Intravenous Arginine and Citrulline Supplementation Increases Rate of Nitric Oxide Formation, Near-Infrared Spectroscopy Values and Decreases the Incidence of Necrotizing Enterocolitis in a Premature Piglet Model

Abstract Laminitis, a microvascular disease of the equine hoof leads to severe lameness. Exogenous iv 1-arginine and transdermal nitric oxide donors, such as GTN, applied to the pasterns improve lameness during acute laminitis. Near Infrared spectroscopy in an earlier study showed haemostasis and ischaemia in the hoof during acute laminitis, both were alleviated by 1-arginine. Quantitative NIRS in the present study shows that transdermal GTN increases blood flow in the equine hoof. It is concluded that glyceryl trinitrate enhances nitric oxide mediated perfusion within the equine hoof in normal and chronically laminitic horses and ponies.

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Near-Infrared Spectroscopy: A Tool for Diagnosing Necrotizing Enterocolitis at Onset of Symptoms in Preterm Neonates with Acute Gastrointestinal Symptoms?

American Journal of Perinatology ◽

10.1055/s-0040-1710033 ◽

2020 ◽

Author(s):

Julia Le Bouhellec ◽

Olivier Prodhomme ◽

Thibault Mura ◽

Aurélien Jacquot ◽

Clémentine Combes ◽

...

Keyword(s):

Infrared Spectroscopy ◽

Necrotizing Enterocolitis ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Cerebral Oxygenation ◽

Gastrointestinal Symptoms ◽

Abdominal Distension ◽

Tissue Oxygen Saturation ◽

Preterm Neonates ◽

Nirs Data

Abstract Objective In premature neonates, bloody stools and/or abdominal distension with feeding intolerance may be inaugural signs of necrotizing enterocolitis (NEC). We assessed the ability of near-infrared spectroscopy (NIRS) to distinguish those neonates with NEC soon after the occurrence of these symptoms. Study Design We prospectively collected NIRS measurements of abdominal and cerebral regional tissue oxygen saturation (r-SO2), with values masked by an opaque cover. Two physicians, blinded to the NIRS data, determined whether the gastrointestinal symptoms were related to NEC 10 days after symptom onset. Results Forty-five neonates with mean (standard deviation [SD]) gestational, birth weight and postnatal ages of 31 (3.9) weeks, 1,486 (794) g, and 18 (14) days were enrolled over 30 months. Gastrointestinal symptoms were related to NEC in 23 patients and associated with other causes in 22. Analysis of the 48 hours of monitoring revealed comparable abdominal r-SO2 and splanchnic-cerebral oxygenation ratio (SCOR) in patients with and without NEC (r-SO2: 47.3 [20.4] vs. 50.4 [17.8], p = 0.59, SCOR: 0.64 [0.26] vs. 0.69 [0.24], p = 0.51). Results were unchanged after NIRS analysis in 6-hour periods, and restriction of the analysis to severe NEC (i.e., grade 2 and 3, 57% of the NEC cases). Conclusion In this study, NIRS monitoring was unable to individualize NEC in premature infants with acute gastrointestinal symptoms.

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Erythropoietin Protects against Necrotizing Enterocolitis of Newborn Rats by the Inhibiting Nitric Oxide Formation

Neonatology ◽

10.1159/000073642 ◽

2003 ◽

Vol 84 (4) ◽

pp. 325-329 ◽

Cited By ~ 22

Author(s):

Abdullah Kumral ◽

Hüseyin Baskın ◽

Nuray Duman ◽

Osman Yilmaz ◽

Mansur Tatli ◽

...

Keyword(s):

Nitric Oxide ◽

Necrotizing Enterocolitis ◽

Newborn Rats ◽

Oxide Formation ◽

Nitric Oxide Formation

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MEASURING SPLANCHNIC TISSUE OXYGENATION IN PRETERM NEONATES WITH NECROTIZING ENTEROCOLITIS USING MULTI-SITE NEAR INFRARED SPECTROSCOPY: A PILOT STUDY COMPARING TWO ABDOMINAL LOCATIONS

Pediatric Research ◽

10.1038/pr.2011.1035 ◽

2011 ◽

Vol 70 ◽

pp. 810-810

Author(s):

E M W Kooi ◽

M E Van Der Laan ◽

J B Hulscher ◽

M Schurink ◽

A F Bos

Keyword(s):

Infrared Spectroscopy ◽

Pilot Study ◽

Necrotizing Enterocolitis ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Tissue Oxygenation ◽

Preterm Neonates

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