ENDOMETRIAL PREPARATION FOR FROZEN EMBRYO TRANSFER AND IMPACT ON BIRTH WEIGHT: A SYSTEMATIC REVIEW AND META-ANALYSIS

Abstract BackgroundHypertensive disorders of pregnancy (HDP) is one of the most common pregnancy complications and causes of maternal morbidity and mortality. Many cohort studies were conducted to study adverse pregnancy outcomes associated with pregnancies from assisted reproductive technology. We aimed to comprehensively review all available evidence to date to compare the odds of HDP and preeclampsia between pregnancies achieved by in vitro fertilization (IVF) and spontaneous pregnancies.MethodsWe conducted a systematic review and meta-analysis based on cohort studies identified from EMBASE, MEDLINE, and Cochrane Library (up to 2020) and manually using a structured search strategy. Cohort studies that compared pregnancies after IVF with or without intracytoplasmic sperm fertilization (ICSI) and SC with HDP or preeclampsia as the outcome of interest were included. The control group was women who conceived spontaneously without ART or fertility medications. Studies published in English, French, Chinese, and Portuguese were reviewed. Eligibility and quality of studies were evaluated by two reviewers independently. Quality assessment was conducted using the Newcastle Ottawa Scale (NOS) for Cohort Studies. The pooled results were reported in odds ratios (OR) with 95% confidence intervals based on random effects models. I-squared (I2) test was used to evaluate heterogeneity and publication bias was assessed using funnel plots.ResultsSeventy-eight studies were included after a screening of 1,879 abstracts and 275 full text articles. Compared to SC, IVF/ICSI singleton pregnancies (OR 1.63; 95% CI 1.54-1.74; I2 = 79%) and multiple pregnancies (OR 1.31; 95% CI 1.18-1.47; I2 = 73%) were both associated with higher odds of HDP. Singleton pregnancies with oocyte donation had the highest odds of HDP out of all groups analyzed (OR 4.11; 95% CI 2.75-6.16; I2 = 85%). Frozen embryo transfer resulted in higher odds of HDP (OR 1.74; 95% CI 1.58-1.92; I2 = 55%) than fresh embryo transfer (OR 1.43; 95% CI 1.33-1.53; I2 = 72%). Similar findings for preeclampsia were also reported.ConclusionsOur meta-analysis confirmed that IVF/ICSI pregnancies are at high odds of HDP and preeclampsia than SC, irrespective of the plurality. The odds were especially high in frozen embryo transfer and oocyte donation pregnancies.

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Neonatal outcomes in singleton pregnancies conceived by fresh or frozen embryo transfer compared to spontaneous conceptions: a systematic review and meta-analysis

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-020-05593-4 ◽

2020 ◽

Vol 302 (1) ◽

pp. 31-45 ◽

Cited By ~ 3

Author(s):

Flavia T. S. Elias ◽

Danielle Weber-Adrian ◽

Jessica Pudwell ◽

Jillian Carter ◽

Mark Walker ◽

...

Keyword(s):

Systematic Review ◽

Embryo Transfer ◽

Meta Analysis ◽

Frozen Embryo Transfer ◽

Neonatal Outcomes ◽

Singleton Pregnancies

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OBSTETRIC AND PERINATAL OUTCOMES IN SINGLETON PREGNANCIES RESULTING FROM MEDICATED VERSUS NATURAL CYCLE FROZEN EMBRYO TRANSFER: A SYSTEMATIC REVIEW AND META-ANALYSIS

Fertility and Sterility ◽

10.1016/j.fertnstert.2021.07.452 ◽

2021 ◽

Vol 116 (3) ◽

pp. e163-e164

Author(s):

Freya Baird ◽

Emilia Smith ◽

Yusuf Beebeejaun ◽

Mahua Bhaduri ◽

Venkatesh Subramanian ◽

...

Keyword(s):

Systematic Review ◽

Embryo Transfer ◽

Meta Analysis ◽

Perinatal Outcomes ◽

Frozen Embryo Transfer ◽

Natural Cycle ◽

Singleton Pregnancies

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Fresh versus elective frozen embryo transfer in IVF/ICSI cycles: a systematic review and meta-analysis of reproductive outcomes

Human Reproduction Update ◽

10.1093/humupd/dmy033 ◽

2018 ◽

Vol 25 (1) ◽

pp. 2-14 ◽

Cited By ~ 83

Author(s):

Matheus Roque ◽

Thor Haahr ◽

Selmo Geber ◽

Sandro C Esteves ◽

Peter Humaidan

Keyword(s):

Systematic Review ◽

Embryo Transfer ◽

Meta Analysis ◽

Frozen Embryo Transfer ◽

Reproductive Outcomes

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The Developmental Stage at Cryopreservation in Assisted Reproduction: A Systematic Review and Meta-Analysis of Pregnancy Outcomes

International Journal of Women’s Health Care ◽

10.33140/ijwhc.06.01.07 ◽

2021 ◽

Vol 6 (1) ◽

Keyword(s):

Systematic Review ◽

Pregnancy Rate ◽

Embryo Transfer ◽

Live Birth ◽

Pregnancy Outcomes ◽

Birth Rate ◽

Developmental Stages ◽

Meta Analysis ◽

Live Birth Rate ◽

Frozen Embryo Transfer

To date, there is no consensus in embryo developmental stages for cryopreservation. The present study aimed to investigate the impact of embryo developmental stages at cryopreservation on pregnancy outcomes of frozen embryo transfer. Systematic review and meta-analysis of relevant studies identified through MEDLINE literature search was performed. The primary outcome was live birth/delivery rate, and the secondary outcomes included implantation rate, ongoing pregnancy rate, clinical pregnancy rate, miscarriage rate, and multiple pregnancy rate. The protocol of this systematic review has been registered on PROSPERO 2017 (registration number: CRD42017072828). Five studies met the eligibility criteria were included in the present review. The outcomes of embryos frozen at different stages but transferred at the same stage were analyzed and compared. Embryos frozen at non-blastocyst showed a significant higher delivery/live birth rate than those cryopreserved at blastocyst (odds ratio=1.37; 95% confidence interval, 1.13-1.66) in the setting of frozen embryo transfer with blastocysts. There was only a limited number of studies with analyzable data for comparisons. The literature varied substantially in study design and methodology applied. Although a significant difference was observed toward an improved delivery/live birth rate for blastocyst transfer with embryos frozen at non-blastocyst stage, future studies are required to further corroborate this finding.

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Association between abnormal body mass index and pregnancy outcomes in patients following frozen embryo transfer: a systematic review and meta-analysis

Reproductive Biology and Endocrinology ◽

10.1186/s12958-021-00809-x ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Jiaqi Yang ◽

Yichen He ◽

Yiqing Wu ◽

Dan Zhang ◽

Hefeng Huang

Keyword(s):

Systematic Review ◽

Body Mass Index ◽

Embryo Transfer ◽

Body Mass ◽

Subgroup Analysis ◽

Pregnancy Outcomes ◽

Meta Analysis ◽

Frozen Embryo Transfer ◽

Low Bmi ◽

High Bmi

Abstract Background There has been increasing interest in the relationship between body mass index(BMI) and pregnancy outcomes, especially in women undergoing frozen embryo transfer(FET). Several observational studies have been published, but so far with conflicting results. Methods A systematic review and meta-analysis was conducted according to PRISMA guidelines. Pubmed, Embase, Cochrane Library, Clinicaltrails.gov and Web of Science databases were searched based on established search strategy from inception through January 2021. Results Twelve studies were eligible. In women following FET, high BMI (BMI ≥ 23 kg/m2) was associated with an impaired live birth rate (LBR, OR: 0.89, 95% CI: 0.82–0.96, P = 0.002), but wasn’t associated with the implantation rate or the clinical pregnancy rate. Subgroup analysis revealed higher LBR for women didn’t complicated by polycystic ovary syndrome (PCOS, OR: 0.96, 95% CI: 0.85–1.08, P = 0.46) and women with blastocyst transferred (OR: 0.89, 95% CI: 0.68–1.16, P = 0.40). LBR did not differ between the low BMI group (BMI < 18.5 kg/m2) and the normal weight group. Conclusions Our study showed that high BMI in women is negatively associated with LBR in FET cycles, whereas low BMI isn’t. The results of subgroup analysis implied a need for women with a high BMI to get individualized weight management and treatment. Further evidence is still required to optimize preconception health and develop Nutritional and exercise guidelines.

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