Sex Differences in the Relationship Between Arterial Stiffness and Cognitive Function in Older Adults

2022 ◽  
Vol 31 (1) ◽  
pp. 106175
Author(s):  
Elizabeth Dao ◽  
Cindy K. Barha ◽  
Mij Santos ◽  
Madison Welch ◽  
Teresa Liu-Ambrose
Keyword(s):  
Older Adults ◽  
Sex Differences ◽  
Cognitive Function ◽  
Arterial Stiffness ◽  
The Relationship

scholarly journals Sex differences in the relationship between dietary pattern adherence and cognitive function among older adults: findings from the NuAge study

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Danielle D’Amico ◽  
Matthew D. Parrott ◽  
Carol E. Greenwood ◽  
Guylaine Ferland ◽  
Pierrette Gaudreau ◽  
...  
Keyword(s):  
Older Adults ◽  
Sex Differences ◽  
Cognitive Function ◽  
Dietary Pattern ◽  
The Relationship

scholarly journals Sex differences in the relationship between dietary pattern adherence and cognitive function among older adults: Findings from the NuAge study

2020 ◽  
Author(s):  
Danielle D’Amico ◽  
Matthew D. Parrott ◽  
Carol E. Greenwood ◽  
Guylaine Ferland ◽  
Pierrette Gaudreau ◽  
...  
Keyword(s):  
Older Adults ◽  
Sex Differences ◽  
Cognitive Function ◽  
Dietary Intake ◽  
Cognitive Performance ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Community Dwelling ◽  
Western Dietary Pattern ◽  
The Relationship

Abstract Background: Consumption of a prudent dietary pattern rich in healthy nutrients is associated with enhanced cognitive performance in older adulthood, while a Western dietary pattern low in healthy nutrients is associated with poor age-related cognitive function. Sex differences exist in dietary intake among older adults; however, there is a paucity of research examining the relationship between sex-specific dietary patterns and cognitive function in later life. Methods: The current study aimed to investigate sex differences in the relationship between sex-specific dietary pattern adherence and global cognitive function at baseline and over a 3-year follow-up in 1268 community-dwelling older adults (Mage=74 years, n = 664 women, n = 612 men) from the Quebec Longitudinal Study on Nutrition and Successful Aging (NuAge). A 78-item Food Frequency Questionnaire was used to estimate dietary intake over the previous year. Sex-specific dietary pattern scores were derived using principal component analysis. Global cognition was assessed using the Modified Mini-Mental State Examination (3MS). Results: Adjusted linear mixed effects models indicated that a healthy, prudent dietary pattern was not associated with baseline cognitive performance in men or women. No relationship was found between Western dietary pattern adherence and baseline cognitive function in women. Among men, adherence to an unhealthy, Western dietary pattern was associated with poorer baseline cognitive function (b = -0.652, p = 0.02, 95% CI [-1.22, -0.65]). No association was found between prudent or Western dietary patterns and cognitive change over time in men or women. Conclusions: These findings highlight the importance of conducting sex-based analyses in aging research and suggest that the relationship between dietary pattern adherence and cognitive function in late life may be sex-dependent.

scholarly journals Sex differences in the relationship between dietary pattern adherence and cognitive function among older adults: Findings from the NuAge study

2020 ◽  
Author(s):  
Danielle D’Amico ◽  
Matthew D. Parrott ◽  
Carol E. Greenwood ◽  
Guylaine Ferland ◽  
Pierrette Gaudreau ◽  
...  
Keyword(s):  
Older Adults ◽  
Sex Differences ◽  
Cognitive Function ◽  
Dietary Intake ◽  
Cognitive Performance ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Community Dwelling ◽  
Western Dietary Pattern ◽  
The Relationship

Abstract Background Consumption of a prudent dietary pattern rich in healthy nutrients is associated with enhanced cognitive performance in older adulthood, while a Western dietary pattern low in healthy nutrients is associated with poor age-related cognitive function. Sex differences exist in dietary intake among older adults; however, there is a paucity of research examining the relationship between sex-specific dietary patterns and cognitive function in later life. Methods The current study aimed to investigate sex differences in the relationship between sex-specific dietary pattern adherence and global cognitive function at baseline and over a 3-year follow-up in 1268 community-dwelling older adults ( M age =74 years, 52% women) from the Quebec Longitudinal Study on Nutrition and Successful Aging (NuAge). A Food Frequency Questionnaire was used to estimate dietary intake. Sex-specific dietary pattern scores were derived using principal component analysis. Global cognition was assessed using the Modified Mini-Mental State Examination (3MS). Results Adjusted linear mixed effects models indicated that a healthy, prudent dietary pattern was not associated with baseline cognitive performance in men or women. No relationship was found between Western dietary pattern adherence and baseline cognitive function in women. Among men, adherence to an unhealthy, Western dietary pattern was associated with poorer baseline cognitive function ( β = -0.652, p = 0.02). No association was found between prudent or Western dietary patterns and cognitive change over time in men or women. Conclusions These findings highlight the importance of conducting sex-based analyses in aging research and suggest that the relationship between dietary pattern adherence and cognitive function in late life may be sex-dependent.

165 Sex differences in the relationship between self-reported sleep quality and frailty in South Florida older adult outpatients

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A67-A67
Author(s):  
Sonya Kaur ◽  
Katalina McInerney ◽  
Mitchell Slugh ◽  
Annelly Bure ◽  
Marina Sarno ◽  
...  
Keyword(s):  
Older Adults ◽  
Sex Differences ◽  
Sleep Quality ◽  
Grip Strength ◽  
Brain Research ◽  
Functional Independence ◽  
South Florida ◽  
Left Hand ◽  
Depression Status ◽  
The Relationship

Abstract Introduction Frailty, a multidimensional construct of decreased reserve is an important predictor of functional independence and quality of life in older adults. There is a growing body of evidence highlighting reduced sleep efficiency and sleep duration predicts frailty in older adults. However, the sex differences in these relationships have been understudied. Methods 253 participants (163) ranging in age from 50-92 years (mean= 67.59 years, S.D.= 9.22 years), underwent frailty assessment and completed the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS). Statistical moderation was assessed using nonparametric bootstrapping. All models statistically controlled for age, education and depression status. Results Higher scores on the PSQI predicted higher levels of fatigue (β=1.87, 95% CI= 0.48-3.27) and higher grip strength with the left hand (β= 0.81, 95% CI= 0.85-1.53). These relationships were significantly moderated by sex (β=-0.77, p=0.05 & β=-0.52, p=0.01). Specifically, high scores on the PSQI predicted more fatigue stronger grip strength in men (β=1.11, 95% CI=0.41-1.81) and weaker grip strength in women (β=-0.25, 95% CI=-0.51--0.02). There was no association between scores on the ESS and any of the frailty measures. Conclusion The relationships between PSQI scores and measures of fatigue and grip strength were statistically moderated by sex. These differences are not explained by sex differences in overall sleep quality or baseline frailty. This is consistent with the literature emphasizing sex differences in the effects of risk/lifestyle factors. It is possible that the relationship between sleep quality and frailty is altered by additional hormonal factors and warrant further investigation. Support (if any) This research was supported by the Evelyn F. McKnight Brain Research Foundation

Abstract W P156: Arterial Stiffness in Older Adults With and Without Stroke

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Ada Tang ◽  
Daria Shkredova ◽  
Derek W Stouth ◽  
Maureen J MacDonald ◽  
Jennifer J Heisz
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Arterial Stiffness ◽  
Cardiovascular Events ◽  
Pulse Transit Time ◽  
Group Differences ◽  
Ongoing Work ◽  
Increased Risk ◽  
Stroke Group ◽  
The Relationship

Introduction: Silent cerebrovascular infarcts resulting from vascular disease can manifest as a decline in cognitive function. These silent events are also associated with increased risk of clinically overt stroke. Arterial stiffness is a marker that represents atherosclerotic progression and is a predictor of cardiovascular events and mortality. This study examined the relationship between arterial stiffness and cognitive impairment between adults aged 50-80 years old with and without stroke. Hypothesis: We hypothesized that elevated arterial stiffness would be observed in individuals with stroke, and also be associated with increased cognitive impairment across all participants. Methods: Cognition was assessed using the Montreal Cognitive Assessment (MoCA). Arterial stiffness was quantified using carotid-femoral pulse wave velocity (cfPWV, in m/s), calculated as cfPWV=D/Δt, where D was the distance measured between arterial sites and Δt was the pulse transit time. Higher values represent increased stiffness, and values >10 m/s are associated with increased risk for cardiovascular events. Results: Twenty-five participants were assessed: 11 participants 4.7±2.4 years post-stroke and 14 older adults without stroke. The non-stroke group was older (73.1±3.9 vs. 65.2±9.4 years, P=0.009), while the stroke group had lower MoCA scores (21.2±3.2 vs. 24.4±2.8, P=0.01). There were no between-group differences in cfPWV (stroke 9.4 m/s vs. older adults 9.9 m/s, P=0.49), when controlling for age and MoCA scores. In backward regression analysis, age explained 21% of the variance of cfPWV (P=0.03), while MoCA was not a contributor. Conclusions: In conclusion, these results suggest that age is a significant correlate of arterial stiffness, regardless of the presence of stroke or cognitive impairment. Ongoing work will examine whether stroke history also contributes to arterial stiffness when groups are matched for age.

scholarly journals Physical Fitness is a Mediator in the Relationship between Arterial Stiffness and Cognitive Function

2019 ◽  
Author(s):  
Alinne Nascimento ◽  
Duarte Barros ◽  
José Oliveira ◽  
Joana Carvalho ◽  
Lucimere Bohn
Keyword(s):  
Cognitive Function ◽  
Arterial Stiffness ◽  
Physical Fitness ◽  
The Relationship

scholarly journals Engagement in Lifestyle Activities is Associated with Increased Alzheimer’s Disease-Associated Cortical Thickness and Cognitive Performance in Older Adults

2020 ◽  
Vol 9 (5) ◽  
pp. 1424 ◽  
Author(s):  
Seongryu Bae ◽  
Sangyoon Lee ◽  
Kenji Harada ◽  
Keitaro Makino ◽  
Ippei Chiba ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Cognitive Function ◽  
Direct Effect ◽  
Cortical Thickness ◽  
Social Activities ◽  
Direct Path ◽  
Cognitive Activities ◽  
Lifestyle Activities ◽  
The Relationship

The aim of this study was to examine the association between lifestyle activities, including physical, cognitive, and social activities, and Alzheimer’s disease (AD) signature cortical thickness, as well as to examine the mediating role of AD signature cortical thickness in lifestyle activities and cognitive function in community-dwelling healthy older adults. Participants were 1026 older adults who met the study inclusion criteria. The physical, cognitive, and social activities of daily life were assessed using a self-reporting questionnaire. AD signature cortical thickness was determined using FreeSurfer software. Cognitive function was evaluated using the National Center for Geriatrics and Gerontology-Functional Assessment Tool. Path analysis (based on structural equation modeling (SEM)) of cognitive activities indicated that the direct path from cognitive activities to cognitive function was significant (p < 0.001), as was the direct path from AD signature cortical thickness to cognitive function (p < 0.001). Physical (p < 0.05) or social activities (p < 0.05) had a direct effect on cognitive function. However, AD signature cortical thickness did not mediate the relationship between physical or social activities and cognitive function. Our findings suggest that higher levels of cognitive activities later in life have a significant and positive direct effect on cognitive function. Additionally, AD signature cortical thickness significantly mediates the relationship between cognitive activities and cognitive function.

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