Rapid hardening process for starch-based powder bed 3D printing

AbstractThis study demonstrated the first case of combining novel continuous granulation with powder-based pharmaceutical 3-dimensional (3D) printing processes to enhance the dissolution rate and physical properties of a poorly water-soluble drug. Powder bed fusion (PBF) and binder jetting 3D printing processes have gained much attention in pharmaceutical dosage form manufacturing in recent times. Although powder bed-based 3D printing platforms have been known to face printing and uniformity problems due to the inherent poor flow properties of the pharmaceutical physical mixtures (feedstock). Moreover, techniques such as binder jetting currently do not provide any solubility benefits to active pharmaceutical ingredients (APIs) with poor aqueous solubility (>40% of marketed drugs). For this study, a hot-melt extrusion-based versatile granulation process equipped with UV-Vis process analytical technology (PAT) tools for the in-line monitoring of critical quality attributes (i.e., solid-state) of indomethacin was developed. The collected granules with enhanced flow properties were mixed with vinylpyrrolidone-vinyl acetate copolymer and a conductive excipient for efficient sintering. These mixtures were further characterized for their bulk properties observing an excellent flow and later subjected to a PBF-3D printing process. The physical mixtures, processed granules, and printed tablets were characterized using conventional as well as advanced solid-state characterization. These characterizations revealed the amorphous nature of the drug in the processed granules and printed tablets. Further, the in vitro release testing of the tablets with produced granules as a reference standard depicted a notable solubility advantage (100% drug released in 5 minutes at >pH 6.8) over the pure drug and the physical mixture. Our developed system known as DosePlus combines innovative continuous granulation and PBF-3D printing process which can potentially improve the physical properties of the bulk drug and formulations in comparison to when used in isolation. This process can further find application in continuous manufacturing of granules and additive manufacturing of pharmaceuticals to produce dosage forms with excellent uniformity and solubility advantage.Abstract Figure

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Effects of Post-Treatment to Improve the Surface Quality of 3D Printing Cement Mold Casting

Applied Sciences ◽

10.3390/app112411824 ◽

2021 ◽

Vol 11 (24) ◽

pp. 11824

Author(s):

Seung-Yeop Chun ◽

Geumyeon Lee ◽

Su-jin Kim ◽

Bora Jeong ◽

Jeehoon Shin ◽

...

Keyword(s):

Surface Roughness ◽

3D Printing ◽

Surface Quality ◽

Post Treatment ◽

Silica Sand ◽

Gas Generation ◽

Powder Bed ◽

Aluminum Castings ◽

Mold Casting ◽

Spherical Silica

Powder bed 3D printing can be applied to sandcasting mold manufacturing to ensure high quality and economy through process innovation. In this study, refractory alumina cement was used as an aqueous binder to ensure high-temperature thermal stability to minimize the addition of organic matter to reduce gas generation. In addition, spherical silica sand, the study material, was selected to a size of 30 µm to improve the casting mold resolution. To improve the surface quality through the post-treatment process, we confirmed the change in the surface roughness of the mold depending on the surface treatment of colloidal silica and the presence or absence of heat treatment, and finally made the mold through actual casting. Changes in the surface roughness and flowability of the cast body after mold post-treatment were confirmed. For aluminum castings, the shrinkage rate and surface roughness were confirmed in a box-shaped mold via gravity casting, and the flowability of the molten metal in the mold was confirmed in a hand-shaped mold. There was a change in the roughness and porosity of the mold, owing to the post-treatment, and the influence of the surface roughness and flowability of the cast body during actual casting was confirmed.

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Considering lithium-ion battery 3D-printing via thermoplastic material extrusion and polymer powder bed fusion

Additive Manufacturing ◽

10.1016/j.addma.2020.101651 ◽

2020 ◽

pp. 101651

Author(s):

Alexis Maurel ◽

Matti Haukka ◽

Eric MacDonald ◽

Lauri Kivijärvi ◽

Elmeri Lahtinen ◽

...

Keyword(s):

3D Printing ◽

Lithium Ion Battery ◽

Lithium Ion ◽

Powder Bed Fusion ◽

Thermoplastic Material ◽

Powder Bed ◽

Material Extrusion ◽

Polymer Powder

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Exploring Additive Manufacturing Processes for Direct 3D Printing of Copper Induction Coils

Volume 2: Advanced Manufacturing ◽

10.1115/imece2017-71685 ◽

2017 ◽

Cited By ~ 2

Author(s):

John D. Martin

Keyword(s):

Additive Manufacturing ◽

3D Printing ◽

Electron Beam Melting ◽

Energy Deposition ◽

Manufacturing Processes ◽

Powder Bed Fusion ◽

Laser Melting ◽

Powder Bed ◽

Computer Aided ◽

Directed Energy

A number of additive manufacturing processes were analyzed and compared in regards to the direct 3D printing of copper induction coils. The purpose of this study was to narrow in on 3D printing technologies that would best be suited for the manufacture of copper inductions coils. The main focus of the study was to look at how all the available additive processes could specifically be successful at creating parts made of copper pure enough to effectively conduct electricity and also geometries complex enough to meet the demands of various induction coil designs. The results of this study led to three main categories of additive manufacturing that were deemed good choices for producing copper induction coils, these included: powder bed fusion, sheet lamination, and directed energy deposition. Specific processes identified within these categories were powder bed fusion using electron beam melting and laser melting; ultrasonic additive manufacturing; and directed energy deposition utilizing laser melting and electron beam melting using both wire and powder material delivery systems. Also discussed was additional benefits that using 3D printing technology could provide beyond the physical manufacturing portion by opening doors for coupling with computer aided drafting (CAD) and computer aided engineering (CAE) software in order to create a seamless design-to-production process.

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Tensile Properties of Processed 3D Printer ZP150 Powder Material

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.699.813 ◽

2013 ◽

Vol 699 ◽

pp. 813-816 ◽

Cited By ~ 9

Author(s):

Saleh H. Gharaie ◽

Yos Morsi ◽

S.H. Masood

Keyword(s):

Mechanical Properties ◽

3D Printing ◽

Tensile Properties ◽

Powder Material ◽

Powder Materials ◽

Post Processing ◽

Infiltration Process ◽

Processing Methods ◽

Powder Bed ◽

Rp Process

3D Printing is one of the few powder-bed type rapid prototyping (RP) technologies, which allows fabrication of parts using powder materials. Understanding of mechanical properties of 3D parts made by this process is essential to explore more applications of this technology. In general, the mechanical properties of many RP produced parts depend on the process parameters andalso on post-processing methods of that RP process. Very few studies have been made to characterize the mechanical properties of 3D Printing processed parts. This paper presents an experimental investigation on how tensile properties of parts fabricated by 3D Printing is affected by 3D Printing build orientation, and by post-processing methods of infiltration process and drying of parts. Results obtained forvarious parameters are compared to investigate the optimum procedure to achieve the highest tensile strength using ZP150 powder material.

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