Dynamics in condensed phase for systems involving phase functions obeying Gaussian statistics

Author(s):  
Alok Samanta ◽  
Swapan K. Ghosh
Author(s):  
Valery P. Sinditskii ◽  
Viacheslav Yu. Egorshev ◽  
Valery V. Serushkin ◽  
Anton I. Levshenkov ◽  
Maxim V. Berezin ◽  
...  

2021 ◽  
Vol 22 (15) ◽  
pp. 7879
Author(s):  
Yingxia Gao ◽  
Yi Zheng ◽  
Léon Sanche

The complex physical and chemical reactions between the large number of low-energy (0–30 eV) electrons (LEEs) released by high energy radiation interacting with genetic material can lead to the formation of various DNA lesions such as crosslinks, single strand breaks, base modifications, and cleavage, as well as double strand breaks and other cluster damages. When crosslinks and cluster damages cannot be repaired by the cell, they can cause genetic loss of information, mutations, apoptosis, and promote genomic instability. Through the efforts of many research groups in the past two decades, the study of the interaction between LEEs and DNA under different experimental conditions has unveiled some of the main mechanisms responsible for these damages. In the present review, we focus on experimental investigations in the condensed phase that range from fundamental DNA constituents to oligonucleotides, synthetic duplex DNA, and bacterial (i.e., plasmid) DNA. These targets were irradiated either with LEEs from a monoenergetic-electron or photoelectron source, as sub-monolayer, monolayer, or multilayer films and within clusters or water solutions. Each type of experiment is briefly described, and the observed DNA damages are reported, along with the proposed mechanisms. Defining the role of LEEs within the sequence of events leading to radiobiological lesions contributes to our understanding of the action of radiation on living organisms, over a wide range of initial radiation energies. Applications of the interaction of LEEs with DNA to radiotherapy are briefly summarized.


Photonics ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 60
Author(s):  
Milo W. Hyde

In this paper, we present a method to independently control the field and irradiance statistics of a partially coherent beam. Prior techniques focus on generating optical field realizations whose ensemble-averaged autocorrelation matches a specified second-order field moment known as the cross-spectral density (CSD) function. Since optical field realizations are assumed to obey Gaussian statistics, these methods do not consider the irradiance moments, as they, by the Gaussian moment theorem, are completely determined by the field’s first and second moments. Our work, by including control over the irradiance statistics (in addition to the CSD function), expands existing synthesis approaches and allows for the design, modeling, and simulation of new partially coherent beams, whose underlying field realizations are not Gaussian distributed. We start with our model for a random optical field realization and then derive expressions relating the ensemble moments of our fields to those of the desired partially coherent beam. We describe in detail how to generate random optical field realizations with the proper statistics. We lastly generate two example partially coherent beams using our method and compare the simulated field and irradiance moments theory to validate our technique.


Sign in / Sign up

Export Citation Format

Share Document