Mir-142-5p as an indicator of autoimmune processes in childhood idiopathic nephrotic syndrome and as a part of MicroRNAs expression panels for its diagnosis and prediction of response to steroid treatment

2022 ◽  
Vol 141 ◽  
pp. 21-32
Author(s):  
Noha Rabie Bayomy ◽  
Wafaa Moustafa Abo Alfottoh ◽  
Shaimaa Ahmed Ali Eldeep ◽  
Asmaa Mohamed Salah Ibrahim Mabrouk Mersal ◽  
Hamed Mohamed Amer Abd El- Bary ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Idiopathic Nephrotic Syndrome ◽  
Steroid Treatment ◽  
Prediction Of Response ◽  
Autoimmune Processes

ABCB1 polymorphisms and steroid treatment in children with idiopathic nephrotic syndrome

2016 ◽  
Vol 74 (1) ◽  
pp. 36-41 ◽  
Author(s):  
Manal A. Safan ◽  
Nesreen G. Elhelbawy ◽  
Dina A. Midan ◽  
Heba F. Khader
Keyword(s):  
Nephrotic Syndrome ◽  
Idiopathic Nephrotic Syndrome ◽  
Steroid Treatment

Growth in boys with idiopathic nephrotic syndrome on long-term cyclosporin and steroid treatment

2009 ◽  
Vol 24 (12) ◽  
pp. 2393-2400 ◽  
Author(s):  
Valérie Leroy ◽  
Véronique Baudouin ◽  
Corinne Alberti ◽  
Geneviève Guest ◽  
Patrick Niaudet ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Idiopathic Nephrotic Syndrome ◽  
Steroid Treatment

scholarly journals SP915THE LONG TERM OUTLOOK TO FINAL OUTCOME AND STEROID TREATMENT RESULTS IN CHILDREN WITH IDIOPATHIC NEPHROTIC SYNDROME

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii678-iii678
Author(s):  
Nida Dinçel ◽  
Ebru Yılmaz ◽  
S¸ükriye Hacıkara ◽  
I˙pek Kaplan Bulut ◽  
Sevgi Mir
Keyword(s):  
Nephrotic Syndrome ◽  
Idiopathic Nephrotic Syndrome ◽  
Steroid Treatment ◽  
Final Outcome ◽  
Treatment Results

scholarly journals The long-term outlook to final outcome and steroid treatment results in children with idiopathic nephrotic syndrome

Renal Failure ◽  
2015 ◽  
Vol 37 (8) ◽  
pp. 1267-1272 ◽  
Author(s):  
Nida Dinçel ◽  
Ebru Yılmaz ◽  
İpek Kaplan Bulut ◽  
Şükriye Hacıkara ◽  
Sevgi Mir
Keyword(s):  
Nephrotic Syndrome ◽  
Idiopathic Nephrotic Syndrome ◽  
Steroid Treatment ◽  
Final Outcome ◽  
Treatment Results

Genetic polymorphisms influence the steroid treatment of children with idiopathic nephrotic syndrome

2012 ◽  
Vol 27 (9) ◽  
pp. 1511-1517 ◽  
Author(s):  
Yee-Hsuan Chiou ◽  
Lin-Yu Wang ◽  
Tzu-Hui Wang ◽  
Shiao-ping Huang
Keyword(s):  
Nephrotic Syndrome ◽  
Genetic Polymorphisms ◽  
Idiopathic Nephrotic Syndrome ◽  
Steroid Treatment

RNA expression as a prognostic tool in idiopathic nephrotic syndrome

2007 ◽  
Vol 148 (23) ◽  
pp. 1067-1075
Author(s):  
Krisztina Fischer ◽  
Orsolya Galamb ◽  
Béla Molnár ◽  
Zsolt Tulassay ◽  
András Szabó
Keyword(s):  
Nephrotic Syndrome ◽  
Northern Blot ◽  
Idiopathic Nephrotic Syndrome ◽  
Minimal Change ◽  
Ribonuclease Protection Assay ◽  
Rna Expression ◽  
Rt Pcr ◽  
Protection Assay ◽  
Ribonuclease Protection

A gyermekkori nephrosis 90%-a idiopathiás nephrosis szindróma. Az idetartozó három kórkép, a minimal change betegség, a mesangialis proliferatio és a focalis sclerosis hasonló klinikai képpel jelentkező, eltérő prognózisú és terápiás válaszú betegség. Dolgozatunk célja az idiopathiás nephrosis szindrómába tartozó kórképek kialakulásával, progressziójával összefüggő genetikai ismeretek, génexpressziós változások áttekintése és funkcionális csoportosítása. A génexpressziós változások meghatározásának eszközeként, dolgozatunk röviden összefoglalja a northern blot, a ribonuclease protection assay, az in situ RNS-hibridizáció, a kvantitatív RT-PCR és a microarray módszerek lényegét. Az eddig elvégzett vizsgálatok a DNS-szintézis és repair gének, növekedési faktorok, extracelluláris mátrix, extracelluláris ligandreceptorok, extracelluláris jelátvitel zavarai mellett kiemelik a metabolikus és transzporter gének, illetve az immunszabályozó gének molekuláris eltéréseit, amelyek összefüggésben vannak az idiopathiás nephrosis szindróma eddig megismert molekuláris hátterével. A chiptechnológia fejlődésével és elterjedésével ezek a markerek és a hagyományos vizsgálati módszerek párhuzamos alkalmazása rutindiagnosztikai szempontból is fontossá válhat.

scholarly journals Steroid treatment for the first episode of childhood nephrotic syndrome: comparison of the 8 and 12 weeks regimen using an individual patient data meta-analysis

2021 ◽  
Author(s):  
Anne M. Schijvens ◽  
Nynke Teeninga ◽  
Eiske M. Dorresteijn ◽  
Steven Teerenstra ◽  
Nicholas J. Webb ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Steroid Treatment ◽  
First Episode ◽  
Childhood Nephrotic Syndrome ◽  
Steroid Sensitive Nephrotic Syndrome ◽  
Steroid Sensitive ◽  
First Relapse ◽  
Steroid Regimen

AbstractSteroids are the cornerstone of the treatment of childhood nephrotic syndrome. The optimal duration for the first episode remains a matter of debate. The aim of this study is to determine whether the 8 weeks International Study of Kidney Disease in Children (ISKDC) regimen is equally effective as the 12 weeks steroid regimen from the German society of pediatric nephrology (Arbeitsgemeinschaft für Pädiatrische Nephrologie [APN]). An individual patient data (IPD) meta-analysis of randomized controlled trials reporting on prednisolone treatment for a first episode of childhood nephrotic syndrome was conducted. European trials aimed at investigating the ISKDC and/or APN steroid regimen were selected. The lead investigators of the selected trials were requested to provide the IPD of the specific treatment groups. Four trials included European cohorts using dosing schedules according to the regimens studied. IPD of two trials were available. A significant difference was found in time to first relapse after cessation of steroid treatment between the 8 and 12 weeks treatment group with a median time to relapse of 29 and 63 days, respectively. Moreover, relapse rate ratios during total follow-up were 51% higher for the 8 weeks regimen. Finally, younger children have a significantly lower time to first relapse and frequently relapsing nephrotic syndrome.Conclusions: The results of this IPD meta-analysis suggest that the 8 weeks steroid regimen for a first episode of steroid-sensitive nephrotic syndrome may not be equally effective as the 12 weeks steroid regimen. Moreover, this study highlights the importance of using uniform definitions to enable accurate comparison and interpretation of trial results.Trial registration: Registration number: CRD42020199244, date of registration 16-08-2020 What is Known:• Steroids are the cornerstone of the treatment of childhood nephrotic syndrome, however the optimal duration for the first episode remains a matter of debate.• Currently, the 8 weeks ISKDC protocol and 12 weeks APN protocol are among the most frequently used protocols in Europe. What is New:• The 8 weeks steroid regimen for a first episode of steroid-sensitive nephrotic syndrome may not be equally effective as the 12 weeks steroid regimen for the treatment of a first episode of nephrotic syndrome.• Younger children have a significantly shorter time to first relapse and time to frequent relapsing nephrotic syndrome.

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