scholarly journals Corrigendum to “Acute and subacute toxicity studies of a new herbal formula induced apoptosis in the highly metastatic MDA-MB-231 cells” [J. King Saud Univ. Sci. 33(8) (2021) 101646]

2022 ◽  
Vol 34 (2) ◽  
pp. 101811
Author(s):  
Nael Abutaha ◽  
Saad M. Aljari ◽  
Lamya Ahmed Al-Keridis ◽  
Amin A. Al-Doaiss ◽  
Fahd AL-Mekhlafi ◽  
...  
Author(s):  
Saad M Aljari ◽  
Nael Abutaha ◽  
Lamya Ahmed Al- Keridis ◽  
Amin A. Al-Doaiss ◽  
Fahd AL-Mekhlafi ◽  
...  

Phytomedicine ◽  
2007 ◽  
Vol 14 (2-3) ◽  
pp. 209-215 ◽  
Author(s):  
A. Veerappan ◽  
S. Miyazaki ◽  
M. Kadarkaraisamy ◽  
D. Ranganathan

Author(s):  
BHARAT MISHRA ◽  
ELEZABETH JOHN ◽  
KRUPAMOL JOY ◽  
BADMANABAN R ◽  
ALEESHA R

Objective: The objective of the study was to evaluate the toxicity profile of Celastrus paniculatus (CP) by performing a preclinical study on Swiss albino mice and demonstrate a safety description through monitoring their autonomic, neurological, behavioral, physical, and biochemistry profiles. Methods: The toxicity profiles (acute and subacute) of CP were evaluated using Swiss albino mice in which they were divided into four groups: Group I received 1% Tween 20 and dimethyl sulfoxide. Group II, III, and IV received CP seed oil orally, at doses of 300, 2000, and 5000 mg/kg body weight for both acute and subacute toxicity studies in accordance with Organization for Economic Cooperation and Development guidelines No. 423. Special attention was given during the first 4 h and daily thereafter for a total of 14 days. Behavioral profile, physical state changes, and other parameters such as tremors, convulsion, lethargy were noted. Clinical signs were observed daily during the 28 days of the treatment period. Body weights were measured once a week. On the 29th day, the animals were kept to overnight and blood samples were collected through retro-orbital puncture for biochemical analysis. Results: In both acute and subacute toxicity studies, the treatment with CP did not affect the normal health status of animals. It is suggestive that CP is considered practically non-toxic. Conclusion: The toxicity profile of CP seed oil was evaluated and found to be safe until 2000 mg/kg dose.


2019 ◽  
Vol 2019 ◽  
pp. 1-12
Author(s):  
C. P. Ekanayake ◽  
M. G. Thammitiyagodage ◽  
S. Padumadasa ◽  
B. Seneviratne ◽  
C. Padumadasa ◽  
...  

Ayurvedic and traditional medical practitioners of Sri Lanka use the decoction of the immature inflorescence of Cocos nucifera L. (IC) variety aurantiaca for the treatment of menorrhagia. The progestogenic effect of the ethyl acetate soluble proanthocyanidins (EASPA) of the IC in female rats at a dose of 3.5 mg/kg body weight has been reported. Acute and subacute toxicity studies of EASPA of the IC carried out using female Wistar rats according to Organization for Economic Co-operation and Development (OECD) guidelines 423 and 407, respectively, are reported herein. In the acute toxicity study, a single dose of EASPA (2000 mg/kg body weight) was orally administered to rats, which were monitored for 14 days. In the subacute toxicity study, rats were orally administered with EASPA daily for 28 days at doses of 1.75, 3.5, 7, and 14 mg/kg body weight. No rat in either the acute or subacute toxicity study exhibited mortality or clinical signs of toxicity. Further, these rats did not show any significant change in their mean body weight, food, and water intake, haematological and biochemical parameters as well as in the results of their histopathological examinations compared to those of control group rats. According to results of the acute toxicity, the LD50 of EASPA is estimated to be greater than 2000 mg/kg body weight. Considering the results of the subacute toxicity study, the oral administration of EASPA daily for 28 days was well tolerated up to the dose, 14 mg/kg by rats. These results will be useful in the development of a novel therapeutic agent from EASPA of the IC for the treatment of menorrhagia, which incapacitates a considerable proportion of women worldwide.


2014 ◽  
Vol 39 (3) ◽  
pp. 373-382 ◽  
Author(s):  
Yoshiyuki Tago ◽  
Toshihide Fujii ◽  
Jutaro Wada ◽  
Masanori Kato ◽  
Min Wei ◽  
...  

1982 ◽  
Vol 7 (SupplementII) ◽  
pp. 63-91 ◽  
Author(s):  
Ueto TAKEDA ◽  
Masuzo ODAKI ◽  
Masayuki YOKOTA ◽  
Hitoshi SASAKI ◽  
Tetsutaro NIIZATO ◽  
...  

Author(s):  
SENTHIL KUMARI C ◽  
DHANASEKHAR KESAVELU

Objective: The objective of the study was to evaluate the toxicological potential of the ethanolic extract of leaves of Mirabilis jalapa linn through acute and subacute toxicity studies in albino Wistar rats. Methods: For acute toxicity studies, the ethanolic extract of M. jalapa was given up to 2000 mg/kg and then the animals were observed for 14 days to find out any adverse effect or death. For sub-acute toxicity studies, the exact was given for 28 days and the following parameters were observed such as changes in body weight, food intake, water intake, hematological parameters, biochemical parameters, lipid profile, urine analysis, and histopathological studies were undertaken. Results: Single oral administration of 2000 mg/kg of the ethanolic extract of M. jalapa produced no mortality or signs of toxicity. During subacute toxicity there were no changes in body weight, food intake and water intake were observed. There were no changes in lipid profile, hematological parameters, and biochemical parameters. In histopathological changes, there were no structural changes in treated groups when compared to control. Conclusion: The leaves of ethanolic extract of M. jalapa is safe when administered for 28 days. There were no deaths or signs of toxicity in treated rats during acute toxicity studies and subacute toxicity studies.


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