The anti-tumor effects of CT-26 derived exosomes enriched by MicroRNA-34a on murine model of colorectal cancer

Life Sciences ◽  
2022 ◽  
Vol 290 ◽  
pp. 120234
Author(s):  
Maryam Hosseini ◽  
Kaveh Baghaei ◽  
Mahsa Hajivalili ◽  
Mohammad Reza Zali ◽  
Masoumeh Ebtekar ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Murine Model

scholarly journals Glycyrrhizin Attenuates Carcinogenesis by Inhibiting the Inflammatory Response in a Murine Model of Colorectal Cancer

2021 ◽  
Vol 22 (5) ◽  
pp. 2609
Author(s):  
Guifeng Wang ◽  
Keiichi Hiramoto ◽  
Ning Ma ◽  
Nobuji Yoshikawa ◽  
Shiho Ohnishi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Damage ◽  
Stem Cell ◽  
Inflammatory Response ◽  
Murine Model ◽  
Licorice Root ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Stem Cell Markers ◽  
Tnf Α

Glycyrrhizin (GL), an important active ingredient of licorice root, which weakens the proinflammatory effects of high-mobility group box 1 (HMGB1) by blocking HMGB1 signaling. In this study, we investigated whether GL could suppress inflammation and carcinogenesis in an azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced murine model of colorectal cancer. ICR mice were divided into four groups (n = 5, each)—control group, GL group, colon cancer (CC) group, and GL-treated CC (CC + GL) group, and sacrificed after 20 weeks. Plasma levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-α were measured using an enzyme-linked immunosorbent assay. The colonic tissue samples were immunohistochemically stained with DNA damage markers (8-nitroguanine and 8-oxo-7,8-dihydro-2′-deoxy-guanosine), inflammatory markers (COX-2 and HMGB1), and stem cell markers (YAP1 and SOX9). The average number of colonic tumors and the levels of IL-6 and TNF-α in the CC + GL group were significantly lower than those in the CC group. The levels of all inflammatory and cancer markers were significantly reduced in the CC + GL group. These results suggest that GL inhibits the inflammatory response by binding HMGB1, thereby inhibiting DNA damage and cancer stem cell proliferation and dedifferentiation. In conclusion, GL significantly attenuates the pathogenesis of AOM/DSS-induced colorectal cancer by inhibiting HMGB1-TLR4-NF-κB signaling.

Chemotherapy-induced mucositis development in a murine model of colitis-associated colorectal cancer

2019 ◽  
Vol 55 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Lauren C. Chartier ◽  
Gordon S. Howarth ◽  
Suzanne Mashtoub
Keyword(s):  
Colorectal Cancer ◽  
Murine Model

Effects of intraluminal chemotherapy on colorectal cancer – study in an orthotopic murine model

2011 ◽  
Vol 213 (3) ◽  
pp. S25
Author(s):  
Jasneet Singh Bhullar ◽  
Amir Damadi ◽  
Gokulakkrishna Subhas ◽  
S.V.S. Malladi ◽  
Jacqueline Tilak ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Murine Model ◽  
Cancer Study
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