Polycaprolactone/polyvinyl alcohol core-shell nanofibers as a pH-responsive drug carrier for the potential application in chemotherapy against colon cancer

2021 ◽  
Vol 291 ◽  
pp. 129516
Author(s):  
Eryun Yan ◽  
Jinyu Jiang ◽  
Xihua Ren ◽  
Jianwei Gao ◽  
Xunhai Zhang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Polyvinyl Alcohol ◽  
Potential Application ◽  
Drug Carrier ◽  
Core Shell ◽  
Ph Responsive

Highly efficient sunitinib release from pH-responsive mHPMC@Chitosan core-shell nanoparticles

2021 ◽  
Vol 258 ◽  
pp. 117719
Author(s):  
Hessam Jafari ◽  
Gholam Reza Mahdavinia ◽  
Bagher Kazemi ◽  
Hermann Ehrlich ◽  
Yvonne Joseph ◽  
...  
Keyword(s):  
Core Shell ◽  
Ph Responsive ◽  
Shell Nanoparticles ◽  
Highly Efficient ◽  
Core Shell Nanoparticles

scholarly journals Bacteriophage Encapsulation in pH-Responsive Core-Shell Capsules as an Animal Feed Additive

Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1131
Author(s):  
Kerry Richards ◽  
Danish J. Malik
Keyword(s):  
Animal Feed ◽  
Feed Additive ◽  
Core Shell ◽  
Ph Responsive ◽  
Zoonotic Infections ◽  
The Core ◽  
Extrusion Processing ◽  
Food Borne ◽  
Wet Heat ◽  
Food Borne Infections

Increasing antibiotic resistance in bacteria that cause zoonotic infections is a major problem for farmers rearing animals for food as well as for consumers who eat the contaminated meat resulting in food-borne infections. Bacteriophages incorporated in animal feed may help reduce carriage and infections in animals including chickens and pigs. There are, however, unmet challenges in protecting phages from processing stresses e.g., during animal feed pelleting operations and during transit of phages through the acidic gastric environment. Core-shell capsules were produced using a concentric nozzle and commercially available encapsulation equipment to fabricate capsules with phages formulated in an oil-in-water microemulsion in the core. pH-responsive capsules released the encapsulated phage cargo within 10–30 min triggered by changes in local environmental pH typically found in the lower gastrointestinal (GI) tract of animals. Acid stability of phages exposed to pH values as low as pH 1 was demonstrated. Encapsulated phages were able to withstand exposure to 95 °C wet heat thermal stress for up to 120 s, conditions typically encountered during feed pellet extrusion processing. Free phages were inactivated within 15 s under these conditions. The present study demonstrates that encapsulation of bacteriophages in core-shell pH-responsive capsules with water-in-oil emulsified phages in the core significantly improves phage viability upon exposure to processing and environmental stresses that require consideration during production of animal feed and application in animals for biocontrol. The results from this study should help guide future development of phage formulations suitable for use in animal feed for animal biocontrol applications.

pH-Responsive Nanoscale Covalent Organic Polymers as a Biodegradable Drug Carrier for Combined Photodynamic Chemotherapy of Cancer

2018 ◽  
Vol 10 (17) ◽  
pp. 14475-14482 ◽  
Author(s):  
Hairong Wang ◽  
Wenwen Zhu ◽  
Jingjing Liu ◽  
Ziliang Dong ◽  
Zhuang Liu
Keyword(s):  
Drug Carrier ◽  
Organic Polymers ◽  
Ph Responsive

Fabrication of pH Responsive Core-Shell Nanosystem with Low-Temperature Photothermal Therapy Effect for Treating Bacterial Biofilm Infection

2021 ◽  
Author(s):  
Dan Peng ◽  
Genhua Liu ◽  
Ye He ◽  
Pengfei Gao ◽  
Shuangquan Gou ◽  
...  
Keyword(s):  
Low Temperature ◽  
Photothermal Therapy ◽  
Normal Tissue ◽  
Bacterial Biofilm ◽  
Alternative Strategy ◽  
Viable Alternative ◽  
Core Shell ◽  
Ph Responsive ◽  
Therapy Effect ◽  
Biofilm Infection

Recently, photothermal therapy (PTT) has been recognized as a viable alternative strategy against bacterial biofilm infection. However, hyperthermia required for PTT to ablate biofilm usually induced damage of normal tissue/organ...

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