scholarly journals ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors

Life Sciences ◽  
2022 ◽  
pp. 120284
Author(s):  
Andrea Estefanía Portales ◽  
Emilio Román Mustafá ◽  
Clara Inés McCarthy ◽  
María Paula Cornejo ◽  
Paula Monserrat Couto ◽  
...  
2011 ◽  
Vol 7 (4) ◽  
pp. 254 ◽  
Author(s):  
Giuliano Tocci ◽  
Lorenzo Castello ◽  
Massimo Volpe ◽  
◽  
◽  
...  

The renin–angiotensin system (RAS) has a key role in the maintenance of cardiovascular homeostasis, and water and electrolyte metabolism in healthy subjects, as well as in several diseases including hypertension, left ventricular hypertrophy and dysfunction, coronary artery disease, renal disease and congestive heart failure. These conditions are all characterised by abnormal production and activity of angiotensin II, which represents the final effector of the RAS. Over the last few decades, accumulating evidence has demonstrated that antihypertensive therapy based on angiotensin II receptor blockers (ARBs) has a major role in the selective antagonism of the main pathological activities of angiotensin II. Significant efforts have been made to demonstrate that blocking the angiotensin II receptor type 1 (AT1) subtype receptors through ARB-based therapy results in proven benefits in different clinical settings. In this review, we discuss the main benefits of antihypertensive strategies based on ARBs in terms of their efficacy, safety and tolerability.


2013 ◽  
Vol 19 (17) ◽  
pp. 3002-3008 ◽  
Author(s):  
Satoshi Imaizumi ◽  
Shin-ichiro Miura ◽  
Eiji Yahiro ◽  
Yoshinari Uehara ◽  
Issei Komuro ◽  
...  

Circulation ◽  
1995 ◽  
Vol 92 (1) ◽  
pp. 88-95 ◽  
Author(s):  
Shokei Kim ◽  
Masaki Kawamura ◽  
Hideki Wanibuchi ◽  
Kensuke Ohta ◽  
Akinori Hamaguchi ◽  
...  

Hypertension ◽  
1997 ◽  
Vol 30 (3) ◽  
pp. 345-350 ◽  
Author(s):  
Donna H. Wang ◽  
Jingxin Qiu ◽  
Zhaoyong Hu ◽  
Yong Du

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