Acute disseminated candidiasis due to Candida tropicalis with skin and muscular lesions in a patient with Tcell acute lymphocytic leukemia (T-ALL).

In Acute Lymphocytic Leukemia motility of lymphocytes is associated with dissemination of malignancy and establishment of metastatic foci. Normal and leukemic lymphocytes in circulation reach solid tissues where due to in adequate perfusion some cells get trapped among tissue spaces. Although normal lymphocytes reenter into circulation leukemic lymphocytes are thought to remain entrapped owing to reduced mobility and form secondary metastasis. Cell surface, transmembrane interactions, cytoskeleton and level of cell differentiation are implicated in lymphocyte mobility. An attempt has been made to correlate ultrastructural information with quantitative data obtained by Laser Doppler Velocimetry (LDV). TEM of normal & leukemic lymphocytes revealed heterogeneity in cell populations ranging from well differentiated (Fig. 1) to poorly differentiated cells (Fig. 2). Unlike other cells, surface extensions in differentiated lymphocytes appear to originate by extrusion of large vesicles in to extra cellular space (Fig. 3). This results in persistent unevenness on lymphocyte surface which occurs due to a phenomenon different from that producing surface extensions in other cells.

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Livedo reticularis in association with acute lymphocytic leukemia. Report of a case

Archives of Dermatology ◽

10.1001/archderm.92.2.160 ◽

1965 ◽

Vol 92 (2) ◽

pp. 160-161

Author(s):

G. L. Popkin

Keyword(s):

Acute Lymphocytic Leukemia ◽

Lymphocytic Leukemia ◽

Livedo Reticularis

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Deregulated expression of prostate apoptosis response gene-4 in less differentiated lymphocytes and inverse expressional patterns of par-4 and bcl-2 in acute lymphocytic leukemia

The Hematology Journal ◽

10.1038/sj.thj.6200089 ◽

2001 ◽

Vol 2 (2) ◽

pp. 103-107 ◽

Cited By ~ 26

Author(s):

Simone Boehrer ◽

Kai U Chow ◽

Elena Puccetti ◽

Martin Ruthardt ◽

Shahrzad Godzisard ◽

...

Keyword(s):

Acute Lymphocytic Leukemia ◽

Lymphocytic Leukemia ◽

Response Gene ◽

Gene 4

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New Therapeutic Approach to Reduce Methotrexate Toxicity after High-Dose Chemotherapy in a Child with Acute Lymphocytic Leukemia: Efficacy and Safety of Hemoadsorption with HA-230 Adsorber

Blood Purification ◽

10.1159/000514135 ◽

2021 ◽

pp. 1-5

Author(s):

Vitaliy Sazonov ◽

Zaure Tobylbayeva ◽

Askhat Saparov ◽

Bolatbek Jubaniyazov ◽

Samat Issakov ◽

...

Keyword(s):

Acute Lymphocytic Leukemia ◽

Pediatric Patients ◽

High Dose Chemotherapy ◽

The Body ◽

Lymphocytic Leukemia ◽

High Dose ◽

Successful Implementation ◽

Efficacy And Safety ◽

Related Complication ◽

Dose Methotrexate

Background: High-dose methotrexate (HDMTX) is likely to cause a number of side effects and manifest itself as hepatotoxicity, nephrotoxicity, mucositis, and neurotoxicity. A several studies demonstrated the efficacy of extracorporeal detoxification methods such as plasma exchange, hemodialysis (HD), HD filtration, and hemoperfusion for the treatment of MTX delayed clearance. However, none of the existing methods as effective as expected and limited for general implementation due to a procedure-related complication. Case Report: Here, we report a successful implementation of HA-230 hemoadsorption procedure to remove cumulated MTX from the body and reduce its toxicity in a child with ALL after high-dose chemotherapy. Results and Conclusion: Based on our results, single-hemoadsorption procedure with the HA-230 adsorber in case of delayed methotrexate clearance was safe and well-tolerated in a pediatric patient with ALL and would significantly improve the patient’s condition. Further studies need to demonstrate its safety and efficacy in a large number of pediatric patients.

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Severe Oral Mucositis in a Patient With Acute Lymphocytic Leukemia: Case Report

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2013.12.208 ◽

2014 ◽

Vol 117 (2) ◽

pp. e189

Author(s):

JEFFERSON FREIRE CARDOSO ◽

REBEKA THIARA NASCIMENTO DOS SANTOS ◽

CÉLIA MARIA BOLOGNESE FERREIRA ◽

JECONIAS CAMARA ◽

TATIANA NAYARA LIBORIO

Keyword(s):

Case Report ◽

Oral Mucositis ◽

Acute Lymphocytic Leukemia ◽

Lymphocytic Leukemia ◽

Severe Oral Mucositis

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Energy Metabolism of Human Leukemic Lymphocytes and Granulocytes

Blood ◽

10.1182/blood.v30.2.151.151 ◽

1967 ◽

Vol 30 (2) ◽

pp. 151-167 ◽

Cited By ~ 20

Author(s):

JOHN LASZLO ◽

Clarence Ellis

Keyword(s):

Energy Metabolism ◽

Chronic Lymphocytic Leukemia ◽

Glucose Concentration ◽

Acute Lymphocytic Leukemia ◽

Aerobic Glycolysis ◽

High Energy ◽

Lymphocytic Leukemia ◽

Anaerobic Conditions ◽

High Energy Phosphate

Abstract 1. Leukocytes taken from patients having acute lymphocytic leukemia and chronic lymphocytic leukemia are characterized by high respiratory rates and low to absent aerobic glycolysis. Leukemic granulocytes have low respiratory rates and high aerobic glycolysis. 2. Lymphocytes and granulocytes have the capacity for high glycolytic rates under anaerobic conditions. 3. Lymphocyte respiration is independent of glucose concentration in contrast to granulocyte respiration. 4. High energy phosphate levels of lymphocytes and granulocytes are unchanged if these cells are incubated aerobically, either with or without glucose, or anaerobically in the presence of glucose. 5. Aerobic glycolysis can be induced in lymphocytes by the addition of foreign plasma. Foreign plasma may also alter granulocyte metabolism.

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