scholarly journals Age-related Longitudinal Psychosocial Functioning of Children with Craniofacial Anomalies

2021 ◽  
Vol 233 (5) ◽  
pp. e158
Author(s):  
Kelly X. Huang ◽  
Vivian J. Hu ◽  
Michelle K. Oberoi ◽  
Rachel M. Caprini ◽  
Harsh Patel ◽  
...  
2017 ◽  
Vol 140 (4) ◽  
pp. 776-784 ◽  
Author(s):  
Elizabeth J. Volpicelli ◽  
Miles J. Pfaff ◽  
Kevin Hakimi ◽  
James P. Bradley ◽  
R. Christian Solem ◽  
...  

2020 ◽  
Vol 145 (3) ◽  
pp. 764-773 ◽  
Author(s):  
Fransia S. De Leon ◽  
Miles J. Pfaff ◽  
Elizabeth J. Volpicelli ◽  
Hi’ilani M. K. Potemra ◽  
Johnny Lin ◽  
...  

2021 ◽  
Vol 233 (5) ◽  
pp. e163-e164
Author(s):  
Kelly X. Huang ◽  
Michelle K. Oberoi ◽  
Vivian J. Hu ◽  
Rachel M. Caprini ◽  
Sri Harshini Malapati ◽  
...  

2021 ◽  
Vol 233 (5) ◽  
pp. e160
Author(s):  
Michelle K. Oberoi ◽  
Kelly X. Huang ◽  
Vivian J. Hu ◽  
Rachel M. Caprini ◽  
Sri Harshini Malapati ◽  
...  

Author(s):  
W. Krebs ◽  
I. Krebs

Various inclusion bodies occur in vertebrate retinal photoreceptor cells. Most of them are membrane bound and associated with phagocytosis or they are age related residual bodies. We found an additional inclusion body in foveal cone cells of the baboon (Papio anubis) retina.The eyes of a 15 year old baboon were fixed by immersion in cacodylate buffered glutaraldehyde (2%)/formaldehyde (2%) as described in detail elsewhere . Pieces of retina from various locations, including the fovea, were embedded in epoxy resin such that radial or tangential sections could be cut.Spindle shaped inclusion bodies were found in the cytoplasm of only foveal cones. They were abundant in the inner segments, close to the external limiting membrane (Fig. 1). But they also occurred in the outer fibers, the perikarya, and the inner fibers (Henle’s fibers) of the cone cells. The bodies were between 0.5 and 2 μm long. Their central diameter was 0.2 to 0. 3 μm. They always were oriented parallel to the long axis of the cone cells. In longitudinal sections (Figs. 2,3) they seemed to have a fibrous skeleton that, in cross sections, turned out to consist of plate-like (Fig.4) and tubular profiles (Fig. 5).


2013 ◽  
Vol 55 ◽  
pp. 119-131 ◽  
Author(s):  
Bernadette Carroll ◽  
Graeme Hewitt ◽  
Viktor I. Korolchuk

Autophagy is a process of lysosome-dependent intracellular degradation that participates in the liberation of resources including amino acids and energy to maintain homoeostasis. Autophagy is particularly important in stress conditions such as nutrient starvation and any perturbation in the ability of the cell to activate or regulate autophagy can lead to cellular dysfunction and disease. An area of intense research interest is the role and indeed the fate of autophagy during cellular and organismal ageing. Age-related disorders are associated with increased cellular stress and assault including DNA damage, reduced energy availability, protein aggregation and accumulation of damaged organelles. A reduction in autophagy activity has been observed in a number of ageing models and its up-regulation via pharmacological and genetic methods can alleviate age-related pathologies. In particular, autophagy induction can enhance clearance of toxic intracellular waste associated with neurodegenerative diseases and has been comprehensively demonstrated to improve lifespan in yeast, worms, flies, rodents and primates. The situation, however, has been complicated by the identification that autophagy up-regulation can also occur during ageing. Indeed, in certain situations, reduced autophagosome induction may actually provide benefits to ageing cells. Future studies will undoubtedly improve our understanding of exactly how the multiple signals that are integrated to control appropriate autophagy activity change during ageing, what affect this has on autophagy and to what extent autophagy contributes to age-associated pathologies. Identification of mechanisms that influence a healthy lifespan is of economic, medical and social importance in our ‘ageing’ world.


Sign in / Sign up

Export Citation Format

Share Document