Cognitive Outcomes Following Pediatric Epilepsy Surgery

2022 ◽  
pp. 106859
Author(s):  
Navkiranjot Kaur ◽  
Amy S. Nowacki ◽  
Jennifer S. Haut ◽  
Patricia Klaas ◽  
Lisa Ferguson ◽  
...  
2019 ◽  
Vol 10 ◽  
pp. 257 ◽  
Author(s):  
Nisha Gadgil ◽  
Melissa A. LoPresti ◽  
Matthew Muir ◽  
Jeffrey M. Treiber ◽  
Marc Prablek ◽  
...  

Epilepsy affects many children worldwide, with drug-resistant epilepsy affecting 20–40% of all children with epilepsy. This carries a significant burden for patients and their families and is strongly correlated with poor cognitive outcomes, depression, anxiety, developmental delay, and impaired activities of daily living. For this reason, we sought to explore the role of pediatric epilepsy surgery and provide an overview of the factors contributing to epilepsy surgery planning and execution. We review the necessary preoperative evaluations, surgical indications, planning considerations, and surgical options to provide a clear pathway in the evaluation and planning of pediatric epilepsy surgery.


2010 ◽  
Vol 32 (26) ◽  
pp. 1-6
Author(s):  
Sanjiv Bhatia ◽  
John Ragheb

Epilepsia ◽  
2010 ◽  
Vol 51 (10) ◽  
pp. 2089-2097 ◽  
Author(s):  
Lucyna M. Lach ◽  
Irene Elliott ◽  
Tiffany Giecko ◽  
Janet Olds ◽  
Thomas Snyder ◽  
...  

2009 ◽  
Vol 26 (5) ◽  
pp. 675-679 ◽  
Author(s):  
Wai Hoe Ng ◽  
Ayako Ochi ◽  
James T. Rutka ◽  
Samuel Strantzas ◽  
Laura Holmes ◽  
...  

2017 ◽  
Vol 32 (5) ◽  
pp. 467-474 ◽  
Author(s):  
Krista J. Qualmann ◽  
Christine G. Spaeth ◽  
Melanie F. Myers ◽  
Paul S. Horn ◽  
Katherine Holland ◽  
...  

Central nervous system comorbidities have been identified in patients with epilepsy. Several of these comorbidities have been correlated with poor surgery outcomes in patient cohorts. The authors sought to determine if prevalence of comorbidities in pediatric epilepsy surgery patients and their families correlate with long-term seizure outcome in a cross-sectional analysis. Three-generation pedigrees were elicited to compare family history of epilepsy, ADHD, anxiety, autism, bipolar disorder, cognitive disability, depression, migraine, and motor disability to surgery outcomes in 52 patients. Proportions of affected patients and relatives were compared to general population comorbidity rates and the patients’ most recent seizure outcome classification. Patients and families had significantly higher rates of comorbidities than the general population. Poorer long-term seizure outcomes following resective surgery were associated with autism or cognitive disability in patients. Together these data support evidence for a common pathophysiological mechanism between epilepsy and central nervous system comorbidities.


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