnish Kumar Gautam ◽  
Deepak Kumar ◽  
Manoj Kumar Sinha
Keyword(s):  
Drinking Water ◽  
Toxic Effect ◽  
Cell Volume ◽  
Packed Cell Volume ◽  
Sodium Selenite ◽  
Biochemical Parameter ◽  
Lymphoid Cells ◽  
Bursa Of Fabricius ◽  
White Leghorn ◽  
Group A

A study was conducted to determine the pathological toxic effect of selenium (Sodium selenite). A total number 120 one day old White Leghorn (WLH) healthy broiler birds were randomly divided into A, B and C groups. Each group contain 40 birds daily administration of sodium selenite @ 30ppm and @ 15 ppm in group A and B, respectively and group C was given plain drinking water daily for 42 days and kept as control. Macroscopically and microscopically revealed varying degrees of congestion and haemorrhages in lungs, liver, kidneys, heart and intestine in selenium treated birds. The bursa of Fabricius showed depletion of lymphoid cells between the interfollicular spaces. A significant (P less than 0.05) decrease in the haemoglobin and packed cell volume was noticed in both the selenium fed groups but the total erythrocyte count remain unchanged. Biochemical parameter revealed slight decline in their activity of serum ALT and AST and increased level of BUN and creatinine in group A and B as compared to group C, suggesting some degree of renal dysfunctioning.

scholarly journals Toxic effect of poly(hexamethylene guanidine) on diatom algae

2020 ◽  
pp. 1076-1079
Author(s):  
V.V. Annenkov ◽  
◽  
E.N. Danilovtseva ◽  
V.A. Palshin ◽  
T.N. Avezova ◽  
...  
Keyword(s):  
Drinking Water ◽  
Acrylic Acid ◽  
Toxic Effect ◽  
Aquatic Ecosystems ◽  
Complete Suppression ◽  
Organic Substances ◽  
Diatom Algae ◽  
Domestic Use ◽  
Synedra Acus ◽  
First Time

Poly(hexamethylene guanidine) has been used for several decades as a disinfectant for various surfaces and water, including drinking water. Its use has increased significantly due to the COVID-19 pandemic. The toxicity of poly(hexamethylene guanidine) has been studied on warmblooded animals and fish, but there is little data on its action on planktonic organisms. For the first time the effect of poly(hexamethylene guanidine) (Anavidin preparation) on diatom algae which are one of the main producers of oxygen and photosynthesized organic substances was studied. The obtained data indicate complete suppression of the growth of the diatom Ulnaria ferefusiformis (formerly known as Synedra acus) at a concentration of 0.5 mg/L. Diatom growth is suppressed by more than 30% at 0.1 mg/L Anavidin, which corresponds to the MAC for water bodies for household and domestic use. Addition of polymeric acids, for example, poly(acrylic acid) partially neutralizes the toxic effect of poly(hexamethylene guanidine). Thus, due to the widespread use of poly(hexamethylene guanidine), it is necessary to thoroughly study its effect on various inhabitants of aquatic ecosystems.

Zinc Impurity in Drinking Water and Its Toxic Effect on Human Health

2019 ◽  
Vol 17 (4) ◽  
pp. 84
Author(s):  
Mahipal Singh Sankhla ◽  
Rajeev Kumar ◽  
Lalit Prasad
Keyword(s):  
Drinking Water ◽  
Toxic Effect ◽  
Human Health

scholarly journals Original Article. Toxic effect of sodium fluoride on hydroxyproline level and expression of collagen-1 gene in rat bone and its amelioration by Tamrindus indica L. fruit pulp extract

2016 ◽  
Vol 9 (1) ◽  
pp. 12-16 ◽  
Author(s):  
Amit Raj Gupta ◽  
Sahadeb Dey ◽  
Mohini Saini ◽  
Devendra Swarup
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Toxic Effect ◽  
Sodium Fluoride ◽  
Albino Rats ◽  
Continuous Exposure ◽  
Collagen Gene ◽  
Fruit Pulp ◽  
Rat Bone

Abstract Excessive fluoride intoxication plays an important role in the development of dental, skeletal and non-skeletal fluorosis. The aim of this study was to ascertain the toxic effect of excessive fluoride ingestion on the level of hydroxyproline and expression of type 1 collagen gene in rat bone and its amelioration by supplementation with Tamarindus indica fruit pulp extract. Forty albino rats were randomly assigned to four groups. The first group served as control and received only tap water. The second group received sodium fluoride (200 ppm) through drinking water. The third group received T. indica fruit pulp extract (200 mg/kg body weight) alone and the fourth group received the T. indica fruit pulp extract (200 mg/kg body weight) along with fluorinated drinking water (200 ppm) daily by gavage for a period of 90 days. The level of hydroxyproline and expression of type 1 collagen gene using quantitative real time PCR in the tibia bone decreased significantly with continuous exposure to sodium fluoride. Co-administration of T. indica fruit pulp extract during exposure to fluoride through drinking water restored the level of calcium, phosphorus and alkaline phosphatase in serum and the concentration of hydroxyproline in urine. It increased the level of hydroxyproline and expression of type 1 collagen gene in the tibia as compared to untreated fluoride-exposed rats. It is concluded that T. indica fruit pulp extract has an ameliorative potential to protect the bone from fluoride induced collagen damage.

Habitat Association of Klebsiella Species

1985 ◽  
Vol 6 (2) ◽  
pp. 52-58 ◽  
Author(s):  
Susan T. Bagley
Keyword(s):  
Drinking Water ◽  
Gastrointestinal Tract ◽  
Surface Waters ◽  
Industrial Effluents ◽  
Opportunistic Pathogen ◽  
Habitat Associations ◽  
Habitat Association ◽  
Klebsiella Species ◽  
Almost All ◽  
Polluted Waters

AbstractThe genus Klebsiella is seemingly ubiquitous in terms of its habitat associations. Klebsiella is a common opportunistic pathogen for humans and other animals, as well as being resident or transient flora (particularly in the gastrointestinal tract). Other habitats include sewage, drinking water, soils, surface waters, industrial effluents, and vegetation. Until recently, almost all these Klebsiella have been identified as one species, ie, K. pneumoniae. However, phenotypic and genotypic studies have shown that “K. pneumoniae” actually consists of at least four species, all with distinct characteristics and habitats. General habitat associations of Klebsiella species are as follows: K. pneumoniae—humans, animals, sewage, and polluted waters and soils; K. oxytoca—frequent association with most habitats; K. terrigena— unpolluted surface waters and soils, drinking water, and vegetation; K. planticola—sewage, polluted surface waters, soils, and vegetation; and K. ozaenae/K. rhinoscleromatis—infrequently detected (primarily with humans).

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