P3-415: PATIENT-TAILORED PREDICTIONS OF GRAY MATTER ATROPHY IN ALZHEIMER'S DISEASE BASED ON BASELINE FLORTAUCIPIR AND CONNECTOME-BASED SPREAD

2006 ◽  
Vol 14 (7S_Part_23) ◽  
pp. P1265-P1266
Author(s):  
Jesse Brown ◽  
Renaud La Joie ◽  
Adrienne Visani ◽  
Howard J. Rosen ◽  
Bruce L. Miller ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gray Matter ◽  
Gray Matter Atrophy

scholarly journals Patterns of Cerebellar Gray Matter Atrophy Across Alzheimer’s Disease Progression

2018 ◽  
Vol 12 ◽  
Author(s):  
Sofia Toniolo ◽  
Laura Serra ◽  
Giusy Olivito ◽  
Camillo Marra ◽  
Marco Bozzali ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Gray Matter ◽  
Gray Matter Atrophy ◽  
Cerebellar Gray Matter

Different patterns of gray matter atrophy in early- and late-onset Alzheimer’s disease

2013 ◽  
Vol 34 (8) ◽  
pp. 2014-2022 ◽  
Author(s):  
Christiane Möller ◽  
Hugo Vrenken ◽  
Lize Jiskoot ◽  
Adriaan Versteeg ◽  
Frederik Barkhof ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gray Matter ◽  
Late Onset ◽  
Gray Matter Atrophy

Gray matter atrophy in dementia with Lewy bodies with and without concomitant Alzheimer's disease pathology

2018 ◽  
Vol 71 ◽  
pp. 171-178 ◽  
Author(s):  
Jessica J. van der Zande ◽  
Martijn D. Steenwijk ◽  
Mara ten Kate ◽  
Mike P. Wattjes ◽  
Philip Scheltens ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gray Matter ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Gray Matter Atrophy

P2-376: Dissociated gray matter atrophy and hypoperfusion in Alzheimer's disease and Parkinson's disease

2010 ◽  
Vol 6 ◽  
pp. S426-S426 ◽  
Author(s):  
Yu Zhang ◽  
Duygu Tosun ◽  
Pouria Mojabi ◽  
Marzieh Nezamzadeh ◽  
Wang Zhan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Gray Matter ◽  
Gray Matter Atrophy

[P1-416]: CSF TOTAL TAU AS A BIOMARKER FOR NEURONAL INJURY IN ALZHEIMER's DISEASE: ALIGNING RATES OF CSF CHANGE WITH RATES OF HIPPOCAMPAL AND CORTICAL GRAY MATTER ATROPHY

2017 ◽  
Vol 13 (7S_Part_8) ◽  
pp. P436-P436
Author(s):  
James D. Doecke ◽  
Qiao-Xin Li ◽  
Pierrick Bourgeat ◽  
Christopher Fowler ◽  
Steven Collins ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gray Matter ◽  
Neuronal Injury ◽  
Total Tau ◽  
Gray Matter Atrophy ◽  
Cortical Gray Matter

scholarly journals Odor Identification and Regional Gray Matter Atrophy in Patients with Alzheimer’s Disease, Parkinson’s Disease, and the Healthy Elderly: A Cross-Sectional Structural MRI Study

2021 ◽  
Vol 11 (10) ◽  
pp. 1296
Author(s):  
Simonas Jesmanas ◽  
Rymantė Gleiznienė ◽  
Mindaugas Baranauskas ◽  
Vaidas Matijošaitis ◽  
Daiva Rastenytė
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Gray Matter ◽  
Odor Identification ◽  
Identification Performance ◽  
Healthy Elderly ◽  
Gray Matter Atrophy ◽  
Deep Gray Matter

Multiple associations between impaired olfactory performance and regional cortical and deep gray matter atrophy have been reported in separate studies of patients with Alzheimer’s disease (AD), Parkinson’s disease (PD), and of the healthy elderly. We aimed to evaluate such possible associations among these populations in a unified manner. Twenty AD, twenty PD patients’ and twenty healthy age- and sex-matched controls’ odor identification performance was assessed with the Lithuanian adaptation of the Sniffin’ Sticks 12 odor identification test, followed by morphometric gray matter analysis by MRI using FreeSurfer. AD patients had significantly lower cognitive performance than both PD patients and the healthy elderly, as evaluated with the Mini-Mental State Examination (MMSE). Odor identification performance was significantly worse in AD and PD patients compared with the healthy elderly; AD patients performed slightly worse than PD patients, but the difference was not statistically significant. Among patients with AD, worse odor identification performance was initially correlated with atrophy of multiple cortical and deep gray matter regions known to be involved in olfactory processing, however, only two measures—decreased thicknesses of the right medial and left lateral orbitofrontal cortices—remained significant after adjustment for possible confounders (age, MMSE score, and global cortical thickness). Among patients with PD and the healthy elderly we found no similar statistically significant correlations. Our findings support the key role of the orbitofrontal cortex in odor identification among patients with AD, and suggest that correlations between impaired odor identification performance and regional gray matter atrophy may be relatively more pronounced in AD rather than in PD.

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