Structure determination, bitterness evaluation and hepatic gluconeogenesis inhibitory activity of triterpenoids from the Momordica charantia fruit

2022 ◽  
Vol 372 ◽  
pp. 131224
Author(s):  
Yuanyuan Deng ◽  
Yongxuan Ma ◽  
Huijuan Liu ◽  
Yan Zhang ◽  
Zhencheng Wei ◽  
...  
2011 ◽  
Vol 19 (17) ◽  
pp. 5085-5092 ◽  
Author(s):  
Xiang Wan ◽  
Xiao-Bing Wang ◽  
Ming-Hua Yang ◽  
Jun-Song Wang ◽  
Ling-Yi Kong

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
N Kúsz ◽  
D Rédei ◽  
P Orvos ◽  
L Tálosi ◽  
G Jakab ◽  
...  

Foods ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 434 ◽  
Author(s):  
Michaelle Chokki ◽  
Mihaela Cudălbeanu ◽  
Cheikna Zongo ◽  
Durand Dah-Nouvlessounon ◽  
Ioana Otilia Ghinea ◽  
...  

Background: Momordica charantia Linn. (Cucurbitaceae), the wild variety of bitter melon and Morinda lucida Benth (Rubiaceae) were commonly used as a popular folk medicine in Benin. This research focused to measure the antioxidant and enzyme inhibitory effects of M. charantia and M. lucida leaves and their antidiabetic activity. Methods: Antioxidant activities were evaluated by micro-dilution technique using DPPH free radical scavenging activity and β-carotene-linoleate bleaching assay. The α-amylase inhibition assay was carried out utilizing the 3,5-dinitrosalicylic acid procedure, while β-glucosidase inhibition assay was demonstrated using as substrate p-nitrophenyl-β-D-glucopyranoside (PNPG). HPLC-DAD analysis was realized using a high-performance liquid chromatography systems with diode-array detector, L-3000. Results: Chlorogenic acid, epicatechin, daidzein, rutin, naringin, quercetin, naringenin and genistein were identified as polyphenol compounds in the both plants extract. Dichloromethane and ethyl acetate extracts showed a good α-amylase inhibitory activity (56.46 ± 1.96% and 58.76 ± 2.74% respectively). M. lucida methanolic extract has shown IC50 of 0.51 ± 0.01 mg/mL, which is the lowest for DPPH scavenging activity. M. lucida dichloromethane extract showed the highest inhibitory capacity of β-glucosidase activity (82.11. ± 2.15%). Conclusion: These results justify some traditional medicinal uses of both plants. The purified fractions could be used in future formulations, possibly incorporated in functional foods to combat certain diseases.


Sign in / Sign up

Export Citation Format

Share Document