Structural brain and spinal cord damage in symptomatic and pre-symptomatic VAPB-related ALS

Author(s):  
Tauana B. Leoni ◽  
Thiago Junqueira R. Rezende ◽  
Thiago M. Peluzzo ◽  
Melina P. Martins ◽  
Antonio Rodrigues Coimbra Neto ◽  
...  
2008 ◽  
Vol 32 (1) ◽  
pp. 207-213
Author(s):  
Soad Abdulkareem Mohammed

In present experiment , study was done on the pathological and residual effect of malathion in mice 50 white mice randomly divided into 3 group : 1st group including (20)mice was given single oral dose .1.5 ppm in drinking water 2nd group contain (20) mice given single dose 1.5 ppm malathion orally in drinking water and repeated the same dose at 2nd and 3rd week i.e (three repeated doses), the 3rd group (10) mice act as control group .The long of experiment was 60 days , the following parameter were done . 1- Clinical Signs: treated group 1st and 2nd groups showed nausea and diarrhea 2- Pathological changes : 1st and 2nd group showed lesion which were more significant in 2nd group .Pathological changes characterized by neuron necrosis , Brain odema , and mononuclear cell present with spinal cord damage . 3- Residual investigation: which were more significant in 2nd group at 60 days of treatment, the Malathion residual reach 0.90 ppm in brain and spinal cord.  


Author(s):  
Kathryn L. Lovell ◽  
Margaret Z. Jones

Caprine β-mannosidosis, an autosomal recessive defect of glycoprotein catabolism, is associated with a deficiency of tissue and plasma -mannosidase and with tissue accumulation and urinary excretion of oligosaccharides, including the trisaccharide Man(β1-4)GlcNAc(βl-4)GlcNAc and the disaccharide Man(β1-4)GlcNAc. This genetic disorder is evident at birth, with severe neurological deficits including a marked intention tremor, pendular nystagmus, ataxia and inability to stand. Major pathological characteristics described in Nubian goats in Michigan and in Anglo-Nubian goats in New South Wales include widespread cytoplasmic vacuolation in the nervous system and viscera, axonal spheroids, and severe myelin paucity in the brain but not spinal cord or peripheral nerves. Light microscopic examination revealed marked regional variation in the severity of central nervous system myelin deficits, with some brain areas showing nearly complete absence of myelin and other regions characterized by the presence of 25-50% of the control number of myelin sheaths.


Author(s):  
Sinto Robindo ◽  
Melda Rumia Rosmeri Simorangkir

ABSTRACT All aspects of development are very important in a person's life where the development of cognition, affection and psychomotor is well developed in accordance with its development, these three aspects can be said to be good and successful if the three aspects develop well. Like wise with the psychomotor aspect where between gross motor and fine motor are also balanced. Motoric is the development of coordinated body movement control between nerves, brain, and spinal cord (spinal cord or spinal cord). Child's gross motorization can be optimized by improving his motor movement coordination skills through physical activity in the form of coordination of body movements. Like throwing, catching, kicking, running, melopat, and maintaining balance. The condition of a Down Syndrome child who experiences weakness in the ability to think will affect in all aspects of his life. Down syndrome children have problems in cognitive abilities, effective and self-care abilities. This results in them needing special education. Basically, the educational goals that children with Down Syndrome want to achieve are not different from those of education in general. Because Down Syndrome children themselves are born in the midst of society. Keywords: football sports, gross motoric, down syndrome


BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e049882
Author(s):  
Jing Nong Liang ◽  
Savanna Budge ◽  
Austin Madriaga ◽  
Kara Meske ◽  
Derrick Nguyenton ◽  
...  

IntroductionReduced neuromuscular control due to altered neurophysiological functions of the central nervous system has been suggested to cause movement deficits in individuals with patellofemoral pain (PFP). However, the underlying neurophysiological measures of brain and spinal cord in this population remain to be poorly understood. The purpose of this systematic review is to evaluate the evidence for altered cortical and spinal cord functions in individuals with PFP.Methods and analysisThe protocol for conducting the review was prepared using the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines. We will systematically search the literature that examines cortical and spinal cord functions in individuals with PFP, aged 18–45 years. The studies for cross-sectional, prospective, longitudinal, case–control and randomised control trial designs will be included from the following databases: PubMed (MEDLINE), EMBASE and Web of Science. Only studies published in English prior to 1 February 2021 will be included. The risk of bias and quality assessment will be performed using National Institutes of Health’s Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. We will conduct meta-analysis of the data where appropriate. Narrative synthesis will be taken if a meta-analysis is not possible.Ethics and disseminationThis is a systematic review from the existing literature and does not require ethical approval. The results of this study will be published in a peer-reviewed journal in the field of rehabilitation medicine, sports/orthopaedic medicine or neurology, regardless of the outcome.PROSPERO registration numberCRD42020212128.


2021 ◽  
pp. 102692
Author(s):  
Lijian Zhang ◽  
Francisco R. López-Picón ◽  
Yingqin Jia ◽  
Yao Chen ◽  
Juan Li ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shaona Acharjee ◽  
Paul M. K. Gordon ◽  
Benjamin H. Lee ◽  
Justin Read ◽  
Matthew L. Workentine ◽  
...  

AbstractMicroglia play an important role in the pathogenesis of multiple sclerosis and the mouse model of MS, experimental autoimmune encephalomyelitis (EAE). To more fully understand the role of microglia in EAE we characterized microglial transcriptomes before the onset of motor symptoms (pre-onset) and during symptomatic EAE. We compared the transcriptome in brain, where behavioral changes are initiated, and spinal cord, where damage is revealed as motor and sensory deficits. We used a RiboTag strategy to characterize ribosome-bound mRNA only in microglia without incurring possible transcriptional changes after cell isolation. Brain and spinal cord samples clustered separately at both stages of EAE, indicating regional heterogeneity. Differences in gene expression were observed in the brain and spinal cord of pre-onset and symptomatic animals with most profound effects in the spinal cord of symptomatic animals. Canonical pathway analysis revealed changes in neuroinflammatory pathways, immune functions and enhanced cell division in both pre-onset and symptomatic brain and spinal cord. We also observed a continuum of many pathways at pre-onset stage that continue into the symptomatic stage of EAE. Our results provide additional evidence of regional and temporal heterogeneity in microglial gene expression patterns that may help in understanding mechanisms underlying various symptomology in MS.


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