Efficacy of Intravenous Paracetamol and Ibuprofen on Postoperative Pain and Morphine Consumption in Lumbar Disc Surgery: Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

2021 ◽  
Author(s):  
Sedat Akbas ◽  
Ahmet Selim Ozkan ◽  
Mehmet Akif Durak ◽  
Saim Yologlu
Keyword(s):  
Clinical Trial ◽  
Postoperative Pain ◽  
Lumbar Disc ◽  
Morphine Consumption ◽  
Lumbar Disc Surgery ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Disc Surgery ◽  
Intravenous Paracetamol

Efficacy of intravenous paracetamol, metamizol and lornoxicam on postoperative pain and morphine consumption after lumbar disc surgery

2010 ◽  
Vol 27 (5) ◽  
pp. 428-432 ◽  
Author(s):  
Ozlem Korkmaz Dilmen ◽  
Yusuf Tunali ◽  
Ozlem S Cakmakkaya ◽  
Ercument Yentur ◽  
Ayse C Tutuncu ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Lumbar Disc ◽  
Morphine Consumption ◽  
Lumbar Disc Surgery ◽  
Disc Surgery ◽  
Intravenous Paracetamol

Intrathecal steroids to reduce pain after lumbar disc surgery: a double-blind, placebo-controlled prospective study

Pain ◽  
1995 ◽  
Vol 62 (3) ◽  
pp. 357-361 ◽  
Author(s):  
Johann J. Langmayr ◽  
Alois A. Obwegeser ◽  
Andreas B. Schwarz ◽  
Ilse Laimer ◽  
Hanno Ulmer ◽  
...  
Keyword(s):  
Prospective Study ◽  
Lumbar Disc ◽  
Lumbar Disc Surgery ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Disc Surgery

Effect of Celecoxib and Dexamethasone on Postoperative Pain after Lumbar Disc Surgery

Neurosurgery ◽  
2003 ◽  
Vol 53 (2) ◽  
pp. 331-337 ◽  
Author(s):  
Matthias Karst ◽  
Tanja Kegel ◽  
Anne Lukas ◽  
Wolf Lüdemann ◽  
Samii Hussein ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Lumbar Disc ◽  
Lumbar Disc Surgery ◽  
Double Blind Study ◽  
Double Blind ◽  
Wound Area ◽  
Pain Scores ◽  
Disc Surgery ◽  
Pain At Rest ◽  
To Receive

Abstract OBJECTIVE This study was designed to assess the efficacy of perioperative administration of celecoxib (Celebrex; Pharmacia GmbH, Erlangen, Germany) in reducing pain and opioid requirements after single-level lumbar microdiscectomy. METHODS We studied 34 patients (mean age, 44.26 yr; standard deviation [SD], 13.09 yr) allocated randomly to receive celecoxib 200 mg twice a day for 72 hours starting on the evening before surgery or placebo capsules in a double-blind study. Fourteen patients received 20 to 80 mg dexamethasone intravenously during surgery (mean, 40 mg; SD, 19.22 mg) because of visible signs of compression of the affected nerve root. After lumbar disc surgery, patients were monitored for visual analog scores for pain at rest and on movement, patient-controlled analgesia (PCA) piritramide requirements, and von Frey thresholds in the wound area. RESULTS Pain scores decreased and wound von Frey thresholds increased continuously until discharge, with no intergroup differences. Mean 24-hour PCA piritramide requirements were 22.63 mg (SD, 23.72 mg) and 26.14 mg (SD, 22.57 mg) in the celecoxib and placebo groups, respectively (P = not significant). However, patients with intraoperative dexamethasone (n = 14) required only 10.29 mg (SD, 8.55 mg) 24-hour PCA piritramide, in contrast to the 34.25 mg (SD, 24.69 mg) needed in those who did not receive intraoperative dexamethasone (P = 0.001). In addition, 24 hours after the operation, pain scores on movement were significantly lower in the dexamethasone subgroup (P = 0.003). CONCLUSION Celecoxib has no effect on postoperative pain scores and PCA piritramide requirements. The intraoperative use of 20 to 80 mg dexamethasone is able to significantly decrease postoperative piritramide consumption and pain scores on the first day after surgery.

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