Animal models in vaccinology: state of the art and future perspectives for an animal-free approach

2022 ◽  
Vol 66 ◽  
pp. 46-55
Author(s):  
Emiliano Chiarot ◽  
Mariagrazia Pizza
2020 ◽  
Vol 9 (1) ◽  
pp. 303-322 ◽  
Author(s):  
Zhifang Zhao ◽  
Tianqi Qi ◽  
Wei Zhou ◽  
David Hui ◽  
Cong Xiao ◽  
...  

AbstractThe behavior of cement-based materials is manipulated by chemical and physical processes at the nanolevel. Therefore, the application of nanomaterials in civil engineering to develop nano-modified cement-based materials is a promising research. In recent decades, a large number of researchers have tried to improve the properties of cement-based materials by employing various nanomaterials and to characterize the mechanism of nano-strengthening. In this study, the state of the art progress of nano-modified cement-based materials is systematically reviewed and summarized. First, this study reviews the basic properties and dispersion methods of nanomaterials commonly used in cement-based materials, including carbon nanotubes, carbon nanofibers, graphene, graphene oxide, nano-silica, nano-calcium carbonate, nano-calcium silicate hydrate, etc. Then the research progress on nano-engineered cementitious composites is reviewed from the view of accelerating cement hydration, reinforcing mechanical properties, and improving durability. In addition, the market and applications of nanomaterials for cement-based materials are briefly discussed, and the cost is creatively summarized through market survey. Finally, this study also summarizes the existing problems in current research and provides future perspectives accordingly.


Diversity ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 129
Author(s):  
María Capa ◽  
Pat Hutchings

Annelida is a ubiquitous, common and diverse group of organisms, found in terrestrial, fresh waters and marine environments. Despite the large efforts put into resolving the evolutionary relationships of these and other Lophotrochozoa, and the delineation of the basal nodes within the group, these are still unanswered. Annelida holds an enormous diversity of forms and biological strategies alongside a large number of species, following Arthropoda, Mollusca, Vertebrata and perhaps Platyhelminthes, among the species most rich in phyla within Metazoa. The number of currently accepted annelid species changes rapidly when taxonomic groups are revised due to synonymies and descriptions of a new species. The group is also experiencing a recent increase in species numbers as a consequence of the use of molecular taxonomy methods, which allows the delineation of the entities within species complexes. This review aims at succinctly reviewing the state-of-the-art of annelid diversity and summarizing the main systematic revisions carried out in the group. Moreover, it should be considered as the introduction to the papers that form this Special Issue on Systematics and Biodiversity of Annelids.


2021 ◽  
pp. 1-9
Author(s):  
Horacio Merchant-Larios ◽  
Verónica Díaz-Hernández ◽  
Diego Cortez

The discovery in mammals that fetal testes are required in order to develop the male phenotype inspired research efforts to elucidate the mechanisms underlying gonadal sex determination and differentiation in vertebrates. A pioneer work in 1966 that demonstrated the influence of incubation temperature on sexual phenotype in some reptilian species triggered great interest in the environment’s role as a modulator of plasticity in sex determination. Several chelonian species have been used as animal models to test hypotheses concerning the mechanisms involved in temperature-dependent sex determination (TSD). This brief review intends to outline the history of scientific efforts that corroborate our current understanding of the state-of-the-art in TSD using chelonian species as a reference.


Author(s):  
Joost van Hoof ◽  
Hannah R. Marston

The number of older adults is increasing rapidly, and this demographic shift places an increased level of strain and tension on the various international healthcare and welfare systems [...]


Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 137
Author(s):  
Chun-Yan Shih ◽  
Pei-Ting Wang ◽  
Wu-Chou Su ◽  
Hsisheng Teng ◽  
Wei-Lun Huang

Since the first clinical cancer treatment in 1978, photodynamic therapy (PDT) technologies have been largely improved and approved for clinical usage in various cancers. Due to the oxygen-dependent nature, the application of PDT is still limited by hypoxia in tumor tissues. Thus, the development of effective strategies for manipulating hypoxia and improving the effectiveness of PDT is one of the most important area in PDT field. Recently, emerging nanotechnology has benefitted progress in many areas, including PDT. In this review, after briefly introducing the mechanisms of PDT and hypoxia, as well as basic knowledge about nanomedicines, we will discuss the state of the art of nanomedicine-based approaches for assisting PDT for treating hypoxic tumors, mainly based on oxygen replenishing strategies and the oxygen dependency diminishing strategies. Among these strategies, we will emphasize emerging trends about the use of nanoscale metal–organic framework (nMOF) materials and the combination of PDT with immunotherapy. We further discuss future perspectives and challenges associated with these trends in both the aspects of mechanism and clinical translation.


Biomaterials ◽  
2021 ◽  
Vol 270 ◽  
pp. 120682
Author(s):  
Qinghua Lyu ◽  
Ling Peng ◽  
Xiangqian Hong ◽  
Taojian Fan ◽  
Jingying Li ◽  
...  

2014 ◽  
Vol 88 (12) ◽  
pp. 2071-2075 ◽  
Author(s):  
Dirk Drasdo ◽  
Johannes Bode ◽  
Uta Dahmen ◽  
Olaf Dirsch ◽  
Steven Dooley ◽  
...  

2016 ◽  
Vol 155 (1) ◽  
pp. S27-S40 ◽  
Author(s):  
P. Damborg ◽  
E.M. Broens ◽  
B.B. Chomel ◽  
S. Guenther ◽  
F. Pasmans ◽  
...  

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