Cognitive rehabilitation outcomes in patients with Multiple sclerosis: Preliminary data about the potential role of personality traits

Author(s):  
Maria Grazia Maggio ◽  
Maria Chiara Stagnitti ◽  
Patrizia Calatozzo ◽  
Serena Formica ◽  
Desiree Latella ◽  
...  
2021 ◽  
pp. 132-135
Author(s):  
Joyeta Ghosh

Multiple sclerosis (MS) is dened as one chronic disease of central nervous system with neurodegenerative and inammatory components, where most of the patients shown a relapsingremitting course dened by the acute inception of focal neurologic decits and consistent focal inammatory changes visible on MRI. The causal factor of this complicated autoimmune and neurodegenerative disease is still unknown. Mitochondrial dysfunction is the key contributor to the neurodegenerative process of this disease. The current review signies the possible potential role of mitochondria in MS and the different dietary approach as a disease modier with the special emphasis on mitochondrial function and neurodegenerations.Research regarding therapeutic implementation of different diet in MS is advancing day by day; but currently remains with limited data. Few studies have been intended with meticulously collected observations, and the very few clinical trials that have been executed with insufcient sample size or length to adequately assess efcacy. More epidemiological and observational studies on dietary implementations were required


2014 ◽  
Vol 36 (2) ◽  
pp. 105-113 ◽  
Author(s):  
Maryam Roozbeh ◽  
Hemn Mohammadpour ◽  
Gholamreza Azizi ◽  
Samira Ghobadzadeh ◽  
Abbas Mirshafiey

2014 ◽  
Vol 20 (2) ◽  
pp. 135-140 ◽  
Author(s):  
Yuan Zhou ◽  
Steve Simpson ◽  
Adele F Holloway ◽  
Jac Charlesworth ◽  
Ingrid van der Mei ◽  
...  

It is now well established that both genetic and environmental factors contribute to and interact in the development of multiple sclerosis (MS). However, the currently described causal genetic variants do not explain the majority of the heritability of MS, resulting in ‘missing heritability’. Epigenetic mechanisms, which principally include DNA methylation, histone modifications and microRNA-mediated post-transcriptional gene silencing, may contribute a significant component of this missing heritability. As the development of MS is a dynamic process potentially starting with inflammation, then demyelination, remyelination and neurodegeneration, we have reviewed the dynamic epigenetic changes in these aspects of MS pathogenesis and describe how environmental risk factors may interact with epigenetic changes to manifest in disease.


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