Comparison of Whole-Brain Integral Dose Between Whole-Brain Radiation Therapy and Stereotactic Radiosurgery of Multiple Brain Metastases

2014 ◽  
Vol 90 (1) ◽  
pp. S908
Author(s):  
E.C. White ◽  
R. Wang ◽  
J. Rahimian
Keyword(s):  
Radiation Therapy ◽  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Whole Brain Radiation Therapy ◽  
Whole Brain ◽  
Integral Dose ◽  
Multiple Brain Metastases ◽  
Whole Brain Radiation ◽  
Brain Radiation

Simultaneously Integrated Boost to Multiple Brain Metastases during Whole Brain Radiation Therapy-Hippocampal Avoidance

Radiosurgery ◽  
2010 ◽  
pp. 247-257 ◽  
Author(s):  
Alonso N. Gutiérrez ◽  
Wolfgang A. Tomé ◽  
Amol Ghia ◽  
Sayana Thomas ◽  
George Cannon ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Brain Metastases ◽  
Whole Brain Radiation Therapy ◽  
Whole Brain ◽  
Multiple Brain Metastases ◽  
Whole Brain Radiation ◽  
Hippocampal Avoidance ◽  
Integrated Boost ◽  
Brain Radiation

scholarly journals Decision making for patients with multiple brain metastases: radiosurgery, radiotherapy, or resection?

2000 ◽  
Vol 9 (2) ◽  
pp. 1-6 ◽  
Author(s):  
Douglas Kondziolka ◽  
Atul Patel ◽  
L. Dade Lunsford ◽  
John C. Flickinger
Keyword(s):  
Radiation Therapy ◽  
Brain Metastases ◽  
Median Time ◽  
Whole Brain Radiation Therapy ◽  
Local Failure ◽  
Whole Brain ◽  
Multiple Brain Metastases ◽  
Whole Brain Radiation ◽  
Extracranial Disease ◽  
Brain Radiation

Object Multiple brain metastases are a common health problem, frequently found in patients with cancer. The prognosis, even after treatment with whole-brain radiation therapy (WBRT), is poor, with an average expected survival time of less than 6 months. Investigators at numerous centers have evaluated the role of stereotactic radiosurgery in retrospective case series of patients harboring solitary or multiple tumors. Tumor resection is used mainly for patients with large tumors that cause acute neurological syndromes. The authors conducted a randomized trial in which they compared radiosurgery combined with WBRT with WBRT alone. Methods Twenty-seven patients were randomized (14 to recieve WBRT alone and 13 to receive WBRT combined with radiosurgery). The rate of local failure at 1 year was 100% after WBRT alone but only 8% in patients in whom boost radiosurgery was performed. The median time to local failure was 6 months after WBRT alone (95% confidence interval (CI) 3.5–8.5) in comparison to 36 months (95% CI 15.6–57) after WBRT and radiosurgery (p = 0.0005). The median time to the development of any brain failure was improved in the combined modality group (p = 0.002). Survival was shown to be related to the extent of extracranial disease (p = 0.02). Conclusions Combined WBRT and radiosurgery for the treatment of patients with two to four brain metastases significantly improves control of brain disease. Whole-brain radiation therapy alone does not provide lasting and effective care when treating most patients. Surgical resection remains important for patients with large symptomatic tumors and in whom limited extracranial disease has been demonstrated.

scholarly journals The Rationale for Adjuvant Whole Brain Radiation Therapy with Radiosurgery in the Treatment of Single Brain Metastases

2003 ◽  
Vol 2 (2) ◽  
pp. 111-115 ◽  
Author(s):  
Roy A. Patchell ◽  
William F. Regine
Keyword(s):  
Radiation Therapy ◽  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Scientific Evidence ◽  
Focal Therapy ◽  
Whole Brain Radiation Therapy ◽  
Conventional Surgery ◽  
Whole Brain ◽  
Whole Brain Radiation ◽  
Brain Radiation

Randomized trials have established the efficacy of focal treatment (either stereotactic radiosurgery or conventional surgery) for single brain metastases. In the past, adjuvant whole brain radiation therapy (WBRT) was routinely given with focal therapy. Recently, the utility of adjuvant WBRT has been called into question. This paper examines the scientific evidence and the arguments, pro and con, concerning the use of adjuvant WBRT in association with stereotactic radiosurgery or conventional surgery.

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