Role of bronchoscopy in evaluation of cases with sputum smear negative pulmonary tuberculosis, interstitial lung disease and lung malignancy: A retrospective study of 712 cases

2015 ◽  
Vol 62 (1) ◽  
pp. 36-42 ◽  
Author(s):  
Raj Kumar ◽  
Nitesh Gupta
Keyword(s):  
Retrospective Study ◽  
Interstitial Lung Disease ◽  
Pulmonary Tuberculosis ◽  
Lung Disease ◽  
Sputum Smear ◽  
Lung Malignancy ◽  
Smear Negative

Role of fibreoptic bronchoscopy in sputum smear negative pulmonary tuberculosis

1994 ◽  
Vol 75 ◽  
pp. 29
Author(s):  
A. McDaniel ◽  
N. Schoenfeld ◽  
W. Frank ◽  
A. Grassot ◽  
H. Mauch ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Fibreoptic Bronchoscopy ◽  
Sputum Smear ◽  
Smear Negative

scholarly journals ROLE OF FIBREOPTIC BRONCHOSCOPY IN THE DIAGNOSIS OF SPUTUM SMEAR-NEGATIVE PULMONARY TUBERCULOSIS IN TERTIARY CARE

2016 ◽  
Vol 3 (73) ◽  
pp. 3957-3960
Author(s):  
Muthukumar Shunmugam ◽  
Joseph Pratheeban ◽  
Suresh Kumar
Keyword(s):  
Pulmonary Tuberculosis ◽  
Tertiary Care ◽  
Fibreoptic Bronchoscopy ◽  
Sputum Smear ◽  
Smear Negative

scholarly journals Role of fiberoptic bronchoscopy in sputum smear negative suspected cases of pulmonary tuberculosis: a study conducted in Southern part of Rajasthan

2020 ◽  
Vol 8 (12) ◽  
pp. 4302
Author(s):  
Atul Luhadia ◽  
Shanti K. Luhadia ◽  
Shubham Jain ◽  
Mohammad Hamza Hanfe ◽  
Divax Oza ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Diagnostic Yield ◽  
Radiological Finding ◽  
Fiberoptic Bronchoscopy ◽  
Sputum Smear ◽  
Tuberculosis Patients ◽  
Acid Fast Bacilli ◽  
Predominant Symptom ◽  
Smear Negative

Background: Sputum smear negative pulmonary tuberculosis is a common problem faced by clinicians. Fiberoptic bronchoscopy may be very useful in diagnosing these cases which have no sputum or whose sputum smear is negative for acid fast bacilli. Objective of the current study was to assess the role of fiberoptic bronchoscopy in sputum smear negative under NTEP and radiologically suspected cases of pulmonary tuberculosis.Methods: Clinico-radiological suspected cases of pulmonary tuberculosis patients in whom two sputum smear for acid fast bacilli by Ziehl Neelsen stain under NTEP was negative were included in the study. Fiberoptic bronchoscopy was performed in all these patients and samples taken were sent for investigations.Results: Fiberoptic bronchoscopy was performed in 250 patients of suspected pulmonary tuberculosis whose sputum for AFB smear was negative. Cough was the most predominant symptom. Radiologically, right side disease was more common and upper zone was most commonly involved and infiltrates were common radiological finding. During bronchoscopy, congestion and hyperaemia (36%) and mucopurulent/mucoid secretions (32%) was seen in maximum number of cases. BAL was positive in 200 patients (80%), post bronchoscopy sputum was positive in 70 cases (28%) and biopsy was positive in 12 patients out of 16 performed biopsies (75%). The total TB positive cases after combining all the methods were 215 making the overall diagnostic yield of 86%.Conclusions: Fiberoptic bronchoscopy and post bronchoscopy sputum can be very useful for diagnosing sputum for AFB smear negative but clinico-radiological suspected cases of pulmonary tuberculosis patients.

scholarly journals The Role of Bronchoscopy in the Diagnosis of Sputum Smear Negative Pulmonary Tuberculosis

2017 ◽  
Vol 05 (02) ◽  
pp. 17393-17398
Author(s):  
Vikash Gupta ◽  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Sputum Smear ◽  
Smear Negative

scholarly journals Role of induced sputum with hypertonic saline in the early diagnosis of no / inadequate sputum or sputum smear negative suspected cases of pulmonary tuberculosis

2017 ◽  
Vol 5 (11) ◽  
pp. 4761
Author(s):  
Mayank Kapur ◽  
Atul Luhadia ◽  
Shanti Kumar Luhadia
Keyword(s):  
Early Diagnosis ◽  
Pulmonary Tuberculosis ◽  
Hypertonic Saline ◽  
Invasive Procedure ◽  
Induced Sputum ◽  
Sputum Smear ◽  
Sputum Induction ◽  
Pulmonary Tb ◽  
Smear Negative

Background: Pulmonary Tuberculosis is one of the common infections in the world, especially in developing countries like India and is a leading cause of morbidity and mortality worldwide. Therefore, early diagnosis and microbiological confirmation of pulmonary TB is important. This study was done to assess the role of induced sputum with hypertonic saline in suspected pulmonary TB patients who produce no or inadequate sputum or who are sputum for AFB smear negative.Methods: 100 patients with clinical and radiological evidence of pulmonary TB with no or inadequate sputum or who are smear negative with spontaneous sputum were included in the study. Sputum was induced with 5ml of 3% hypertonic saline delivered through nebulizer and then was sent for Ziehl Neelsen staining examination.Results: 96 patients could produce adequate sputum after sputum induction. In 47 patients, sputum for AFB smear was found positive after induction.Conclusions: Sputum induction is a safe, cheap and non-invasive procedure and offers an alternative or additional approach in the diagnosis of sputum smear-negative suspected pulmonary tuberculosis patients and would enhance sensitivity for the diagnosis of tuberculosis. 

scholarly journals ROLE OF FIBEROPTIC BRONCHOSCOPY AND GENEXPERT IN EVALUATING SPUTUM SMEAR NEGATIVE PULMONARY TUBERCULOSIS SUSPECTS

2019 ◽  
Vol 6 (9) ◽  
pp. 663-667
Author(s):  
Puligunta Chakradha ◽  
Gadde Bharath ◽  
Madduri Veerasekharaiah
Keyword(s):  
Pulmonary Tuberculosis ◽  
Fiberoptic Bronchoscopy ◽  
Sputum Smear ◽  
Smear Negative

Is Immune Response Relevant in Interstitial Lung Disease?

2020 ◽  
Vol 16 (1) ◽  
pp. 18-27
Author(s):  
Manzoor M. Khan
Keyword(s):  
Immune Response ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Lung Fibrosis ◽  
Lymphocytic Infiltration ◽  
Therapeutic Strategies ◽  
Mediators Of Inflammation ◽  
Acquired Immune Responses ◽  
Novel Therapeutic Strategies

Interstitial lung disease, a term for a group of disorders, causes lung fibrosis, is mostly refractory to treatments and has a high death rate. After diagnosis the survival is up to 3 years but in some cases the patients live much longer. It involves a heterogenous group of lung diseases that exhibit progressive and irreversible destruction of the lung due to the formation of scars. This results in lung malfunction, disruption of gas exchange, and eventual death because of respiratory failure. The etiology of lung fibrosis is mostly unknown with a few exceptions. The major characteristics of the disease are comprised of injury of epithelial type II cells, increased apoptosis, chronic inflammation, monocytic and lymphocytic infiltration, accumulation of myofibroblasts, and inability to repair damaged tissue properly. These events result in abnormal collagen deposition and scarring. The inflammation process is mild, and the disease is primarily fibrotic driven. Immunosuppressants do not treat the disease but the evidence is evolving that both innate and acquired immune responses a well as the cytokines contribute to at least early progression of the disease. Furthermore, mediators of inflammation including cytokines are involved throughout the process of lung fibrosis. The diverse clinical outcome of the disease is due to different pattern of inflammatory markers. Nonetheless, the development of novel therapeutic strategies requires better understanding of the role of the immune response. This review highlights the role of the immune response in interstitial lung disease and considers the therapeutic strategies based on these observations. For this review several literature data sources were used to assess the role of the immune response in interstitial lung disease and to evaluate the possible therapeutic strategies for the disease.

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