Natural history of left ventricular hypertrophy in infants of diabetic mothers

2021 ◽  
Author(s):  
Emanuele Monda ◽  
Federica Verrillo ◽  
Ippolita Altobelli ◽  
Michele Lioncino ◽  
Martina Caiazza ◽  
...  
Keyword(s):  
Natural History ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Infants Of Diabetic Mothers ◽  
History Of ◽  
Diabetic Mothers

Genotype–phenotype analysis and natural history of left ventricular hypertrophy in LEOPARD syndrome

2008 ◽  
Vol 146A (5) ◽  
pp. 620-628 ◽  
Author(s):  
Giuseppe Limongelli ◽  
Anna Sarkozy ◽  
Giuseppe Pacileo ◽  
Paolo Calabrò ◽  
Maria Cristina Digilio ◽  
...  
Keyword(s):  
Natural History ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Leopard Syndrome ◽  
Phenotype Analysis ◽  
History Of

scholarly journals 585 Natural history of left ventricular hypertrophy in infants of diabetic mothers

2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Emanuele Monda ◽  
Federica Verrillo ◽  
Michele Lioncino ◽  
Ippolita Altobelli ◽  
Martina Caiazza ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Wall Thickness ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
P Value ◽  
Z Score ◽  
Benign Condition ◽  
Infants Of Diabetic Mothers ◽  
Diabetic Mothers

Abstract Aims This study sought to describe the characteristics and the natural course of left ventricular hypertrophy (LVH) in a well-characterized consecutive cohort of infants of diabetic mothers (IDMs). Methods and results Sixty consecutive IDMs with LVH have been retrospectively identified and enrolled in the study. All IDMs were evaluated at baseline and every 6 months until LV wall thickness regression, defined as the decrease of wall thickness measurement into the normal reference range for cardiac parameters (z-score > −2 and <2). A comprehensive assessment was performed in those patients with diagnostic markers suggestive of a different cause and/or without significant reduction of the LVH during follow-up. At 1-year follow-up, all IDMs showed a significant reduction of maximal wall thickness MWT [6.00 mm (IQR: 5.00–712) vs. 5.50 mm (IQR: 5.00–6.00), P-value <0.001; MWT-z-score: 4.86 (IQR: 3.93–7.61) vs. 1.72 (IQR: 1.08–2.85), P-value <0.001] compared to baseline, and all patients showed LV wall thickness regression or residual mild or moderate LVH (57%, 28%, and 12%, respectively), except two patients with persistent severe LVH, that after a comprehensive clinical-genetic assessment were diagnosed as Noonan syndrome with multiple lentigines. At multivariate analysis, MWT was negatively associated with LV wall thickness regression at 1-year follow-up [MWT-mm: OR: 0.48 (0.29–0.79), P-value = 0.004; MWT-z-score: OR: 0.71 (0.56–0.90), P-value = 0.004]. Conclusions LVH in IDMs represents a benign condition with complete regression during the first years of life. In those patients without LV wall thickness regression, combined with clinical markers suggesting a specific disease, a complete work-up is required for a definite diagnosis.

scholarly journals Natural history of left ventricular hypertrophy in infants of diabetic mothers

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
E Monda ◽  
F Verrillo ◽  
I Altobelli ◽  
M Lioncino ◽  
M Caiazza ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Wall Thickness ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
P Value ◽  
Z Score ◽  
Benign Condition ◽  
Infants Of Diabetic Mothers ◽  
Diabetic Mothers

Abstract Background Left ventricular hypertrophy (LVH) in infants of diabetic mothers (IDMs) has been generally considered a benign condition, which usually regresses as the stimulus for the insulin production disappears, resulting in normalized left ventricular wall thickness in the 6 months of life. However, these conclusions have been based on small, mostly outdated cohort studies. Indeed, it has been recently shown that increased left ventricular mass persists in late infancy (6 to 12 months), long after the intrauterine exposure has been removed, suggesting that other factors may potentially contribute. Purpose This study sought to describe the characteristics and the natural course of LVH in a well-characterized consecutive cohort of IDMs. Methods Sixty consecutive IDMs with LVH have been retrospectively identified and enrolled in the study. All IDMs were evaluated at baseline and every 6 months until LV wall thickness regression, defined as the decrease of wall thickness measurement into the normal reference range for cardiac parameters (z-score >−2 and <2). A comprehensive assessment was performed in those patients with diagnostic markers suggestive of a different cause and/or without significant reduction of the LVH during follow-up. Results At 1-year follow-up, all IDMs showed a significant reduction of maximal wall thickness (MWT) (MWT-mm: 6.67±2.37 vs. 5.83±1.70, p-value<0.001; MWT-z-score: 6.67±4.71 vs. 2.39±2.55, p-value<0.001) and left ventricular outflow tract (LVOT) gradient (15.35±15.58 vs. 11.22±8.14, p-value<0.004), compared to baseline, and all patients showed LV wall thickness regression or residual mild or moderate LVH (57%, 28%, and 12%, respectively) (Figure 1), except 2 patients with persistent severe LVH, that after a comprehensive clinical-genetic assessment were diagnosed as Noonan syndrome with multiple lentigines. At multivariate analysis, MWT was significantly associated with LV wall thickness regression at 1-year follow-up (MWT-mm: OR 0.48 [0.29–0.79], p-value=0.004; MWT-z-score: OR 0.71 [0.56–0.90], p-value=0.004) in an inversely proportional fashion. Overall, 59%, 72% and 79% of IDMs with LVH showed a complete LV wall thickness regression at 1-year, 2-year and 3-year follow-up, respectively (Figure 2). Excluding the two patients with a different cause of LVH, all IDMs showed a LV wall thickness regression in the first 6 years of life. Conclusions LVH in IDMs represents a benign condition with complete regression during the first years of life. In those patients without LV wall thickness regression, combined with clinical markers suggesting a specific disease, a complete work-up is required for a definite diagnosis. FUNDunding Acknowledgement Type of funding sources: None. Figure 1 Figure 2

The natural history of hypertrophic cardiomyopathy in infants of diabetic mothers

1979 ◽  
Vol 95 (6) ◽  
pp. 1020-1025 ◽  
Author(s):  
Gerald L. Way ◽  
Robert R. Wolfe ◽  
E. Eshaghpour ◽  
Robert L. Bender ◽  
Richard B. Jaffe ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Natural History ◽  
Infants Of Diabetic Mothers ◽  
History Of ◽  
Diabetic Mothers

scholarly journals Persistent Aortic Stiffness and Left Ventricular Hypertrophy in Children of Diabetic Mothers.

CJC Open ◽  
2020 ◽  
Author(s):  
Victor Do ◽  
Luke Eckersley ◽  
Lily Lin ◽  
Sandra T. Davidge ◽  
Michael K. Stickland ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Aortic Stiffness ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Diabetic Mothers
Sign in / Sign up

Export Citation Format

Share Document