Study on the activation mechanism and hydration properties of gold tailings activated by mechanical-chemical-thermal coupling

We discovered that the proteostasis modulating transcription factor Nrf1 requires cytosolic de-N-glycosylation by the N-glycanase NGly1 as part of its activation mechanism. Through a covalent small molecule library screen, we discovered an inhibitor of NGly1 that blocks Nrf1 activation in cells and potentiates the activity of proteasome inhibitor cancer drugs. The requirement of NGly1 for Nrf1 activity likely underlies several pathologies associated with a rare hereditary deficiency in NGly1.

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Non-Plasmonic SERS with Silicon: Is It Really Safe? New Insights into Opto-Thermics of Core/Shell Microbeads

10.26434/chemrxiv.5813979.v1 ◽

2018 ◽

Author(s):

Nicolò Bontempi ◽

Irene Vassalini ◽

Stefano Danesi ◽

Matteo Ferroni ◽

Paolo Colombi ◽

...

Keyword(s):

Critical Role ◽

Raman Laser ◽

Core Shell ◽

Thermal Coupling ◽

Melting Points ◽

Experimental Proof ◽

Weakly Coupled ◽

Light Management ◽

Laser Sources ◽

First Time

<p>Here we investigate for the first time the opto-thermal behavior of SiO<sub>2</sub>/Si core/shell microbeads (Si-rex) irradiated with three common Raman laser sources (lambda=532, 633, 785 nm) under real working conditions. We obtained an experimental proof of the critical role played by bead size and aggregation in heat and light management, demonstrating that in the case of strong opto-thermal coupling the temperature can exceed that of the melting points of both core and shell components. In addition, we also show that weakly coupled beads can be utilized as stable substrates for plasmon-free SERS experiments.</p>

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STRUCTURAL COMPONENTS OF THE PRIVATE MEDICAL SECTOR ACTIVATION MECHANISM

Economical ◽

10.31474/1680-0044-2019-2(21)-170-177 ◽

2019 ◽

Vol 2 (2(21)) ◽

pp. 170-177

Author(s):

Anzhela Bairak ◽

Keyword(s):

Health Care ◽

Health Care System ◽

Activation Mechanism ◽

Practical Significance ◽

Structural Components ◽

Medical Sector ◽

Analysis And Synthesis ◽

Private Medicine ◽

Care System

The article examines the problems of private medicine in the health care system of the country. The aim of the article is to determine the structural components of the mechanism of activation of the private medical sector as a reserve for the provision of quality and affordable medical services and a driver for the development of the medical industry. The descriptive-analytical method, methods of analysis and synthesis, comparison, statistical, analysis and scientific generalization were used in the paper. The study substantiates the strengthening of the role of the private medical sector in the health care management system. The key problems of the domestic private medical sector and the restraining factors of its development are identified. It is concluded that it is necessary to develop a mechanism to promote the development of private medicine through a policy of active change in the health care system. The directions of activation of the private medical sector as a target reference point in the process of determining the structural elements of the organizational and economic mechanism are outlined. The structural detail of the mechanism of activation of the private medical sector for optimization of the health care system is offered. The practical significance of the obtained results is that the results of the research presented in the article are a practical basis for the development and improvement of mechanisms of public administration in the field of health care.

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