Expression of Th17 axis as a biomarker panel in diagnosis and prognosis of colorectal cancer

Gene Reports ◽  
2021 ◽  
pp. 101363
Author(s):  
Mandana Kazemi ◽  
Maryam Peymani
Keyword(s):  
Colorectal Cancer ◽  
Biomarker Panel ◽  
Diagnosis And Prognosis

scholarly journals Circulating Biomarkers of Colorectal Cancer (CRC)—Their Utility in Diagnosis and Prognosis

2021 ◽  
Vol 10 (11) ◽  
pp. 2391
Author(s):  
Marta Łukaszewicz-Zając ◽  
Barbara Mroczko
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Mediators ◽  
Colorectal Adenomas ◽  
Global Burden ◽  
Circulating Biomarkers ◽  
Specific Nature ◽  
Diagnosis And Prognosis ◽  
Specific Proteins ◽  
Novel Biomarkers ◽  
Number Of Publications

The global burden of colorectal cancer (CRC) is expected to increase, with 2.2 million new cases and 1.1 million annual deaths by 2030. Therefore, the establishment of novel biomarkers useful in the early diagnosis of CRC is of utmost importance. A number of publications have documented the significance of the overexpression of several specific proteins, such as inflammatory mediators, in CRC progression. However, little is known about the potential utility of these proteins as circulating blood tumor biomarkers of CRC. Therefore, in the present review we report the results of our previous original studies as well as the findings of other authors who investigated whether inflammatory mediators might be used as novel biomarkers in the diagnosis and prognosis of CRC. Our study revealed that among all of the tested proteins, serum M-CSF, CXCL-8, IL-6 and TIMP-1 have the greatest value in the diagnosis and progression of CRC. Serum TIMP-1 is useful in differentiating between CRC and colorectal adenomas, whereas M-CSF and CRP are independent prognostic factors for the survival of patients with CRC. This review confirms the promising significance of these proteins as circulating biomarkers for CRC. However, due to their non-specific nature, further validation of their sensitivity and specificity is required.

407 A novel biomarker panel for prediction of recurrence in early stage colorectal cancer among orientals

2015 ◽  
Vol 51 ◽  
pp. S81
Author(s):  
T.H. Wang ◽  
P.C. Lin ◽  
Y.P. Lee ◽  
B.W. Lin ◽  
P.F. Kuo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Stage ◽  
Biomarker Panel

scholarly journals Blood-Based Protein Biomarker Panel for the Detection of Colorectal Cancer

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0120425 ◽  
Author(s):  
Kim Y. C. Fung ◽  
Bruce Tabor ◽  
Michael J. Buckley ◽  
Ilka K. Priebe ◽  
Leanne Purins ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Protein Biomarker ◽  
Biomarker Panel

scholarly journals Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas

2011 ◽  
Vol 10 (1) ◽  
pp. 85 ◽  
Author(s):  
Guro E Lind ◽  
Stine A Danielsen ◽  
Terje Ahlquist ◽  
Marianne A Merok ◽  
Kim Andresen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Sensitivity And Specificity ◽  
High Sensitivity ◽  
Biomarker Panel ◽  
Epigenetic Biomarker

scholarly journals Chemokines—What Is Their Role in Colorectal Cancer?

2020 ◽  
Vol 27 (1) ◽  
pp. 107327482090338 ◽  
Author(s):  
Sara Pączek ◽  
Marta Łukaszewicz-Zając ◽  
Barbara Mroczko
Keyword(s):  
Colorectal Cancer ◽  
Current Knowledge ◽  
Early Stage ◽  
Distant Metastases ◽  
Cell Types ◽  
Diagnosis And Prognosis ◽  
Novel Biomarkers ◽  
Specific Receptors ◽  
Common Malignancy

Colorectal cancer (CRC) is one of the leading causes of cancer-related death. It is the second most frequently diagnosed malignancy in Europe and third worldwide. Colorectal malignancies diagnosed at an early stage offer a promising survival rate. However, advanced tumors often present distant metastases even after the complete resection of a primary tumor. Therefore, novel biomarkers of CRC are sorely needed in the diagnosis and prognosis of this common malignancy. A family of chemokines are composed of small, secreted proteins. They are best known for their ability to stimulate the migration of several cell types. Some investigations have indicated that chemokines are involved in cancer development, including CRC. This article presents current knowledge regarding chemokines and their specific receptors in CRC progression. Moreover, the prime aim of this review is to summarize the potential role of these proteins as biomarkers in the diagnosis and prognosis of CRC.

scholarly journals Urinary Metabolomics to Identify a Unique Biomarker Panel for Detecting Colorectal Cancer: A Multicenter Study

2019 ◽  
Vol 28 (8) ◽  
pp. 1283-1291 ◽  
Author(s):  
Lu Deng ◽  
Kathleen Ismond ◽  
Zhengjun Liu ◽  
Jeremy Constable ◽  
Haili Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Multicenter Study ◽  
Biomarker Panel

scholarly journals Integrated Analysis Identifies a Nine-microRNA Signature Biomarker for Diagnosis and Prognosis in Colorectal Cancer

2020 ◽  
Vol 11 ◽  
Author(s):  
Ziyang Di ◽  
Maojun Di ◽  
Weihua Fu ◽  
Qiang Tang ◽  
Yanwei Liu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Integrated Analysis ◽  
Diagnosis And Prognosis

scholarly journals Emerging microRNA biomarkers for colorectal cancer diagnosis and prognosis

Open Biology ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 180212 ◽  
Author(s):  
Bing Chen ◽  
Zijing Xia ◽  
Ya-Nan Deng ◽  
Yanfang Yang ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Target Genes ◽  
Research Use ◽  
Biological Processes ◽  
Functional Roles ◽  
Analytical Technique ◽  
Diagnosis And Prognosis ◽  
Recurrence Prediction ◽  
Extracellular Mirnas ◽  
Non Coding Rnas

MicroRNAs (miRNAs) are one abundant class of small, endogenous non-coding RNAs, which regulate various biological processes by inhibiting expression of target genes. miRNAs have important functional roles in carcinogenesis and development of colorectal cancer (CRC), and emerging evidence has indicated the feasibility of miRNAs as robust cancer biomarkers. This review summarizes the progress in miRNA-related research, including study of its oncogene or tumour-suppressor roles and the advantages of miRNA biomarkers for CRC diagnosis, treatment and recurrence prediction. Along with analytical technique improvements in miRNA research, use of the emerging extracellular miRNAs is feasible for CRC diagnosis and prognosis.

scholarly journals Investigation of miRNA Biology by Bioinformatic Tools and Impact of miRNAs in Colorectal Cancer—Regulatory Relationship of c-Myc and p53 with miRNAs

2007 ◽  
Vol 3 ◽  
pp. 117693510700300 ◽  
Author(s):  
Yaguang Xi ◽  
John R. Edwards ◽  
Jingfang Ju
Keyword(s):  
Colorectal Cancer ◽  
Tumor Suppressor ◽  
Suppressor Gene ◽  
Regulatory Relationship ◽  
Bioinformatic Tools ◽  
Diagnosis And Prognosis ◽  
Mrna Targets ◽  
Mirnas Expression ◽  
Mirna Expression Profiling ◽  
Relationship Of

MicroRNAs (miRNAs) are a class of small non-coding RNAs that mediate gene expression at the post-transcriptional and translational levels and have been demonstrated to be involved in diverse biological functions. Mounting evidence in recent years has shown that miRNAs play key roles in tumorigenesis due to abnormal expression of and mutations in miRNAs. High throughput miRNA expression profiling of several major tumor types has identified miRNAs associated with clinical diagnosis and prognosis of cancer treatment. Previously our group has discovered a novel regulatory relationship between tumor suppressor gene p53 with miRNAs expression and a number of miRNA promoters contain putative p53 binding sites. In addition, others have reported that c-myc can mediate a large number of miRNAs expression. In this review, we will emphasize algorithms to identify mRNA targets of miRNAs and the roles of miRNAs in colorectal cancer. In particular, we will discuss a novel regulatory relationship of miRNAs with tumor suppressor p53 and c-myc. miRNAs are becoming promising novel targets and biomarkers for future cancer therapeutic development and clinical molecular diagnosis.

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