scholarly journals The proteasome-ubiquitin pathway in the Schistosoma mansoni egg has development- and morphology-specific characteristics

2011 ◽  
Vol 175 (2) ◽  
pp. 118-125 ◽  
Author(s):  
William Mathieson ◽  
William Castro-Borges ◽  
R. Alan Wilson
Keyword(s):  
Schistosoma Mansoni ◽  
Ubiquitin Pathway

Ultrastructural analysis of “Sensory” surface nerve endings and “putative” neurotransmitter sites in Schistosoma mansoni Miracidia

1989 ◽  
Vol 47 ◽  
pp. 962-963
Author(s):  
Betty Ruth Jones ◽  
Steve Chi-Tang Pan
Keyword(s):  
Nervous System ◽  
Life Cycle ◽  
Schistosoma Mansoni ◽  
Snail Host ◽  
Complex Life Cycle ◽  
Rational Approach ◽  
Effective Control ◽  
The Social ◽  
Social And Economic Development ◽  
Basic Biology

INTRODUCTION: Schistosomiasis has been described as “one of the most devastating diseases of mankind, second only to malaria in its deleterious effects on the social and economic development of populations in many warm areas of the world.” The disease is worldwide and is probably spreading faster and becoming more intense than the overall research efforts designed to provide the basis for countering it. Moreover, there are indications that the development of water resources and the demands for increasing cultivation and food in developing countries may prevent adequate control of the disease and thus the number of infections are increasing.Our knowledge of the basic biology of the parasites causing the disease is far from adequate. Such knowledge is essential if we are to develop a rational approach to the effective control of human schistosomiasis. The miracidium is the first infective stage in the complex life cycle of schistosomes. The future of the entire life cycle depends on the capacity and ability of this organism to locate and enter a suitable snail host for further development, Little is known about the nervous system of the miracidium of Schistosoma mansoni and of other trematodes. Studies indicate that miracidia contain a well developed and complex nervous system that may aid the larvae in locating and entering a susceptible snail host (Wilson, 1970; Brooker, 1972; Chernin, 1974; Pan, 1980; Mehlhorn, 1988; and Jones, 1987-1988).

In vitro schistosomicidal activity of Usnea steineri extract and its major constituent (+)-usnic acid against Schistosoma mansoni

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
AIO Salloum ◽  
R Lucarini ◽  
MG Tozatti ◽  
J Medeiros ◽  
MLA Silva ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Usnic Acid ◽  
Major Constituent

Hepatozelluläre Aktivierung von β-Catenin und Survivin durch Schistosoma mansoni Infektion im Hamster-Modell

2019 ◽  
Author(s):  
M Roderfeld ◽  
J Lichtenberger ◽  
F Wolters ◽  
T Quack ◽  
CG Grevelding ◽  
...  
Keyword(s):  
Schistosoma Mansoni

Schistosoma mansoni-Eier regulieren den hepatischen Kohlenhydrat-Stoffwechsel des Wirts

2020 ◽  
Author(s):  
SM Gindner ◽  
V von Bülow ◽  
L Hehr ◽  
N Buß ◽  
G Schramm ◽  
...  
Keyword(s):  
Schistosoma Mansoni

Mielopatía por Schistosoma mansoni. Descripción de dos casos y revisión de la bibliografía

2004 ◽  
Vol 39 (02) ◽  
pp. 137
Author(s):  
Francisco Javier Carod Artal ◽  
Antonio Pedro Vargas
Keyword(s):  
Schistosoma Mansoni

Ultrastructural alterations in adult Schistosoma mansoni harbored in low-inflammatory mice.

2013 ◽  
Vol 4 ◽  
Author(s):  
Xavier Aurelizia Maria ◽  
Tavares Daniel ◽  
Guimar�es Erick ◽  
Da Silva Antonio Carlos ◽  
De Moraes Neto Antonio Henrique
Keyword(s):  
Schistosoma Mansoni ◽  
Ultrastructural Alterations

Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma Mansoni (SmSirt2)

2019 ◽  
Author(s):  
Daria Monaldi ◽  
Dante Rotili ◽  
Julien Lancelot ◽  
Martin Marek ◽  
Nathalie Wössner ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Human Cancer ◽  
Egg Laying ◽  
Human Cancer Cells ◽  
Parasite Survival ◽  
Survival And Reproduction ◽  
Emergence Of Resistance ◽  
First Time ◽  
Parasitic Life Cycle

The only drug for treatment of Schistosomiasis is Praziquantel, and the possible emergence of resistance makes research on novel therapeutic agents necessary. Targeting of Schistosoma mansoni epigenetic enzymes, which regulate the parasitic life cycle, emerged as promising approach. Due to the strong effects of human Sirtuin inhibitors on parasite survival and reproduction, Schistosoma sirtuins were postulated as therapeutic targets. In vitro testing of synthetic substrates of S. mansoni Sirtuin 2 (SmSirt2) and kinetic experiments on a myristoylated peptide demonstrated lysine long chain deacylation as an intrinsic SmSirt2 activity for the first time. Focused in vitro screening of the GSK Kinetobox library and structure-activity relationships (SAR) of identified hits, led to the first SmSirt2 inhibitors with activity in the low micromolar range. Several SmSirt2 inhibitors showed potency against both larval schistosomes (viability) and adult worms (pairing, egg laying) in culture without general toxicity to human cancer cells.<br>

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