scholarly journals B-PO02-137 OPEN-SOURCE PLATFORM FOR ANALYSIS OF FIBROSIS BEFORE AND AFTER A PULMONARY VEIN ISOLATION PROCEDURE

Heart Rhythm ◽  
2021 ◽  
Vol 18 (8) ◽  
pp. S153
Author(s):  
Jose Alonso Solis-Lemus ◽  
Caroline H. Roney ◽  
Orod Razeghi ◽  
Iain Sim ◽  
Irum Kotadia ◽  
...  
EP Europace ◽  
2021 ◽  
Vol 23 (Supplement_3) ◽  
Author(s):  
P Loh ◽  
MHA Groen ◽  
K Taha ◽  
FHM Wittkampf ◽  
PA Doevendans ◽  
...  

Abstract Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): Abbott Background Irreversible electroporation (IRE) is a promising new non-thermal ablation technology for pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF). First in human studies demonstrated the feasibility and safety of IRE PVI. Objective Further investigate the safety of IRE PVI. Methods Twenty patients with symptomatic AF underwent IRE PVI under conscious sedation. Oral anticoagulation was uninterrupted and heparin was administered to maintain activated clotting time at 300-350 seconds. Non-arcing, non-barotraumatic 6 ms, 200 J IRE applications were delivered via a custom non-steerable 8 F, 14-polar circular IRE ablation catheter with a variable hoop diameter (16-27 mm). Voltage mapping  of the left atrium and the PVs was performed before and after ablation with a conventional circular mapping catheter. For both catheters a single transseptal access (8 F introducer, Agilis NxTTM) was used. Adenosine testing was performed after a 30-minute waiting period. On day 1 after ablation, patients underwent esophagoscopy and brain MRI (DWI/FLAIR). If abnormalities were detected, examinations were repeated in due time. Results In 20 patients, all 80 PVs could be successfully isolated with a mean of 11,8 ± 1,4 IRE applications per patient. Average time from first to last IRE application was 22 ± 5 minutes, total procedure duration was 107 ± 13 minutes and total fluoroscopy time was 23 ± 5 minutes. One PV reconnection occurred during adenosine testing, re-isolation was achieved with 2 additional IRE pulses. No periprocedural complications were observed. Brain MRI on day 1 after ablation showed punctate asymptomatic lesions in 3/20 patients (15%). At follow-up MRI the lesion disappeared in 1 patient while in the other 2 patients 1 lesion persisted. Esophagoscopy on day 1 showed an asymptomatic esophageal lesion in 1/20 patients (5%), at repeat esophagoscopy on day 22 the lesion had resolved completely. Conclusion Acute electrical PV isolation could be achieved safely and rapidly by IRE ablation under conscious sedation in 20 patients with symptomatic AF. Acute silent cerebral lesions were detected in 3/20 patients (15%) and may be due to ablation or to changes of therapeutic and diagnostic catheters over a single transseptal access.


EP Europace ◽  
2017 ◽  
Vol 19 (suppl_3) ◽  
pp. iii283-iii283
Author(s):  
S. Bordignon ◽  
L. Perrotta ◽  
F. Bologna ◽  
A. Konstantinou ◽  
FK. Weise ◽  
...  

EP Europace ◽  
2018 ◽  
Vol 20 (suppl_1) ◽  
pp. i54-i55
Author(s):  
T Neumann ◽  
H Greiss ◽  
S Zaltsberg ◽  
K Weipert ◽  
A Hain ◽  
...  

2006 ◽  
Vol 22 (2) ◽  
pp. 98-102
Author(s):  
Keiichi Inada ◽  
Teiichi Yamane ◽  
Yasuko Kanzaki ◽  
Seiichiro Matsuo ◽  
Kenri Shibayama ◽  
...  

2017 ◽  
Vol 59 (4) ◽  
pp. 321-328
Author(s):  
A. Revilla Orodea ◽  
I. Sánchez Lite ◽  
J.C. Gallego Beuth ◽  
T. Sevilla Ruiz ◽  
M.G. Sandín Fuentes ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document