Thermosensitive liposomes encapsulating hypericin: Characterization and photodynamic efficiency

2021 ◽  
pp. 121195
Author(s):  
Alice Abu Dayyih ◽  
Mohamad Alawak ◽  
Abdallah M. Ayoub ◽  
Muhammad U. Amin ◽  
Wael Abu Dayyih ◽  
...  
Keyword(s):  
Thermosensitive Liposomes

scholarly journals Untargeted large volume hyperthermia reduces tumor drug uptake from thermosensitive liposomes

2021 ◽  
pp. 1-1
Author(s):  
Krishna K. Ramajayam ◽  
A. Marissa Wolfe ◽  
Anjan Motamarry ◽  
Georges Nahhas ◽  
John Yost ◽  
...  
Keyword(s):  
Large Volume ◽  
Drug Uptake ◽  
Thermosensitive Liposomes

Targeted thermosensitive liposomes: an attractive novel approach for increased drug delivery to solid tumors

2013 ◽  
Vol 11 (1) ◽  
pp. 83-100 ◽  
Author(s):  
Bilyana M Dicheva ◽  
Gerben A Koning
Keyword(s):  
Drug Delivery ◽  
Solid Tumors ◽  
Novel Approach ◽  
Thermosensitive Liposomes

scholarly journals Current developments in drug delivery with thermosensitive liposomes

2019 ◽  
Vol 14 (4) ◽  
pp. 365-379 ◽  
Author(s):  
Hongshu Bi ◽  
Jianxiu Xue ◽  
Hong Jiang ◽  
Shan Gao ◽  
Dongjuan Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Thermosensitive Liposomes

Thermosensitive nanoplatforms for photothermal release of cargo from liposomes under intracellular temperature monitoring

RSC Advances ◽  
2015 ◽  
Vol 5 (113) ◽  
pp. 93530-93538 ◽  
Author(s):  
Satoshi Arai ◽  
Chi-Lik Ken Lee ◽  
Young-Tae Chang ◽  
Hirotaka Sato ◽  
Keitaro Sou
Keyword(s):  
Near Infrared ◽  
Infrared Laser ◽  
Temperature Monitoring ◽  
Thermosensitive Liposomes

Cargo release from thermosensitive liposomes by a near infrared laser was investigated under intracellular temperature monitoring.

scholarly journals In Vivo Assessment of Thermosensitive Liposomes for the Treatment of Port Wine Stains by Antifibrinolytic Site-Specific Pharmaco-Laser Therapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 591
Author(s):  
Mingjuan Li ◽  
M. Ingmar van Raath ◽  
Shervin Khakpour ◽  
Ahmet Seçilir ◽  
Bart C. Sliggers ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Experimental Treatment ◽  
Port Wine ◽  
Site Specific ◽  
Port Wine Stains ◽  
Antifibrinolytic Drugs ◽  
Thermosensitive Liposomes ◽  
Local Release

Antifibrinolytic site-specific pharmaco-laser therapy (SSPLT) is an experimental treatment modality for refractory port wine stains (PWS). Conceptually, antifibrinolytic drugs encapsulated in thermosensitive liposomes are delivered to thrombi that form in semi-photocoagulated PWS blood vessels after conventional laser treatment. Local release of antifibrinolytics is induced by mild hyperthermia, resulting in hyperthrombosis and complete occlusion of the target blood vessel (clinical endpoint). In this study, 20 thermosensitive liposomal formulations containing tranexamic acid (TA) were assayed for physicochemical properties, TA:lipid ratio, encapsulation efficiency, and endovesicular TA concentration. Two candidate formulations (DPPC:DSPE-PEG, DPPC:MPPC:DSPE-PEG) were selected based on optimal properties and analyzed for heat-induced TA release at body temperature (T), phase transition temperature (Tm), and at T > Tm. The effect of plasma on liposomal stability at 37 °C was determined, and the association of liposomes with platelets was examined by flow cytometry. The accumulation of PEGylated phosphocholine liposomes in laser-induced thrombi was investigated in a hamster dorsal skinfold model and intravital fluorescence microscopy. Both formulations did not release TA at 37 °C. Near-complete TA release was achieved at Tm within 2.0–2.5 min of heating, which was accelerated at T > Tm. Plasma exerted a stabilizing effect on both formulations. Liposomes showed mild association with platelets. Despite positive in vitro results, fluorescently labeled liposomes did not sufficiently accumulate in laser-induced thrombi in hamsters to warrant their use in antifibrinolytic SSPLT, which can be solved by coupling thrombus-targeting ligands to the liposomes.

Thermally triggered release of a pro-osteogenic peptide from a functionalized collagen-based scaffold using thermosensitive liposomes

2014 ◽  
Vol 187 ◽  
pp. 158-166 ◽  
Author(s):  
Adolfo López-Noriega ◽  
Eduardo Ruiz-Hernández ◽  
Elaine Quinlan ◽  
Gert Storm ◽  
Wim E. Hennink ◽  
...  
Keyword(s):  
Triggered Release ◽  
Thermosensitive Liposomes ◽  
Thermally Triggered

A two-component drug delivery system using Her-2-targeting thermosensitive liposomes

2009 ◽  
Vol 17 (2) ◽  
pp. 98-107 ◽  
Author(s):  
Max Kullberg ◽  
Kristine Mann ◽  
Jesse Lee Owens
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Two Component ◽  
Her 2 ◽  
Thermosensitive Liposomes

Near-Infrared Image-Guided Delivery and Controlled Release Using Optimized Thermosensitive Liposomes

2012 ◽  
Vol 29 (8) ◽  
pp. 2092-2103 ◽  
Author(s):  
David C. Turner ◽  
Delaram Moshkelani ◽  
Colby S. Shemesh ◽  
David Luc ◽  
Hailing Zhang
Keyword(s):  
Controlled Release ◽  
Near Infrared ◽  
Infrared Image ◽  
Image Guided ◽  
Thermosensitive Liposomes
Sign in / Sign up

Export Citation Format

Share Document