The effect of direct hemoperfusion with polymyxin B immobilized cartridge on meropenem in critically ill patients requiring renal support

2019 ◽  
Vol 51 ◽  
pp. 71-76 ◽  
Author(s):  
Wanchana Singhan ◽  
Somratai Vadcharavivad ◽  
Nutthada Areepium ◽  
Supeecha Wittayalertpanya ◽  
Weerachai Chaijamorn ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Polymyxin B ◽  
Direct Hemoperfusion ◽  
Renal Support

scholarly journals Population Pharmacokinetics of Intravenous Polymyxin B in Critically Ill Patients: Implications for Selection of Dosage Regimens

2013 ◽  
Vol 57 (4) ◽  
pp. 524-531 ◽  
Author(s):  
Ana M. Sandri ◽  
Cornelia B. Landersdorfer ◽  
Jovan Jacob ◽  
Márcio M. Boniatti ◽  
Micheline G. Dalarosa ◽  
...  
Keyword(s):  
Population Pharmacokinetics ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Polymyxin B ◽  
Dosage Regimens ◽  
Selection Of

Evidence and Perspectives on the Use of Polymyxin B-Immobilized Fiber Column Hemoperfusion among Critically Ill Patients

2018 ◽  
pp. 215-222 ◽  
Author(s):  
Chizuru Yamashita ◽  
Kazuhiro Moriyama ◽  
Daisuke Hasegawa ◽  
Yoshitaka Hara ◽  
Naohide Kuriyama ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Polymyxin B

scholarly journals Pharmacokinetics of Intravenous Polymyxin B in Critically Ill Patients

2008 ◽  
Vol 47 (10) ◽  
pp. 1298-1304 ◽  
Author(s):  
Alexandre P. Zavascki ◽  
Luciano Z. Goldani ◽  
Guoying Cao ◽  
Silvana V. Superti ◽  
Larissa Lutz ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Polymyxin B

scholarly journals Urinary Biomarkers and Renal Recovery in Critically Ill Patients with Renal Support

2011 ◽  
Vol 6 (8) ◽  
pp. 1815-1823 ◽  
Author(s):  
Nattachai Srisawat ◽  
Xiaoyan Wen ◽  
MinJae Lee ◽  
Lan Kong ◽  
Michele Elder ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Urinary Biomarkers ◽  
Renal Recovery ◽  
Renal Support

scholarly journals Continuous extracorporeal treatments in a dialysis patient with COVID-19

2020 ◽  
Author(s):  
Yoshihito Nihei ◽  
Hajime Nagasawa ◽  
Yusuke Fukao ◽  
Masao Kihara ◽  
Seiji Ueda ◽  
...  
Keyword(s):  
Critically Ill ◽  
Distress Syndrome ◽  
Polymyxin B ◽  
Cytokine Storm ◽  
Haemophagocytic Lymphohistiocytosis ◽  
Continuous Hemodiafiltration ◽  
Timely Initiation ◽  
Direct Hemoperfusion ◽  
Treatment Approaches ◽  
Extracorporeal Treatment

Abstract The coronavirus disease 2019 (COVID-19) pandemic is now a major global health threat. More than half a year have passed since the first discovery of severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), no effective treatment has been established especially in intensive care unit. Inflammatory cytokine storm caused by SARS-CoV-2 infection has been reported to play a central role in COVID-19; therefore, treatments for suppressing cytokines, including extracorporeal treatments, are considered to be beneficial. However, until today the efficacy of removing cytokines by extracorporeal treatments in patients with COVID-19 is unclear. Herein, we report our experience with a 66-year-old male patient undergoing maintenance peritoneal dialysis who became critically ill with COVID-19 and underwent several extracorporeal treatment approaches including plasma exchange, direct hemoperfusion using a polymyxin B-immobilized fiber column and continuous hemodiafiltration. Though the patient developed acute respiratory distress syndrome (ARDS) repeatedly and subacute cerebral infarction and finally died for respiratory failure on day 30 after admission, these attempts appeared to dampen the cytokine storm based on the observed decline in serum IL-6 levels and were effective against ARDS and secondary haemophagocytic lymphohistiocytosis. This case suggests the significance of timely initiation of extracorporeal treatment approaches in critically ill patients with COVID-19.

scholarly journals Endotoxin activity assay and polymyxin B hemoperfusion use in a cohort of critically ill patients

Critical Care ◽  
2014 ◽  
Vol 18 (Suppl 1) ◽  
pp. P408
Author(s):  
SL Cutuli ◽  
G De Pascale ◽  
V Alicino ◽  
S Cicconi ◽  
V Di Gravio ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Polymyxin B ◽  
Activity Assay ◽  
Endotoxin Activity Assay ◽  
Endotoxin Activity ◽  
Polymyxin B Hemoperfusion
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