scholarly journals Comment on Comparison of lung clearance index determined by washout of N2 and SF6 in infants and preschool children with cystic fibrosis

2019 ◽  
Vol 18 (3) ◽  
pp. e26-e27
Author(s):  
Alex Horsley ◽  
Claire Nissenbaum ◽  
Lokesh Guglani ◽  
Daniel Weiner
Keyword(s):  
Cystic Fibrosis ◽  
Preschool Children ◽  
Lung Clearance ◽  
Lung Clearance Index

scholarly journals Three-center feasibility of lung clearance index in infants and preschool children with cystic fibrosis and other lung diseases

2018 ◽  
Vol 17 (2) ◽  
pp. 249-255 ◽  
Author(s):  
Mirjam Stahl ◽  
Simon Y. Graeber ◽  
Cornelia Joachim ◽  
Sandra Barth ◽  
Isabell Ricklefs ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Preschool Children ◽  
Lung Diseases ◽  
Lung Clearance ◽  
Lung Clearance Index

scholarly journals Inter-test reproducibility of the lung clearance index measured by multiple breath washout

2017 ◽  
Vol 50 (4) ◽  
pp. 1700433 ◽  
Author(s):  
Esther Oude Engberink ◽  
Felix Ratjen ◽  
Stephanie D. Davis ◽  
George Retsch-Bogart ◽  
Reshma Amin ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Preschool Children ◽  
Biological Variability ◽  
Meaningful Change ◽  
Limits Of Agreement ◽  
Intra Class Correlation ◽  
Lung Clearance ◽  
Lung Clearance Index ◽  
Multiple Breath Washout ◽  
Intra Class Correlation Coefficient

The lung clearance index (LCI) has strong intra-test repeatability; however, the inter-test reproducibility of the LCI is poorly defined.The aim of the present study was to define a physiologically meaningful change in LCI in preschool children, which discriminates changes associated with disease progression from biological variability.Repeated LCI measurements from a longitudinal cohort study of children with cystic fibrosis and age-matched controls were collected to define the inter-visit reproducibility of the LCI. Absolute change, the coefficient of variation, Bland–Altman limits of agreement, the coefficient of repeatability, intra-class correlation coefficient, and percentage changes were calculated.LCI measurements (n=505) from 71 healthy and 77 cystic fibrosis participants (aged 2.6–6 years) were analysed. LCI variability was proportional to its magnitude, such that reproducibility defined by absolute changes is biased. A physiologically relevant change for quarterly LCI measurements in health was defined as exceeding ±15%. In clinically stable cystic fibrosis participants, the threshold was higher (±25%); however, for measurements made 24 h apart, the threshold was similar to that observed in health (±17%).A percentage change in LCI greater than ±15% in preschool children can be considered physiologically relevant and greater than the biological variability of the test.

Ability of the lung clearance index to detect inflammation and infection in preschool children with cystic fibrosis

2015 ◽  
Author(s):  
Kathryn Ramsey ◽  
Sarath Ranganathan ◽  
Jasmine Grdosic ◽  
Billy Skoric ◽  
Stephen Stick ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Preschool Children ◽  
Lung Clearance ◽  
Lung Clearance Index

scholarly journals WS07-3 Effect of cumulative bacterial infection on the Lung Clearance Index in preschool children with cystic fibrosis

2019 ◽  
Vol 18 ◽  
pp. S13
Author(s):  
P. Reix ◽  
M. Klingel ◽  
S.D. Davis ◽  
G. Retsch-Bogart ◽  
S. Stanojevic ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Preschool Children ◽  
Bacterial Infection ◽  
Lung Clearance ◽  
Lung Clearance Index

scholarly journals Lung clearance index to monitor treatment response in pulmonary exacerbations in preschool children with cystic fibrosis

Thorax ◽  
2018 ◽  
Vol 73 (5) ◽  
pp. 451-458 ◽  
Author(s):  
Jonathan H Rayment ◽  
Sanja Stanojevic ◽  
Stephanie D Davis ◽  
George Retsch-Bogart ◽  
Felix Ratjen
Keyword(s):  
Cystic Fibrosis ◽  
Preschool Children ◽  
Treatment Response ◽  
Antibiotic Treatment ◽  
Treatment Effect ◽  
Average Treatment Effect ◽  
Lung Clearance ◽  
Lung Clearance Index ◽  
Pulmonary Exacerbations ◽  
Relative Change

BackgroundAntibiotic treatment for pulmonary symptoms in preschool children with cystic fibrosis (CF) varies among clinicians. The lung clearance index (LCI) is sensitive to early CF lung disease, but its utility to monitor pulmonary exacerbations in young children has not been assessed.ObjectiveWe aim to (1) understand how LCI changes during lower respiratory tract symptoms relative to a recent clinically stable measurement, (2) determine whether LCI can identify antibiotic treatment response and (3) compare LCI changes to changes in spirometric indices.MethodsLCI and spirometry were measured at quarterly clinic visits over a 12-month period in preschool children with CF. Symptomatic visits were identified and classified as treated or untreated. Treatment response was estimated using propensity score matching methods.Results104 symptomatic visits were identified in 78 participants. LCI increased from baseline in both treated (mean relative change +23.8% (95% CI 16.2 to 31.4)) and untreated symptomatic visits (mean relative change +11.2% (95% CI 2.4 to 19.9)). A significant antibiotic treatment effect was observed when LCI was used as the outcome measure (average treatment effect −15.5% (95% CI −25.4 to −5.6)) but not for z-score FEV1.ConclusionLCI significantly deteriorated with pulmonary symptoms relative to baseline and improved with antibiotic treatment. These data suggest that LCI may have a role in the routine clinical care of preschool children with CF.

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