Abstract #1004339: Thymic Hyperplasia and Graves’ Disease

2021 ◽  
Vol 27 (6) ◽  
pp. S182-S183
Author(s):  
Cory DeClue ◽  
Bhavana Chinnakotla
2019 ◽  
Author(s):  
Ana Majic ◽  
Mirjana Kardum Pejic ◽  
Josip Pejic

Author(s):  
Mehreen Anwar ◽  
Athar Iqbal Khan Muhammad ◽  
Muhammad Shoaib Khan Sardar ◽  
Yamin thant ◽  
Steve G. Jones ◽  
...  

2020 ◽  
Vol 133 (3) ◽  
pp. 308-310
Author(s):  
Michael Voss ◽  
Zeb Ijaz Saeed ◽  
Diane Donegan

1971 ◽  
Vol 32 (2) ◽  
pp. 140-146 ◽  
Author(s):  
A. J. VAN HERLE ◽  
I. J. CHOPRA

2020 ◽  
Vol 6 (3) ◽  
pp. e144-e146
Author(s):  
WingYee Wan ◽  
Jeffrey A. Colburn

Objective: Graves disease (GD) has a well-known association with thymic hyperplasia, which is seen histo-logically in up to 38% of patients with GD. However, there have only been approximately 100 documented cases of Graves-associated massive thymic hyperplasia. Potential mechanisms of thymic pathology are reviewed. Methods: A 24-year-old female presented to the emergency department with dyspnea, palpitations, tachycardia, anxiety, and weight loss. She was evaluated for hyperthyroidism using labs (thyroid-stimulating hormone, free thyroxine, thyroid-stimulating immunoglobulins) and imaging (radioactive iodine uptake [RAIU] scan), leading to treatment with radioiodine. A computed tomography angiogram of the chest was also performed to evaluate for pulmonary embolism given the patient's presenting symptoms. Results: Our patient was found to have undetectable thyroid-stimulating hormone, elevated free thyroxine (2.9 ng/dL), and elevated thyroid-stimulating immunoglobulins (399%). Diagnosis of GD was confirmed on RAIU scan. The computed tomography chest angiogram demonstrated a significant anterior mediastinal mass (7.9 × 6.9 × 6.3 cm). Treatment with radioiodine led to reduction of the mass by 76% in volume. Conclusion: While the patient's thyroid labs and RAIU scan were consistent with GD, the presence of massive thymic hyperplasia was atypical. However, the resolution of thymic hyperplasia after radioiodine therapy, without the use of thymectomy, was similar to other reported cases.


1996 ◽  
Vol 72 (3) ◽  
pp. 467-472 ◽  
Author(s):  
Mihoko TAKEUCHI ◽  
Kenzo UCHIDA ◽  
Takashi ISHII ◽  
Mitsutaka KITAZAWA ◽  
Toshikazu KIGOSHI ◽  
...  

2019 ◽  
Vol 08 (01) ◽  
pp. e24-e26 ◽  
Author(s):  
Christopher James Kennedy ◽  
David James William Paton

Background Thymic hyperplasia is a recognized complication of Graves' disease that can present radiologically as an anterior mediastinal mass. Case Description We present a unique case of massive thymic hyperplasia occurring in a 24-year-old female without a known history of thyroid or other systemic disease in whom Graves' disease first manifested intraoperatively during thymectomy for presumed neoplasia. Conclusion We suggest that the work-up of all anterior mediastinal masses should include a comprehensive search for medical causes of reversible thymic enlargement.


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