Ipidacrine (Axamon), A Reversible Cholinesterase Inhibitor, Improves Erectile Function in Male Rats With Diabetes Mellitus-Induced Erectile Dysfunction

ABSTRACT: Stroke is a big health problem in all industrial nations. In Indonesia, the prevalence of stroke keeps on increasing with each passing year. In addition to physical complaints suffered, sexual function may affect the patient’s. Erectile dysfunction is a problem that often arises in stroke patients. Purpose: This research is aimed in understanding describe of erectile dysfunction and the relationship between the risk factor namely diabetes mellitus and hypertension among stroke patients. Methods: The research method used is analytic descriptive with cross sectional approach. The study subjects were 40 men stroke patients, recruited by consecutive sampling in Polyclinic Neurology RSUP Prof. Dr. R. D. Kandou Manado during the period of November to December 2013. The measurement of erectile dysfunction used International Index of Erectile function/IIEF-5. Conclusion: Stroke patients who experience erectile dysfunction by 85%, with the highest amount on mild erectile dysfunction and mild to moderate erectile dysfunction at 35% dan 32,5%. Age most experienced erectile dysfunction are in the age group 35-44 years and >75 years. Low levels of education may suffer from erectile dysfunction is higher than the high education level. And the insiden of erectile dysfunction among stroke patients having risk factor of diabetes mellitus were higher than haven’t (OR=2,391). While hypertension risk factors correlated with a reduced risk of disease (OR=0,771). Keywords: Stroke, erectile dysfunction, diabetes mellitus, hypertension ABSTRAK: Stroke merupakan masalah kesehatan yang besar di negara-negara industri, prevalensi stroke di Indonesia terus meningkat dari tahun ke tahun. Selain keluhan fisik yang diderita, keadaan fungsi seksual dapat mempengaruhi penderita. Disfungsi ereksi merupakan masalah yang sering timbul pada pasien stroke. Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran disfungsi ereksi dan hubungan diabetes melitus dan hipertensi terhadap kejadian disfungsi ereksi pada pasien stroke. Metode: Jenis penelitian yang digunakan adalah deskriptif analitik dengan pendekatan cross sectional. Jumlah sampel sebanyak 40 pasien stroke laki-laki yang diambil secara consecutive sampling di Poliklinik Neurologi RSUP Prof. Dr. R. D. Kandou Manado selama bulan November - Desember 2013. Pengukuran disfungsi ereksi menggunakan International Index of Erectile Function/IIEF-5. Simpulan: Pasien stroke yang mengalami disfungsi ereksi sebesar 85% dengan jumlah terbanyak pada disfungsi ereksi ringan dan disfungsi ereksi ringan sampai sedang sebesar 35% dan 32,5%. Umur terbanyak mengalami disfungsi ereksi terletak pada kelompok umur 35-44 tahun dan >75 tahun. Tingkat pendidikan rendah dapat mengalami disfungsi ereksi lebih tinggi daripada yang tingkat pendidikannya tinggi. Dan insiden disfungsi ereksi diantara pasien stroke yang mempunyai faktor resiko diabetes melitus adalah lebih tinggi daripada yang tidak mempunyai faktor resiko tersebut (OR=2,391). Sedangkan faktor resiko hipertensi berkorelasi dengan berkurangnya resiko penyakit (OR=0,771). Kata Kunci: Stroke, disfungsi ereksi, diabetes melitus, hipertensi

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Predictors of Erectile Dysfunction in Men with Type 2 Diabetes Mellitus Referred to a Tertiary Healthcare Centre

Advances in Endocrinology ◽

10.1155/2016/9753154 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 5

Author(s):

Theophilus Ugwu ◽

Ignatius Ezeani ◽

Samuel Onung ◽

Babatope Kolawole ◽

Rosemary Ikem

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Erectile Dysfunction ◽

Glycemic Control ◽

Autonomic Neuropathy ◽

Erectile Function ◽

Poor Glycemic Control ◽

Testosterone Deficiency ◽

Tertiary Healthcare

Background. The frequency of erectile dysfunction (ED) complicating diabetes mellitus (DM) is reportedly high. However, its risk factors have not been well studied. Methods. This was a cross-sectional study of 160 male type 2 DM adults, aged 30–70 years, attending a tertiary healthcare clinic. Demographic and relevant clinical information was documented. Erectile function was assessed using an abridged version of the International Index of Erectile Function (IIEF-5). All subjects were evaluated for central obesity, glycemic control, peripheral arterial disease (PAD), autonomic neuropathy, dyslipidemia, and testosterone deficiency. Results. 152 (95%) patients with a mean age of 60.3 ± 8.8 years completed the study. 71.1% had varying degrees of ED, while 58.3% suffered from a moderate-to-severe form. Independent predictors of ED [presented as adjusted odds ratio (95% confidence interval)] were longer duration of DM, 1.14 (1.02–1.28), PAD, 3.87 (1.28–11.67), autonomic neuropathy, 3.51 (1.82–6.79), poor glycemic control, 7.12 (2.49–20.37), and testosterone deficiency, 6.63 (2.61–16.83). Conclusion. The prevalence of ED and its severe forms was high in this patient population. Poor glycemic control and testosterone deficiency were the strongest risk factors for ED, making it possibly a preventable condition.

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Role of oxidative stress, adiponectin and endoglin in the pathophysiology of erectile dysfunction in diabetic and non-diabetic men

Physiological Research ◽

10.33549/physiolres.934129 ◽

2019 ◽

pp. 623-631 ◽

Cited By ~ 1

Author(s):

B. Trebatický ◽

I. Žitňanová ◽

M. Dvořáková ◽

Z. Országhová ◽

Z. Paduchová ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Erectile Dysfunction ◽

Endothelial Dysfunction ◽

Erectile Function ◽

Protein Carbonyls ◽

Relaxation Processes ◽

Reactive Protein ◽

Glycation End Products

Erectile dysfunction (ED) and diabetes mellitus (DM) share common pathophysiological risk factors including endothelial dysfunction which together with hyperglycemia contribute to the increased oxidative/glycooxidative stress. A reduced NO concentration is insufficient for relaxation processes in the penis. Chronic inflammation and endoglin are involved in the regulation of endothelial function. Adiponectin from the adipose tissue has anti-inflammatory effects. Our study aimed to investigate the relation between erectile function in patients with and without DM and the oxidative stress, hormone adiponectin, and endothelial dysfunction marker endoglin. Men (n=32) with ED evaluated by the International Index of Erectile function (IIEF-5) questionnaire (17 without DM (NDM); 15 with type 2 diabetes mellitus (DM)) and 31 controls were included. Advanced glycation end products (AGEs), 8-isoprostanes (8-isoP), protein carbonyls, antioxidant capacity, adiponectin and endoglin were determined in the blood. DM patients compared to NDM patients and controls, had increased levels of glucose, C-reactive protein, triacylglycerols, 8-isoP, AGEs, endoglin and BMI. IIEF-5 score, NO and adiponectin levels were decreased. We are the first to find out that endoglin shows a negative correlation with erectile function in NDM, but not in DM patients. Endoglin can be considered as endothelial dysfunction marker in nondiabetic men suffering from ED.

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Pengaruh Diabetes Mellitus Terhadap Kejadian Disfungsi Ereksi

Jurnal e-Biomedik ◽

10.35790/ebm.v9i2.31783 ◽

2021 ◽

Vol 9 (2) ◽

Author(s):

Alpacino J. Wowor ◽

Lydia E. N. Tendean ◽

Janette M. Rumbajan

Keyword(s):

Diabetes Mellitus ◽

Erectile Dysfunction ◽

Literature Review ◽

Sexual Health ◽

Erectile Function ◽

Communicable Disease ◽

The Elderly ◽

Exclusion Criteria ◽

Sugar Levels ◽

Non Communicable Disease

Abstract: Diabetes Mellitus (DM) is a non-communicable disease that can be found at all ages, especially in adults and the elderly. Erectile Dysfunction (ED) is the inability to maintain an erection. Like DM, DE is still a problem facing the world, including Indonesia. Blood vessels can be damaged by various factors, one of which is uncontrolled blood sugar levels that can lead to Erectile Dysfunction. The International Index of Erectile Function (IIEF-5) or Sexual Health Inventory for Men (SHIM) is a tool for diagnosing ED. The purpose of this study was to determine the effect of Diabetes Mellitus on the incidence of Erectile Dysfunction. This study took the form of a literature review with data searches using three databases, namely Pubmed, ScienceDirect and Google Scholar. The keywords used were Diabetes Mellitus "AND" Erectile Dysfunction. 10 literature was obtained after being selected based on inclusion and exclusion criteria. According to the ten literature selected in this study, all found an effect of Diabetes Mellitus on the incidence of Erectile Dysfunction. In Conclusion, Diabetes Mellitus affects the occurrence of Erectile Dysfunction.Keywords: Diabetes Mellitus, Erectile Dysfunction. Abstrak: Diabetes Mellitus (DM) merupakan penyakit tidak menular yang dijumpai pada segala usia terutama pada dewasa dan lansia. Disfungsi Ereksi (DE) merupakan ketidakmampuan dalam mempertahankan ereksi. Seperti halnya DM, DE juga masih menjadi masalah yang dihadapi dunia termasuk Indonesia. Pembuluh darah dapat mengalami kerusakan oleh berbagai faktor, salah satunya adalah kadar gula darah yang tidak terkontrol sehingga dapat memicu terjadinya Disfungsi Ereksi. International Index of Erectile Function (IIEF-5) atau Sexual Health Inventory for Men (SHIM) merupakan alat bantu dalam penegakan diagnosis DE. Tujuan penelitian ini adalah untuk mengetahui pengaruh Diabetes Mellitus terhadap kejadian Disfungsi Ereksi. Penelitian ini berbentuk literature review dengan pencarian data menggunakan tiga database, yaitu Pubmed, ScienceDirect dan Google Cendekia. Kata kunci yang digunakan yaitu Diabetes Mellitus “DAN” Erectile Dysfunction. Didapatkan 10 literatur setelah diseleksi berdasarkan kriteria inklusi dan eksklusi. Berdasarkan dari sepuluh literatur yang dipilih dalam penelitian ini, seluruhnya mendapati adanya pengaruh Diabetes Mellitus terhadap kejadian Disfungsi Ereksi. Sebagai simpulan, Diabetes Mellitus berpengaruh terhadap terjadinya Disfungsi Ereksi.Kata kunci: Diabetes Mellitus, Disfungsi Ereksi.

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Efficacy and safety of PDE5 inhibitors in the treatment of diabetes mellitus erectile dysfunction: a systematic review and meta-analysis

10.21203/rs.2.10685/v1 ◽

2019 ◽

Author(s):

Xiao Li ◽

Qi Zhao ◽

Jingshang Wang ◽

Jisheng Wang ◽

Hengheng Dai ◽

...

Keyword(s):

Diabetes Mellitus ◽

Erectile Dysfunction ◽

Erectile Function ◽

Assessment Tool ◽

Meta Analysis ◽

Knowledge Network ◽

Cochrane Library ◽

Efficacy And Safety ◽

Pde5 Inhibitors ◽

Data Resource

Abstract ABSTRACT Background: To systematically evaluate the efficacy and safety of the PDE5 inhibitors in patients with diabetes mellitus erectile dysfunction (DMED). Methods:Random control trials (RCTs) in PubMed, EMBASE, Cochrane library, ClinicalTrials, China Knowledge Network (CNKI), Weipu Chinese Science and Technology Journal Full-text Database (VIP), Wanfang Data Resource System (WANFANG) were searched. Two researchers independently screened the literature, extracted the data and checked the results, and used the risk assessment tool to conduct a methodological quality assessment, and finally conducted a meta-analysis. The primary outcome, the erectile function scores of the International Index of Erectile Dysfunction (IIEF-EF), was recorded, while secondary outcomes (IIEF-Q3, IIEF-Q4, SEP 2 and 3, GAQ) and safety outcomes also needed attention. Results: Twelve studies included 3,124 patients and six PDE5 inhibitors were included. Compared with placebo, PDE5 inhibitors significantly improved male erectile function in IIEF-EF (WMD = 5.73; 95% CI: 3.62 to 7.84), IIEF-Q3 (WMD = 1.14; 95% CI: 0.87 to 1.40), IIEF-Q4 (WMD=1.28; 95% CI: 1.04 to 1.51), SEP2 (WMD=21.24; 95% CI: 15.50 to 26.98), SEP3 (WMD=25.77; 95% CI: 18.78 to 32.77), GAQ (RR) =2.98; 95% CI: 2.06 to 4.32), and with the safety (WMD=5.73; 95% CI: 3.62 to 7.84). Conclusions: PDE5 inhibitors can significantly improve the patient's erectile function, but cannot ignore their side effects.

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PENGARUH LAMANYA DIABETES MELITUS TERHADAP TERJADINYA DISFUNGSI EREKSI

Jurnal e-Biomedik ◽

10.35790/ebm.1.3.2013.3582 ◽

2013 ◽

Vol 1 (3) ◽

Author(s):

Natasya Juliani Dodie ◽

Lydia Tendean ◽

Benny Wantouw

Keyword(s):

Diabetes Mellitus ◽

Erectile Dysfunction ◽

Random Sampling ◽

Erectile Function ◽

Univariate Analysis ◽

Simple Random Sampling ◽

T Test ◽

Cross Sectional ◽

Duration Of Diabetes ◽

Diabetes Melitus

Abstract: Diabetes mellitus is a condition with excess glucose in the blood which can lead to complications such as chronic diseases, among others cardiovascular disease and sexual dysfunction such as erectile dysfunction. This study aimed to determine the effect of duration of diabetes mellitus on the occurrence of erectile dysfunction. This was an analytic survey with cross sectional study design. Samples were 30 respondents, taken by simple random sampling. Data were collected by using a questionnaire IIEF-5 (International Index of Erectile Function) and the data were univariate analyzed. The results showed that there were 20 people suffered from erectile dysfunction out of 30 respondents. The univariate analysis showed that erectile dysfunction respondents that had diabetes mellitus for 1-4 years were 11 people (36.7%); and that had diabetes mellitus for 5-8 years were 19 people (63.3%). The statistical parametric test T-Test found a significant relationship between the duration of diabetes mellitus and erectile dysfunction with P = 0.025 (a significance level of 0.05). Conclusion: Long duration of diabetes mellitus can lead to erectile dysfunction. Keywords: diabetes mellitus, erectile dysfunction. Abstrak: Diabetes melitus adalah suatu keadaan dimana terdapat kadar gula berlebihan dalam darah yang dapat mengakibatkan komplikasi berupa penyakit-penyakit kronis seperti penyakit kardiovaskuler dan disfungsi seksual, salah satunya disfungsi ereksi. Penelitian ini bertujuan untuk mengetahui pengaruh lamanya diabetes melitus terhadap terjadinya disfungsi ereksi. Penelitian ini bersifat survei analitik dengan desain penelitian cross sectional. Sampel berjumlah 30 orang yang diambil secara simple random sampling. Data dikumpulkan dengan menggunakan kuesioner IIEF-5 (International Index of Erectile Function) dan data dianalisis secara univariat. Dari penelitian ini didapatkan 20 orang dengan kejadian disfungsi ereksi pada penderita diabetes melitus dari 30 orang responden. Analisa univariat menunjukkan bahwa responden yang mengalami disfungsi ereksi pada pria dengan diabetes melitus selama 1-4 tahun berjumlah 11 orang (36,7%), dan dengan diabetes melitus selama 5-8 tahun berjumlah 19 orang (63,3%). Uji parametrik T-Test memperlihatkan terdapat hubungan bermakna antara diabetes melitus yang lama dengan terjadinya disfungsi ereksi dengan nilai P = 0,025 dengan tingkat signifikansi 0,05. Simpulan: Diabetes melitus yang lama bisa mengakibatkan terjadinya disfungsi ereksi. Kata kunci: diabetes melitus, disfungsi ereksi.

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ORIGINAL RESEARCH—ENDOCRINOLOGY: The Effect of Diabetes Mellitus Treatment and Good Glycemic Control on the Erectile Function in Men with Diabetes Mellitus‐Induced Erectile Dysfunction: A Pilot Study

Journal of Sexual Medicine ◽

10.1111/j.1743-6109.2006.00221.x ◽

2006 ◽

Vol 3 (2) ◽

pp. 344-348 ◽

Cited By ~ 28

Author(s):

Onder Yaman ◽

Murat Akand ◽

Alptekin Gursoy ◽

Murat Faik Erdogan ◽

Kadri Anafarta

Keyword(s):

Diabetes Mellitus ◽

Erectile Dysfunction ◽

Pilot Study ◽

Glycemic Control ◽

Erectile Function ◽

Original Research ◽

Good Glycemic Control ◽

Diabetes Mellitus Treatment

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Efficacy of Tadalafil-SZ in the treatment of erectile dysfunction in patients with type 2 diabetes mellitus and with prediabetes

Urologicheskie vedomosti ◽

10.17816/uroved9333-38 ◽

2019 ◽

Vol 9 (3) ◽

pp. 33-38

Author(s):

Dmitriy G. Korenkov ◽

Dmitriy V. Tumanov ◽

Viktor A. Toropov

Keyword(s):

Quality Of Life ◽

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Erectile Dysfunction ◽

Erectile Function ◽

Waist Size ◽

Glycated Hemoglobin Level

The aim of the study was to evaluate the effectiveness of Tadalafil-SZ in treatment of erectile dysfunction in men suffering from type 2 diabetes mellitus or prediabetes. Two patient groups of thirty people with type 2 diabetes mellitus and prediabetes were identified. Patients mean age was 52.2 3.4 years and 48.5 2.8 years in groups with type 2 diabetes mellitus and prediabetes respectively. All patients suffered from erectile dysfunction, which significantly reduced their quality of life. To assess the erectile function, the ICEF (International Index of Erectile Function) and QoL (Quality of Life) questionnaires were used. Patients with prediabetes took Tadalafil-SZ 5 mg once a day for 3 months and patients with type 2 diabetes mellitus took Tadalafil-SZ 20 mg 2 times a week (Monday and Thursday) for 3 months as a treatment for erectile dysfunction. Results of this study showed that the administration of Tadalafil-SZ not only led to a significant improvement in the quality of life, a significant reduction in weight, body mass index, waist size in patients of both groups, but also led to a glycated hemoglobin level normalization without increasing the dose of glucose-lowering therapy in patients with uncomplicated type 2 diabetes mellitus and a pronounced decrease in morning insulin levels measured in the blood in patients with prediabetes. Almost half of patients in both groups increased testosterone blood level. According to the ICEF questionnaire, erectile function was significantly improved: in the group of patients with prediabetes: the ICEF-5 index prior to taking Tadalafil-SZ averaged 18.68 points (mild ED) whereas after taking the drug, a statistically significant increase in the ICEF index to an average of 23.02 points (p 0.05) was observed, which indicates the absence of erectile dysfunction in this group of patients during intake of Tadalafil-SZ. In the 2nd group of patients (with type 2 diabetes mellitus), the ICEF-5 index before treatment averaged 12.18 points, which reflects the average degree of erectile dysfunction, and at the end of the study there was a statistically significant increase in the ICEF-5 index to 18.44 points on average, which indicates a decrease in the severity of erectile dysfunction from moderate to mild (p 0.05). Overall Tadalafil-SZ is an effective treatment for erectile dysfunction in both patients with prediabetes and patients with type 2 diabetes mellitus.

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