Separate and enrich water samples by using solid-phase extraction, and then conduct quantitative analysis by using the ICP-MS method for 14 species of tombarthite elements. The results show that after pretreatment, ICP-MS method could be used to measure the 14 species in water samples simultaneously and it is fast, high sensitive, 50 times of enrichment, 0.2 ng/L of method detection limit after enrichment, better precision, RSD < 5%; higher accuracy, and 93-104% of water recovery rate for simulative water samples.