Identification and characterization of interferon regulatory factor 1 from Lateolabrax japonicus involved in antiviral immune response against grouper nervous necrosis virus infection

2020 ◽  
Vol 97 ◽  
pp. 403-410 ◽  
Author(s):  
Zhenhua Ma ◽  
Xu Chen ◽  
Rui Yang ◽  
Jing Hu ◽  
Shengjie Zhou ◽  
...  
Keyword(s):  
Immune Response ◽  
Interferon Regulatory Factor ◽  
Nervous Necrosis Virus ◽  
Regulatory Factor ◽  
Necrosis Virus ◽  
Lateolabrax Japonicus ◽  
Antiviral Immune Response ◽  
Interferon Regulatory Factor 1 ◽  
Identification And Characterization

The Pivotal Role of Signal Regulatory Protein α in Exacerbating Pulmonary Fibrosis Complicated with Bacterial Infection

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yamaguchi R ◽  
◽  
Sakamoto A ◽  
Haraguchi M ◽  
Narahara S ◽  
...  
Keyword(s):  
Immune Response ◽  
Pulmonary Fibrosis ◽  
Bacterial Infection ◽  
Signaling Pathway ◽  
Regulatory Protein ◽  
Interferon Regulatory Factor ◽  
Regulatory Factor ◽  
Interferon Regulatory Factor 1 ◽  
Th1 Immune Response

The pathogenesis of pulmonary fibrosis remains unknown. However, bacterial infections in patients with idiopathic pulmonary fibrosis are a serious complication that exacerbate the disease. Serum levels of Surfactant Protein D (SPD) are known to be elevated in patients with pulmonary fibrosis, but the role of SPD in pulmonary fibrosis complicated with bacterial infection is unknown. Lipopolysaccharide upregulates Interleukin (IL)-12p40 expression and IL-12p40 promotes Interferon Gamma (IFNγ) production to induce the T helper cell 1 (Th1) immune response via Signal Transducers and Activators of Transcription 4 (STAT4) signaling. A lack of IFNγ shifts the immune response from Th1 to Th2. IL-4 is a profibrotic Th2 cytokine that activates fibroblasts. Granulocyte-macrophage colony-stimulating factor induced by IL-1 and TNFα during the Th1 immune response upregulates Signal Regulatory Protein α (SIRPα) expression. Interferon Regulatory Factor 1 (IRF1) functions as the promoter activator of IL-12p40 after stimulation with LPS. SPD is a ligand for SIRPα, and SPD/SIRPα ligation activates the Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Related Kinase (ERK) signal cascade; ERK downregulates Interferon Regulatory Factor 1 (IRF1) expression. Consequently, the SPD/SIRPα signaling pathway decreases IL-12p40 production in human macrophages after exposure to LPS. IL-12p40 is a key immunoregulatory factor in bacterial infection that promotes production of IFNγ by T lymphocytes. Pulmonary fibroblasts are activated by IL-4/IL-4R ligation. IFNγ induces IRF1 via STAT1 signaling, and IRF1 acts as the promoter repressor of IL-4 to attenuate its production. IFNγ also inhibits IL-4R expression. A reduction in IFNγ induced by IL-12p40 deficiency via the SPD/SIRPα signaling pathway enhances IL-4 and IL-4R expression to augment the activity of fibroblasts. This finding indicates that pulmonary fibrosis is exacerbated by SPD/SIRPα signaling during bacterial infection.

scholarly journals Interferon regulatory factor 1 priming of tumour-derived exosomes enhances the antitumour immune response

2017 ◽  
Vol 118 (1) ◽  
pp. 62-71 ◽  
Author(s):  
Mu-qing Yang ◽  
Qiang Du ◽  
Patrick R Varley ◽  
Julie Goswami ◽  
Zhihai Liang ◽  
...  
Keyword(s):  
Immune Response ◽  
Interferon Regulatory Factor ◽  
Regulatory Factor ◽  
Interferon Regulatory Factor 1

Interferon regulatory factor-1 is necessary for a T helper 1 immune response in vivo

1997 ◽  
Vol 56 ◽  
pp. 84
Author(s):  
M. Lohoff ◽  
D. Ferrick ◽  
H.-W. Mitrücker ◽  
G.S. Duncan ◽  
G.S. Duncan ◽  
...  
Keyword(s):  
Immune Response ◽  
Interferon Regulatory Factor ◽  
T Helper ◽  
Regulatory Factor ◽  
T Helper 1 ◽  
Interferon Regulatory Factor 1
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