scholarly journals Neuroinflammation evoked by brain injury in a rat model of lacunar infarct

2020 ◽  
pp. 113531
Author(s):  
Sylwia Dabrowska ◽  
Anna Andrzejewska ◽  
Hanna Kozlowska ◽  
Damian Strzemecki ◽  
Miroslaw Janowski ◽  
...  
Keyword(s):  
Brain Injury ◽  
Rat Model ◽  
Lacunar Infarct

scholarly journals Ulinastatin alleviates traumatic brain injury by reducing endothelin-1

2020 ◽  
Vol 12 (1) ◽  
pp. 001-008
Author(s):  
Ting Liu ◽  
Xing-Zhi Liao ◽  
Mai-Tao Zhou
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Western Blot ◽  
Water Content ◽  
Brain Edema ◽  
Rat Model ◽  
Neurosurgical Procedures ◽  
Brain Water Content ◽  
The Brain ◽  
Brain Water

Abstract Background Brain edema is one of the major causes of fatality and disability associated with injury and neurosurgical procedures. The goal of this study was to evaluate the effect of ulinastatin (UTI), a protease inhibitor, on astrocytes in a rat model of traumatic brain injury (TBI). Methodology A rat model of TBI was established. Animals were randomly divided into 2 groups – one group was treated with normal saline and the second group was treated with UTI (50,000 U/kg). The brain water content and permeability of the blood–brain barrier were assessed in the two groups along with a sham group (no TBI). Expression of the glial fibrillary acidic protein, endthelin-1 (ET-1), vascular endothelial growth factor (VEGF), and matrix metalloproteinase 9 (MMP-9) were measured by immunohistochemistry and western blot. Effect of UTI on ERK and PI3K/AKT signaling pathways was measured by western blot. Results UTI significantly decreased the brain water content and extravasation of the Evans blue dye. This attenuation was associated with decreased activation of the astrocytes and ET-1. UTI treatment decreased ERK and Akt activation and inhibited the expression of pro-inflammatory VEGF and MMP-9. Conclusion UTI can alleviate brain edema resulting from TBI by inhibiting astrocyte activation and ET-1 production.

Temporal profile and utility of serum neurofilament light in a rat model of mild traumatic brain injury

2021 ◽  
Vol 341 ◽  
pp. 113698
Author(s):  
William T. O'Brien ◽  
Louise Pham ◽  
Rhys D. Brady ◽  
Jesse Bain ◽  
Glenn R. Yamakawa ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Rat Model ◽  
Neurofilament Light ◽  
Temporal Profile

Ginsenoside Rg2 Ameliorates Brain Injury After Intracerebral Hemorrhage in a Rat Model of Preeclampsia

2021 ◽  
Author(s):  
Liying Cai ◽  
Feifei Hu ◽  
Wenwen Fu ◽  
Xiaofeng Yu ◽  
Weijie Zhong ◽  
...  
Keyword(s):  
Brain Injury ◽  
Intracerebral Hemorrhage ◽  
Rat Model

Treatment of early brain injury after subarachnoid hemorrhage in the rat model by inhibiting p53-induced ferroptosis

2021 ◽  
pp. 136134
Author(s):  
Hong Kuang ◽  
Tianhong Wang ◽  
Lei Liu ◽  
Chunhai Tang ◽  
Tao Li ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Rat Model ◽  
Early Brain Injury

Deletion of Mst1 attenuates neuronal loss and improves neurological impairment in a rat model of traumatic brain injury

2018 ◽  
Vol 1688 ◽  
pp. 15-21 ◽  
Author(s):  
Di Li ◽  
Haibo Ni ◽  
Qin Rui ◽  
Rong Gao ◽  
Gang Chen
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Rat Model ◽  
Neuronal Loss ◽  
Neurological Impairment

Delta opioid receptor agonist BW373U86 attenuates post-resuscitation brain injury in a rat model of asphyxial cardiac arrest

Resuscitation ◽  
2014 ◽  
Vol 85 (2) ◽  
pp. 299-305 ◽  
Author(s):  
Lu Yang ◽  
Xiaoyong Zhao ◽  
Meiyan Sun ◽  
Xude Sun ◽  
Linong Yao ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Brain Injury ◽  
Opioid Receptor ◽  
Rat Model ◽  
Receptor Agonist ◽  
Delta Opioid Receptor ◽  
Opioid Receptor Agonist ◽  
Asphyxial Cardiac Arrest

scholarly journals Protective effect of grifolin against brain injury in an acute cerebral ischemia rat model

2017 ◽  
Vol 16 (6) ◽  
pp. 1299 ◽  
Author(s):  
Shan Jing ◽  
Piaopiao Ying ◽  
Xiaohua Hu ◽  
Ze Yu ◽  
Jianwei Sun ◽  
...  
Keyword(s):  
Brain Injury ◽  
Cerebral Ischemia ◽  
Protective Effect ◽  
Rat Model ◽  
Acute Cerebral Ischemia

scholarly journals Recombinant human soluble thrombomodulin protects against brain injury in a CVST rat model, via downregulation of the HMGB1-RAGE axis

2016 ◽  
Vol 14 (6) ◽  
pp. 5217-5222 ◽  
Author(s):  
Jian-Jun Gu ◽  
Jie-Bin Chen ◽  
Jian-He Zhang ◽  
Hao Zhang ◽  
Shou-Sen Wang
Keyword(s):  
Brain Injury ◽  
Rat Model ◽  
Soluble Thrombomodulin ◽  
Recombinant Human Soluble Thrombomodulin

scholarly journals Blood-Based Brain and Global Biomarker Changes after Combined Hypoxemia and Hemorrhagic Shock in a Rat Model of Penetrating Ballistic-Like Brain Injury

2021 ◽  
Vol 2 (1) ◽  
pp. 370-380
Author(s):  
Xue Li ◽  
Kevin Pierre ◽  
Zhihui Yang ◽  
Lynn Nguyen ◽  
Gabrielle Johnson ◽  
...  
Keyword(s):  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Rat Model
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